Subject(s)
Aspirin/adverse effects , Verapamil/adverse effects , Aged , Aged, 80 and over , Drug Interactions , Humans , MaleABSTRACT
BRL 42715 is a new penem which inhibits a wide range of plasmid as well as chromosomally mediated bacterial beta-lactamases. We used a total of 902 recent clinical isolates, consisting of 455 Enterobacteriaceae, 247 staphylococci and 200 other gram-negative bacteria to evaluate its ability for potentiation of amoxycillin. MICs for all the 104 strains of methicillin-susceptible Staphylococcus aureus were reduced from 8-greater than 32.0 to less than or equal to 0.06 micrograms/ml in the presence of 1-5 micrograms/ml of this penem. It was also highly effective in inhibiting the beta-lactamase of a wide variety of gram-negative bacteria, thereby bringing their MIC values for amoxycillin from a 'resistant' range (greater than 32.0 micrograms/ml) to a 'susceptible' range (less than or equal to 8.0 micrograms/ml). Commonly resistant bacteria like Klebsiella, Enterobacter, Citrobacter, Morganella, Serratia, Acinetobacter and Aeromonas were rendered susceptible to amoxycillin in the presence of 1.0-5.0 micrograms/ml of BRL 42715.
Subject(s)
Amoxicillin/pharmacology , Anti-Bacterial Agents/pharmacology , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Lactams , beta-Lactamase Inhibitors , beta-Lactams , Drug Synergism , Drug Therapy, Combination/pharmacology , Enterobacteriaceae/drug effects , Humans , Microbial Sensitivity TestsABSTRACT
Leukocyte migration inhibition factor (LMIF) assays have been used as a measure of cell-mediated immune responses. Direct assays of this factor were determined in 30 patients with recurrent herpes simplex stromal keratitis during the quiescent stage of the disease and in 10 of these patients during the acute stage as well. The migration of leukocytes incubated in the presence of HSV antigens was compared to that without viral antigens for the migration index (MI). Only 1 out of 30 patients had a positive response during the quiescent stage, while among the 10 patients with the active disease, four had a positive response.
Subject(s)
Cell Migration Inhibition , Keratitis, Dendritic/immunology , Adolescent , Adult , Animals , Antigens, Viral/analysis , Child , Guinea Pigs , Humans , Immunity, Cellular , Leukocyte Migration-Inhibitory Factors/immunology , Middle Aged , Neutralization Tests , Recurrence , Simplexvirus/immunologyABSTRACT
The Social Security Administration 1972 Survey of Disabled and Nondisabled Adults showed that an estimated 15.6 million adults aged 20--64, or 15 percent of the total noninstitutionalized population of those ages, were disabled as a result of some chronic condition or impairment. Yet more than three times as many persons (51.8 million) reported that they suffered from one or more chronic health conditions. The diseases reported most frequently by the adult population of working age were cardiovascular and musculoskeletal disorders, each with prevalence rates of 200 persons per 1,000 population. The prevalence rate for neurological disorders was only 7 persons per 1,000; their disabling potential, however, was much greater than that for the diseases with the highest prevalence rates: 80 percent of those suffering from neurological disorders were also currently disabled. For almost every disease group, older persons were more likely to suffer from a chronic condition or impairment and more likely to be disabled as a result. Women were more likely than men to report a chronic disease or impairment and more likely to be severely disabled as a result. White persons were somehwat more likely than blacks and members of other races to report one or more chronic conditions but less likely to be disabled as a result and even less likely to be severely disabled. Among the nondisabled, less than one-tenth reported a condition caused by accident or injury but close to one-fourth of the disabled reported a disease or impairment of accidental origin.
