Adding Cognitive Remediation to Employment Support Services: A Randomized Controlled Trial.

OBJECTIVE: Individual placement and support (IPS) is an evidence-based strategy that helps individuals with mental illness obtain and maintain competitive employment. Despite the approach's overall success, almost half of IPS clients do not find work. Impairment in cognitive abilities may hamper employment and limit the benefits from rehabilitation services such as IPS. This randomized controlled trial aimed to assess the effects of adding cognitive remediation therapy (CRT) for IPS clients who had difficulties finding employment. METHODS: At 14 mental health centers in Canada, 97 clients who had not found work after 3 months of receiving IPS services were recruited. Consenting clients were randomly assigned to either continue IPS alone or receive CRT added to IPS. The CRT used the Thinking Skills for Work protocol, a 12-week program that included computerized cognitive exercises along with coping strategies for managing cognitive challenges. RESULTS: Participants completed on average 10 of 12 individual training sessions in coping strategies and 12 of 24 computerized training sessions. The addition of CRT to IPS resulted in significantly more participants working at the 3-month (odds ratio [OR]=2.83, 95% confidence interval [CI]=1.22-6.60) and 9-month follow-ups (OR=2.91, 95% CI=1.27-6.65). Participants who received CRT worked more hours and earned more in wages than those receiving IPS alone over the 9-month follow-up period. Both groups showed significantly improved cognitive outcomes at the 3-month follow-up, with no time × group interaction. CONCLUSIONS: Cognitive remediation, especially skills training in coping and compensatory strategies, improves employment outcomes among individuals who do not show an early benefit of using IPS services.

Facial emotion memory in schizophrenia: From encoding to maintenance-related EEG.

OBJECTIVE: Persons with schizophrenia exhibit deficits recognizing facial emotions, which may impact social functioning. Whether these deficits reflect aberrant sensory processing, an inability to maintain information in memory, or dysfunctional integration of these two functions remains unclear. METHODS: A facial emotion memory paradigm was administered to 38 schizophrenia patients (SZ) and 42 healthy controls (HC). P100, N170 and N250 ERP amplitudes were measured to assess sensory processing. Evoked theta power during the delay interval was quantified to assess memory maintenance. RESULTS: The N170 ERP was larger to negative compared to neutral facial expressions in both groups, while SZ exhibited increased evoked theta power during the delay interval. Increased theta power was associated with worse behavioral performance in response to sad and fearful expressions for HC, but this relationship was only found in response to fearful expressions for SZ. Finally, only HC showed consistent correlations between N170 amplitude and theta power during the delay interval. CONCLUSIONS: Integration between measures of sensory processing and memory functioning may be affected in SZ. SIGNIFICANCE: These findings may indicate that the oscillatory networks subserving emotion processing and sustained attention are intertwined, and comprise part of the social brain network that is affected in schizophrenia.

The role of encoding and attention in facial emotion memory: an EEG investigation.

Facial expressions are encoded via sensory mechanisms, but meaning extraction and salience of these expressions involve cognitive functions. We investigated the time course of sensory encoding and subsequent maintenance in memory via EEG. Twenty-nine healthy participants completed a facial emotion delayed match-to-sample task. P100, N170 and N250 ERPs were measured in response to the first stimulus, and evoked theta power (4-7Hz) was measured during the delay interval. Negative facial expressions produced larger N170 amplitudes and greater theta power early in the delay. N170 amplitude correlated with theta power, however larger N170 amplitude coupled with greater theta power only predicted behavioural performance for one emotion condition (very happy) out of six tested (see Supplemental Data). These findings indicate that the N170 ERP may be sensitive to emotional facial expressions when task demands require encoding and retention of this information. Furthermore, sustained theta activity may represent continued attentional processing that supports short-term memory, especially of negative facial stimuli. Further study is needed to investigate the potential influence of these measures, and their interaction, on behavioural performance.

Cognitive-behavioral therapy for medication-resistant psychosis: a meta-analytic review.

Patients with schizophrenia often continue to experience disabling positive symptoms, despite adequate trials of medication. In these situations, patients may be prescribed an adjunctive medication, but a more effective choice may be cognitive-behavioral therapy (CBT). This review of 16 published articles from 12 randomized controlled trials found that CBT was associated with robust improvements in the positive symptoms of psychotic disorders. In addition, the improvements were sustained at follow-up, the authors reported.