[Optimizing the composition of the medium for the biosynthesis of antibiotic, proteases and pigments by the mycophilic fungus Hypomyces rosellus using a mathematical experimental design method]. / Optimizatsiia sostava sredy dlia biosinteza antibiotika, proteaz i pigmentov mikofil'nym gribom Hypomyces rosellus s pomoshch'iu metoda matematicheskogo planirovaniia ékpserimenta.

Regulation of protease and pigment production in Hypomyces rosellus by the medium components was easier than that of antibiotic production. Medium was developed. The activity of exoproteases and pigment with the use of this medium increased up to 385-800 PU/ml and 0.68-0.83 arbitrary units, respectively. The level of the antibiotic biosynthesis was insignificant.

[Effect of various carbon and nitrogen sources on the biosynthesis of ristomycin, protease and pigments by a culture of Nocardia fructiferi var. ristomycini]. / Vliianie razlichnykh istochnikov ugleroda i azota na biosintez ristomitsina, proteazy i pigmentov kul'turoi Nocardia fructiferi var. ristomycini.

The effect of various sources of carbon and nitrogen on the biosynthesis of ristomycin, protease and pigments by Nocardia fructiferi was studied. It was shown that the carbon sources had the most significant effect on the biosynthesis of the antibiotic. The maximum biosynthetic activity of the Nocardia was observed in the medium containing 1-2 per cent of soybean meal and 2 per cent of glycerol. Under such conditions all the three biologically active substances formed. The contents of ristomycin, protease and pigments amounted to 562-649 microgram/ml, 26-30 PU/ml and 0.45-0.63 conditional units, respectively.