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J Med Genet ; 22(2): 147-9, 1985 Apr.
Article in English | MEDLINE | ID: mdl-3989833

ABSTRACT

A case of holoprosencephaly is reported in which the mother was prescribed high doses of oestroprogestins during the first 5 months of the pregnancy. Investigation of the family failed to reveal any sign of physical abnormality. A normal karyotype was detected in the proband. The authors suggest that this case may shed some light on the normal and abnormal way in which embryonic fields develop.


Subject(s)
Abnormalities, Drug-Induced/etiology , Allylestrenol/adverse effects , Brain/abnormalities , Dydrogesterone/adverse effects , Estrenes/adverse effects , Abortion, Spontaneous/prevention & control , Adult , Allylestrenol/therapeutic use , Dydrogesterone/therapeutic use , Female , Humans , Infant, Newborn , Male , Pregnancy
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