[The enzymes of blood plasma and hepatic tissue in children are dependent on stage of transition to chronic state of viral hepatitis].

The detection of activity of enzymes in hepatic tissue and whole blood in children aged 12-16 years with chronic viral hepatitis was carried out. The results of study demonstrated that the level of metabolic parameters during the third stage of transition of disease to the chronic state as compared with the second stage testifies the presence of deeper functional affection of hepatic cells and more expressed metabolism disorders. The character of ratio of levels of activity of enzymes in liver and blood of children under the second and third stages of transition of disease to chronic state was analyzed. It is affirmed that the blood enzymatic indicators reflect specificity and direction of alterations of metabolic processes in hepatic cells under chronic hepatitis C. This process can be used as a basis for development of new diagnostic approaches to this form of pathology.

[The activity of enzymes in lymphocytes of children and adults with chronic viral hepatitis B and C].

It is established that in patients with chronic viral hepatitis B and C the intensity of reaction is increased in lymphocytes of children as compared with adults. The study also established the limitation of turning out of substrates for macromolecular synthesis and the decrease of activity of reactions of tricarbonic acid cycle at the expense of decreasing of substrates flow from amino-acid metabolism included. Under chronic hepatitis C, in lymphocytes the levels of activity of enzymes involved in functioning of main metabolic paths and glutathione system of antioxidant defense of are decreased in children as compared with adults.