ABSTRACT
A trial of a newly developed experimental model of prostatic cancer showed its convenience in simulating clinical symptoms and response to treatment. The model is effective in the studies of anticancer drugs with various mechanisms of action with special emphasis on immunomodulators as a promising adjuvant modality.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Disease Models, Animal , Prostatic Neoplasms/drug therapy , Animals , Antineoplastic Agents/administration & dosage , Antineoplastic Agents, Hormonal/administration & dosage , Carcinogens , Dienestrol/administration & dosage , Dihydrotestosterone/administration & dosage , Dihydrotestosterone/analogs & derivatives , Drug Combinations , Drug Screening Assays, Antitumor , Estrogens, Non-Steroidal/administration & dosage , Flutamide/administration & dosage , Male , Methylcholanthrene , Neoplasm Transplantation , Nitrogen Mustard Compounds/administration & dosage , Prostatic Neoplasms/chemically induced , Rats , TestosteroneABSTRACT
Therapeutic efficacy of surfagon, an analog of LH-RH which was injected subcutaneously at a daily dose of 100 micrograms/kg for 30 days, was investigated in ACI male rats with induced prostatic adenoma. This drug was shown to be effective proceeding from a morphological study and measurement of the prostate. Measurement of blood testosterone levels by radioimmunoassay showed a decrease in this level in rats, treated with surfagon, i. e. a therapeutic effect of the drug in prostatic adenoma was accompanied by a decrease in the level of androgens.
Subject(s)
Gonadotropin-Releasing Hormone/analogs & derivatives , Hormones/therapeutic use , Prostatic Hyperplasia/drug therapy , Animals , Gonadotropin-Releasing Hormone/therapeutic use , Male , Prostatic Hyperplasia/blood , Prostatic Hyperplasia/pathology , Rats , Rats, Inbred ACI , Testosterone/bloodABSTRACT
The investigation of ovary tumours induced by different methods has revealed their highest frequency (75%) and shortest latent period (4 months) when the ovaries were transplanted into the spleen. The incidence of ovary tumours induced by carcinogens, androgen, subtotal castration and irradiation accounted for 14-28%. Histological picture of the ovary tumours (granulosa cell tumours, granulosa-thecoma, luteoma) was identical in all the experimental groups.
Subject(s)
Disease Models, Animal , Ovarian Neoplasms/etiology , 1,2-Dimethylhydrazine , Animals , Dimethylhydrazines , Female , Methods , Neoplasm Transplantation , Neoplasms, Radiation-Induced/etiology , Ovarian Neoplasms/pathology , Ovariectomy , Ovary/transplantation , Rats , Testosterone , Time Factors , Transplantation, AutologousABSTRACT
A single injection of partially hepatectomized rats with glucocorticoids results in the blocking of DNA synthesis as well as in the inhibition of the protooncogene Ha-ras-1 mRNA accumulation in proliferating rat liver cells. The kinetics of the both hormone-induced effects differ from those observed for tyrosine aminotransferase induction. The effect of glucocorticoids persists for at least 48 hours and does not depend on the time of the hormone injection.
Subject(s)
DNA/biosynthesis , Glucocorticoids/pharmacology , Liver/metabolism , Proto-Oncogenes , Animals , Cell Division , Hepatectomy , Liver/cytology , Liver/drug effects , Male , RNA, Messenger/biosynthesis , RatsABSTRACT
Development of the DMBA-induced breast cancer in rats resulted in an increase of the thyrotropin, somatotropin and prolactin concentrations in blood plasma. Thyroliberin (TRH) stimulation of the thyrotropin secretion was decreased. Basal levels of the corticotropin (ACTH) and lutropin (LH) as well as of the luliberin (LRH) stimulation of the LH secretion were not changed. Concentrations of estradiol, corticosterone and insulin enhanced, those of testosterone, progesterone and thyroxine lowered. Out of two calcitropic hormones, RTH and CT, the secretion of the latter increased.
Subject(s)
Hormones/blood , Mammary Neoplasms, Experimental/blood , 9,10-Dimethyl-1,2-benzanthracene , Adrenocorticotropic Hormone/blood , Animals , Estradiol/blood , Female , Growth Hormone/blood , Insulin/blood , Luteinizing Hormone/blood , Mammary Neoplasms, Experimental/chemically induced , Prolactin/blood , Rats , Rats, Inbred Strains , Thyrotropin/bloodABSTRACT
A comparative radioimmunologic study of changes in the ratio of calcitonin and parathyroid hormone secretion was carried out in healthy controls (young and older than 40 years), patients with benign tumors, inflammatory processes and malignancies of the stomach, kidney, breast, prostate and lung. A significant increase in the "calcitonin index" (ratio of molar concentrations of calcitonin and parathyroid hormone) was established in patients with cancer of the breast, prostate and skeletal metastases of lung cancer, irrespective of the presence of primary tumor. This index is irrelevant in cases of gastric and renal carcinoma and cannot be used a indication of skeletal dissemination because of the predominant level of parathyroid hormone secretion.
