Sepsis surveillance: an examination of parameter sensitivity and alert reliability.

OBJECTIVE: To examine performance of a sepsis surveillance system in a simulated environment where modifications to parameters and settings for identification of at-risk patients can be explored in-depth. MATERIALS AND METHODS: This was a multiple center observational cohort study. The study population comprised 14 917 adults hospitalized in 2016. An expert-driven rules algorithm was applied against 15.1 million data points to simulate a system with binary notification of sepsis events. Three system scenarios were examined: a scenario as derived from the second version of the Consensus Definitions for Sepsis and Septic Shock (SEP-2), the same scenario but without systolic blood pressure (SBP) decrease criteria (near SEP-2), and a conservative scenario with limited parameters. Patients identified by scenarios as being at-risk for sepsis were assessed for suspected infection. Multivariate binary logistic regression models estimated mortality risk among patients with suspected infection. RESULTS: First, the SEP-2-based scenario had a hyperactive, unreliable parameter SBP decrease >40 mm Hg from baseline. Second, the near SEP-2 scenario demonstrated adequate reliability and sensitivity. Third, the conservative scenario had modestly higher reliability, but sensitivity degraded quickly. Parameters differed in predicting mortality risk and represented a substitution effect between scenarios. DISCUSSION: Configuration of parameters and alert criteria have implications for patient identification and predicted outcomes. CONCLUSION: Performance of scenarios was associated with scenario design. A single hyperactive, unreliable parameter may negatively influence adoption of the system. A trade-off between modest improvements in alert reliability corresponded to a steep decline in condition sensitivity in scenarios explored.

Reliability and validity of a motion-based reaction time assessment using a mobile device.

Information processing speed is often altered following a concussion. Few portable assessments exist to evaluate simple reaction time (SRT) in hospitals and clinics. We evaluated the use of a SRT application for mobile device measurement. 27 healthy adults (age = 30.7 ± 11.5 years) completed SRT tests using a mobile device with Sway, an application for SRT testing. Participants completed computerized SRT tests using the Computerized Test of Information Processing (CTIP). Test-retest reliability was assessed using intraclass correlation coefficients (ICC) between Sway trials. Pearson correlations and Bland-Altman analyses were used to assess criterion validity between Sway and CTIP means. ICC comparisons between Sway tests were all statistically significant. ICCs ranged from 0.84-0.90, with p-values <.001. A one-way analysis of variance (ANOVA) revealed no significant differences between trials (F3,104 = 1.35, p = .26. Pearson correlation between Sway and CTIP outcomes yielded a significant correlation (r = 0.59, p = .001). The mean difference between measurement methods was 43.7 ms, with limits of agreement between -140.8-53.4 ms. High ICC indicates Sway is a reliable method to assess SRT. A strong correlation and clinically acceptable agreement between Sway and the computer-based test indicates that Sway is suited for rapid administration of SRT testing in healthy individuals. Future research using Sway to assess altered information processing in a population of individuals after concussion is warranted.

Underreporting of Concussions and Concussion-Like Symptoms in Female High School Athletes.

Underreporting of concussions and concussion-like symptoms in athletes continues to be a serious medical concern and research focus. Despite mounting worry, little evidence exists examining incidence of underreporting and documenting characteristics of head injury in female athletes participating in high school sports. This study examined the self-reporting behaviors of female high school athletes. Seventy-seven athletes participated, representing 14 high school sports. Nearly half of the athletes (31 participants) reported a suspected concussion, with 10 of the 31 athletes refraining from reporting symptoms to training staff after injury. Only 66% reported receiving concussion education. Concussion education appeared to have no relationship with diagnosed concussion rates in athletes, removing athletes from play, or follow-up medical care after injury. In conclusion, female high school athletes underreport signs and symptoms of concussions. Concussion education should occur at higher rates among female athletes to influence reporting behaviors.