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Probl Tuberk ; (4): 32-6, 2002.
Article in Russian | MEDLINE | ID: mdl-12125250

ABSTRACT

The efficiency of the use of the natural drug Galstena (Richard Bittner GmbH) was experimentally and clinically studied on a model of damage induced by toxic doses of tuberculostatics (rifampicin, isoniazid, pyrazinamide) in laboratory rats and in patients with different forms of pulmonary tuberculosis and with hepatitis caused by specific antituberculous drug therapy, who were treated at the Clinic of Phthiziology. Galstena was found to have marked hepatoprotective properties and to be able to prevent renal and pancreatic disorders. The drug also showed an antioxidative activity. The use of Galstena in patients with pulmonary tuberculosis substantially reduced the magnitude of clinical and laboratory signs of drug-induced hepatic damage.


Subject(s)
Antitubercular Agents/adverse effects , Chemical and Drug Induced Liver Injury/drug therapy , Chemical and Drug Induced Liver Injury/etiology , Phytotherapy , Plant Extracts/therapeutic use , Protective Agents/therapeutic use , Adult , Animals , Chemical and Drug Induced Liver Injury/prevention & control , Drug Administration Routes , Female , Humans , Male , Middle Aged , Rats , Tuberculosis, Pulmonary/drug therapy
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