[Nephropathy-related disorders of physical and sexual development in girls: experience with successful stimulation by zinc, parlodel and norcolut]. / Sviazannoe s nefropatiiami narushenie fizicheskogo i polovogo razvitiia u devushek: opyt uspeshnoi stimuliatsii tsinkom, parlodelom i norkolutom.

The paper reports 3 cases of physical and sexual retardation in girls aged 14-22 with nephropathy: 1 girl had uremia in a conservative stage, 1 patient was put on a chronic hemodialysis for terminal uremia, 1 girl received a renal transplant. In response to combined treatment (zinc sulfate+parlodel) in the former two patients and norcolute therapy in the latter one body mass and growth increased in all the 3. The discussion is concerned with mechanisms of developmental defects in nephropathies, comparative efficacy of the drugs used and social rehabilitation of nephropathy girls with small height and sexual infantilism.

[Pathospermia in patients with glomerulonephritis and rheumatoid arthritis treated by immunodepressants: the possibilities of its correction with zinc and parlodel]. / Patospermiia u bol'nykh glomerulonefritom i revmatoidnym artritom, lechivshikhsia immunodepressantami: vozmozhnosti korrektsii tsinkom i parlodelom.

Two groups of patients aged 16.5-31 years with pathospermia given immunodepressants (IDS) for glomerulonephritis (group I) or rheumatoid arthritis (group II) before and/or at the moment of examination were examined. Five out of 6 patients of group I and all the patients of group II showed azoospermia. As a result of the treatment with zinc (30-90 mg of elementary zinc a day) and parlodel (2.5 mg/day) for 2-23 months, spermatogenesis improved or returned to normal in 2 patients of group I and in 2 patients of group II. It should be mentioned that out of 8 patients who turned out refractory to the treatment, 7 received glucocorticoids and cytostatics (CT) whereas among those who responded to the treatment, only 2 patients out of 4 were given CT. The reported data on the gonadotoxic dose of CT are discussed. The conclusion is made about the necessity of carrying out active treatment policy for pathospermia in patients who received IDS.

[Zinc and parlodel: the treatment potentials for retardation of growth and sexual development in nephropathies in adolescents]. / Tsink i parlodel: vozmozhnosti lecheniia zaderzhki rosta i polovogo razvitiia pri nefropatiiakh u podrostkov.

Ten adolescents aged 10-18 years with physical and/or sexual development retardation associated with nephropathy were examined. Eight patients were treated with immunodepressants before and/or at the moment of examination. The difference between the age indicated in the patient's passport and bone age ranged within 0 to 3 years. On spermogram examination 3 of 4 patients manifested pathospermia. The serum prolactin level and the level of gonadotropins appeared normal but the testosterone content and plasma zinc level were lowered. As a result of the treatment with parlodel and/or zinc acetate for 1.5 to 23 months, 9 of 10 patients demonstrated the rise of the height and body weight and developed secondary sexual signs. In 3 of 4 patients examined for that parameter, the spermograms improved. In the whole group, the concentration of blood prolactin decreased, that of testosterone and zinc rose, whereas the content of gonadotropins remained unchanged.

[Zinc in the treatment of hypogonadism in patients with renal pathology]. / Tsink v lechenii gipogonadizma u bol'nykh s patologiei pochek.

The relationship of the symptoms of hypogonadism (HG) with the serum level (SL) of zinc was investigated in 31 uremic male patients: 16 on hemodialysis (I group), 10 on a low-protein diet (II group), and 5 kidney graft recipients (III group). A conclusion has been made that in renal pathology a zinc SL does not always reflect the content of zinc in the body however zinc acetate therapy is effective in the treatment of HG patients as well as in the treatment of retarded physical and sexual development in adolescents with nephropathies.

[Characteristics of the functioning of the human hypophyseal-gonadal system during 1-time sleep deprivation]. / Osobennosti funktsionirovaniia gipofizarno-gonadnoi sistemy cheloveka v usloviiakh odnokratnoi deprivatsii sna.

The authors studied indices of the activity of the hypophyseogonadal system under the conditions of single sleep deprivation of 24-36 h duration and in the period of recovery. Eleven healthy men aged 21 to 26 were recruited in the study. Two series of investigations were performed: I--the examinees were studied before, after 24 h sleep deprivation and after the first recovery night; II--the scheme of investigation was identical but it included electroauriculopuncture 5-6 h after the start of sleep deprivation. The 24 h sleep deprivation was accompanied by an increase in ACTH and LH secretion, a decrease in the levels of STH, prolactin, total androgens and progesterone in the examinees' blood. On the whole, electroauriculopuncture optimized the activity of the hypophyseogonadal system expressed in lesser changes in the secretion of the above hormones in response to sleep deprivation.

Parlodel treatment of uremic hypogonadism in men.

Parlodel, 2.5 mg daily, was given during 1-3 months to 14 uremic hypogonadal patients (placebo controlled in 6). Except for a decrease in serum prolactin levels on Parlodel (p less than 0.01), no significant changes in hormonal values (gonadotropins and testosterone) were observed either on Parlodel or on placebo. Parlodel treatment improved the potency of 10 patients, eliminated gynecomastia in 2 and normalized spermatogenesis in 6; the best results were obtained in patients on low-protein diet. On placebo, potency improved only in 1 patient; no improvement in spermatogenesis was registered. Thus, Parlodel can improve sexual function and spermatogenesis in hypogonadal uremic males.

[Participation of adrenal hormones in the genesis of arterial hypertension of hypothalamic origin]. / Ob uchastii gormonov nadpochechnikov v geneze arterial'noi gipertenzii gipotalamicheskogo proiskhozhdeniia

Continuous many-hour stimulation of the hypothalamic negative emotiogenic centres (ventromedial nuclei) evoked a stable arterial hypertension with a peculiar phasic dynamics of the adrenal secretory activity in waking immobilized rabbits. Bilateral extirpation of the adrenal glands decreased the initial level of the average arterial pressure, inhibiting development of stable arterial hypertension. Many-hour stimulation of the mentioned structures also produced stable arterial hypertension in adrenalectomized rabbits if preceded by the administration of hydrocortisone together with adrenaline. Against the background of separate administration of hydrocortisone and adrenaline to adrenalectomized rabbits, many-hour stimulation of the ventromedial hypothalamus evoked a short-term rise in the arterial pressure. A conclusion was drawn that activation of hormones of the adrenal cortical and medullary layers played an important part in the formation of stable arterial hypertension in rabbits under continuous many-hour stimulation of the hypothalamic negative emotiogenic centres.