ABSTRACT
Tissues from four cases of Kaposi's sarcoma developing in renal transplant recipients were studied by light and electron microscopic examination and by immunoperoxidase staining for Factor-VIII-related antigen. Ultrastructurally, the tumors in all four cases contained a variable mixture of cells, including endothelial cells, pericytes, fibroblasts, and myofibroblasts. These findings support the origin of Kaposi's sarcoma from primitive vasoformative mesenchyme. Immunoperoxidase staining for Factor-VIII-related antigen was limited to endothelial cells. In one case intracytoplasmic virus-like tubular complexes were seen. The significance of this finding is briefly discussed.
Subject(s)
Extremities , Factor VIII/analysis , Immunoenzyme Techniques , Kidney Transplantation , Sarcoma, Kaposi/complications , Adult , Antigens/analysis , Biopsy , Female , Histocytochemistry , Humans , Male , Middle Aged , Sarcoma, Kaposi/ultrastructure , Schwann Cells/ultrastructureABSTRACT
We have concentrated plasma coagulation factors by a process of ultrafiltration (UF) using a hollow fiber artificial kidney with applied negative pressure. The coagulation factors were concentrated by between 2.4 and 3.2 times, resulting in yields of 82-100%. There was no evidence of activation of coagulation factors as shown by approximately equal increases in the concentrations of all three moieties of factor VIII following ultrafiltration, and by the fact that plasma recalcification times post-UF were not increased. It is suggested that the concentrated plasma product from UF may be useful in replacement therapy.
Subject(s)
Blood Coagulation Factors/isolation & purification , Kidneys, Artificial , Ultrafiltration/methods , Blood Coagulation , Blood Coagulation Factors/therapeutic use , HumansABSTRACT
A patient is described who developed the lesion of Kaposi's sarcoma 4 months after receiving a cadaveric renal transplant. Immunosuppression had been achieved using cyclosporin A and prednisolone. The lesions spread from the hands to other areas, but later regressed when the dose of cyclosporin A was reduced to 100 mg daily. The patient remains well with no evidence of rejection 15 months later.
Subject(s)
Immunosuppression Therapy/adverse effects , Kidney Transplantation , Sarcoma, Kaposi/etiology , Skin Neoplasms/etiology , Humans , Male , Middle AgedABSTRACT
An unusual case of nephrotic syndrome secondary to preeclamptic nephropathy is documented. The preeclampsia was associated with a transitional mole with coexistent fetus. A review of the literature revealed only one similar case reported previously. Immuno-pathologic examination of the renal biopsy revealed abundant IgM and fibrinogen within the glomeruli; electron microscopy showed numerous subendothelial and occasional intramesangial deposits of electron-dense material. The significance of these findings with regard to the pathogenesis of preeclamptic nephropathy is briefly discussed.
Subject(s)
Hydatidiform Mole/complications , Nephrotic Syndrome/etiology , Pre-Eclampsia/complications , Uterine Neoplasms/complications , Adult , Female , Histocytochemistry , Humans , Immunoglobulin M , Kidney Glomerulus/immunology , Kidney Glomerulus/pathology , Kidney Glomerulus/ultrastructure , Microscopy, Electron , Nephrotic Syndrome/pathology , Placenta/pathology , PregnancyABSTRACT
For the first time, to our knowledge, a patient with a functioning pheochromocytoma was subjected to gel foam embolization for physiologic destruction of the tumor. The operation, 24 hours later, provided an uneventful anatomic removal of the infarcted tumor. Observation was considered as a possible alternative to surgical excision. Experience gained may allow testing of the validity of a nonoperative approach in selected cases.
