ABSTRACT
El desarrollo de las estructuras faciales está a cargo de células derivadas de la cresta neural, alteraciones en la migración o proliferación celular pueden desencadenar malformaciones nasales. Los defectos nasales son tan antiguos como la humanidad, sin embargo, descripciones anatómicas detalladas de estas malformaciones nasales congénitas y sus reconstrucciones son escasas. La hipoplasia nasal puede definirse como un trastorno en el desarrollo de los huesos y cartílagos nasales, y debe ser diferenciada de la arrinia, la cual consiste en la ausencia de nariz y fosas nasales. Los tejidos autologos son los injertos preferidos para la reconstrucción nasal. El tabique nasal, el cartílago auricular, la calota y el cartílago costal son los más usados; pero, estos recursos son limitados, impredecibles y causan algún grado de morbilidad en el sitio donante. Se presenta el primer caso de ausencia de huesos nasales, septum nasal y cartílagos laterales superiores con cartílagos alares intactos. Adicionalmente se presentan los detalles de la reconstrucción usando aloplasticos de alta densidad (polietileno, MEDPOR)...
Neural crest cells are responsible for the development of facial structures, migration failure, decreased proliferation or increased apoptosis may cause nasal anomalies. Nasal defects have existed as long as man; but, detailed anatomic descriptions of congenital nasal defects are rare, the ones including surgical reconstruction are even fewer. Nasal hypoplasia could be defined as nasal bone and cartilage maldevelopment and must be differentiated from congenital arhinia consisting of an absence of nasal structures and passages. Autogenous tissues have been the gold standard graft material for nasal reconstruction; septum, ear, rib and calvarium are preferred. Here, we report the first case of a non-syndromic absence of nasal bones, upper lateral cartilages and septum, with intact lower lateral cartilages and its reconstruction using high-density polyethylene (Medpor)...
Subject(s)
Humans , Nose Diseases , Nose/physiologySubject(s)
Endoscopy , Glioma/congenital , Glioma/surgery , Nasal Cavity , Nose Neoplasms/congenital , Nose Neoplasms/surgery , Endoscopy/methods , Glioma/diagnostic imaging , Glioma/embryology , Humans , Infant, Newborn , Male , Nasal Cavity/embryology , Nose Neoplasms/diagnostic imaging , Nose Neoplasms/embryology , Tomography, X-Ray ComputedSubject(s)
Erythrocytes/metabolism , Sodium/blood , Adolescent , Adult , Age Factors , Aged , Female , Humans , Male , Middle Aged , Sex FactorsABSTRACT
A significant mean increase of 18% in erythrocyte sodium pump activity (p less than 0.01, t test) was observed during lithium treatment, as compared with the activity before lithium treatment was started, in a group of 20 patients who were treated with lithium therapy for a variety of psychiatric conditions. The mean level of erythrocyte membrane ouabain-sensitive ATPase activity in a group of 35 subjects who were receiving lithium therapy was significantly higher than that of a different group of 38 subjects who were not receiving lithium therapy (p less than 0.005, t test). These observations may offer a biochemical mode of action for lithium in the treatment of bipolar affective disorder, since a deficiency of sodium pump activity has been shown to be associated with that disorder.
