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1.
J Biomater Appl ; 30(6): 677-85, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26024896

ABSTRACT

Graphene is another allotrope of carbon with two-dimensional monolayer honeycomb. Owing to its special characteristics including electrical, physical and optical properties, graphene is known as a more suitable candidate compared to other materials to be used in the sensor application. It is possible, moreover, to use biosensor by using electrolyte-gated field effect transistor based on graphene (GFET) to identify the alterations in charged lipid membrane properties. The current article aims to show how thickness and charges of a membrane electric can result in a monolayer graphene-based GFET while the emphasis is on the conductance variation. It is proposed that the thickness and electric charge of the lipid bilayer (LLP and QLP) are functions of carrier density, and to find the equation relating these suitable control parameters are introduced. Artificial neural network algorithm as well as support vector regression has also been incorporated to obtain other models for conductance characteristic. The results comparison between analytical models, artificial neural network and support vector regression with the experimental data extracted from previous work show an acceptable agreement.


Subject(s)
Biosensing Techniques/instrumentation , Conductometry/instrumentation , Graphite/chemistry , Lipid Bilayers/chemistry , Transistors, Electronic , Electric Conductivity , Equipment Design , Equipment Failure Analysis , Lipid Bilayers/analysis , Membrane Potentials , Reproducibility of Results , Sensitivity and Specificity
2.
IET Nanobiotechnol ; 9(5): 273-9, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26435280

ABSTRACT

Graphene is an allotrope of carbon with two-dimensional (2D) monolayer honeycombs. A larger detection area and higher sensitivity can be provided by graphene-based nanosenor because of its 2D structure. In addition, owing to its special characteristics, including electrical, optical and physical properties, graphene is known as a more suitable candidate compared to other materials used in the sensor application. A novel model employing a field-effect transistor structure using graphene is proposed and the current-voltage (I-V) characteristics of graphene are employed to model the sensing mechanism. This biosensor can detect Escherichia coli (E. coli) bacteria, providing high levels of sensitivity. It is observed that the graphene device experiences a drastic increase in conductance when exposed to E. coli bacteria at 0-10(5) cfu/ml concentration. The simple, fast response and high sensitivity of this nanoelectronic biosensor make it a suitable device in screening and functional studies of antibacterial drugs and an ideal high-throughput platform which can detect any pathogenic bacteria. Artificial neural network and support vector regression algorithms have also been used to provide other models for the I-V characteristic. A satisfactory agreement has been presented by comparison between the proposed models with the experimental data.


Subject(s)
Biotechnology/instrumentation , Electrochemical Techniques/instrumentation , Escherichia coli/isolation & purification , Graphite/chemistry , Biotechnology/methods , Electrochemical Techniques/methods
3.
Nanoscale Res Lett ; 9(1): 402, 2014.
Article in English | MEDLINE | ID: mdl-25177219

ABSTRACT

Carbonaceous materials have recently received attention in electronic applications and measurement systems. In this work, we demonstrate the electrical behavior of carbon films fabricated by methane arc discharge decomposition technique. The current-voltage (I-V) characteristics of carbon films are investigated in the presence and absence of gas. The experiment reveals that the current passing through the carbon films increases when the concentration of CO2 gas is increased from 200 to 800 ppm. This phenomenon which is a result of conductance changes can be employed in sensing applications such as gas sensors.

4.
Sensors (Basel) ; 14(3): 5502-15, 2014 Mar 20.
Article in English | MEDLINE | ID: mdl-24658617

ABSTRACT

Carbon Nanotubes (CNTs) are generally nano-scale tubes comprising a network of carbon atoms in a cylindrical setting that compared with silicon counterparts present outstanding characteristics such as high mechanical strength, high sensing capability and large surface-to-volume ratio. These characteristics, in addition to the fact that CNTs experience changes in their electrical conductance when exposed to different gases, make them appropriate candidates for use in sensing/measuring applications such as gas detection devices. In this research, a model for a Field Effect Transistor (FET)-based structure has been developed as a platform for a gas detection sensor in which the CNT conductance change resulting from the chemical reaction between NH3 and CNT has been employed to model the sensing mechanism with proposed sensing parameters. The research implements the same FET-based structure as in the work of Peng et al. on nanotube-based NH3 gas detection. With respect to this conductance change, the I-V characteristic of the CNT is investigated. Finally, a comparative study shows satisfactory agreement between the proposed model and the experimental data from the mentioned research.


Subject(s)
Gases/analysis , Nanotechnology/instrumentation , Nanotechnology/methods , Nanotubes, Carbon/chemistry , Adsorption , Ammonia/analysis , Temperature , Transistors, Electronic
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