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Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy.
Edridge, Arthur W D; Deijs, Martin; Namazzi, Ruth; Cristella, Cosimo; Jebbink, Maarten F; Maurer, Irma; Kootstra, Neeltje A; Buluma, Linda R; van Woensel, Job B M; de Jong, Menno D; Idro, Richard; Boele van Hensbroek, Michael; van der Hoek, Lia.
Clin Infect Dis ; 68(1): 139-142, 2019 01 01.
Article in English | MEDLINE | ID: mdl-29893821

ABSTRACT

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.


Subject(s)
Bunyaviridae Infections/diagnosis , Bunyaviridae Infections/virology , Cerebrospinal Fluid/virology , Encephalitis, Viral/diagnosis , Encephalitis, Viral/virology , Orthobunyavirus/classification , Orthobunyavirus/isolation & purification , Child, Preschool , Female , Genotype , Humans , Metagenomics , Orthobunyavirus/genetics , Uganda
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