ABSTRACT
OBJECTIVE: to determine the clinical profile of patients with myasthenia gravis (MG); followed at the Neuromuscular Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, and to compare it with other Brazilian case series. METHODS: sociodemographic and clinical data were collected from patients, and a systematic literature review performed, focusing on national studies on the clinical profile of MG patients. RESULTS: sixty nine patients were enrolled in the study. Fifty five (91%) subjects were female and the mean age (SD) was 37.6 (± 11.4) years. The mean disease duration was 14.1 years. Regarding treatment, prednisone was the most used strategy (64%), followed by the use of azathioprine (43%). There was no difference between thymectomized (42) and non-thymectomized (27) patients regarding disease severity and medication use. CONCLUSION: clinical and socio-demographic features of this MG sample from a University-based clinic resemble those reported in other Brazilian series and in the international literature.
Subject(s)
Myasthenia Gravis/diagnosis , Adolescent , Adult , Brazil , Cross-Sectional Studies , Female , Hospitals, University , Humans , Male , Middle Aged , Myasthenia Gravis/therapy , Severity of Illness Index , Socioeconomic Factors , Thymectomy , Young AdultABSTRACT
Summary Objective: to determine the clinical profile of patients with myasthenia gravis (MG); followed at the Neuromuscular Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, and to compare it with other Brazilian case series. Methods: sociodemographic and clinical data were collected from patients, and a systematic literature review performed, focusing on national studies on the clinical profile of MG patients. Results: sixty nine patients were enrolled in the study. Fifty five (91%) subjects were female and the mean age (SD) was 37.6 (±11.4) years. The mean disease duration was 14.1 years. Regarding treatment, prednisone was the most used strategy (64%), followed by the use of azathioprine (43%). There was no difference between thymectomized (42) and non-thymectomized (27) patients regarding disease severity and medication use. Conclusion: clinical and socio-demographic features of this MG sample from a University-based clinic resemble those reported in other Brazilian series and in the international literature. .
Objetivo: determinar o perfil clínico dos pacientes com miastenia gravis (MG) atendidos na Clínica de Doenças Neuromusculares do Serviço de Neurologia do Hospital das Clínicas da Universidade Federal de Minas Gerais, e comparar com outras séries de casos brasileiras. Métodos: foram coletados dados clínicos e sociodemográficos dos pacientes, e realizada revisão sistemática de literatura, focando em estudos nacionais sobre o perfil clínico de pacientes com MG. Resultados: sessenta e nove pacientes participaram do estudo, sendo 55 (91%) do sexo feminino, e a média de idade (desvio-padrão) de 37,6 (±11,4) anos. O tempo médio de doença foi de 14,1 anos. Em relação ao tratamento, o uso isolado de prednisona foi a estratégia mais adotada (64%), seguida do uso de azatioprina (43,3%). Não houve diferença entre os pacientes timectomizados (47) e não timectomizados (22) no que diz respeito à gravidade da doença e ao tratamento. Conclusão: as características clínicas e sociodemográficas da presente amostra de pacientes com MG de um serviço universitário assemelham-se às características de outras séries brasileiras e da literatura internacional. .
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Myasthenia Gravis/diagnosis , Brazil , Cross-Sectional Studies , Hospitals, University , Myasthenia Gravis/therapy , Severity of Illness Index , Socioeconomic Factors , ThymectomyABSTRACT
OBJECTIVE: To translate and to perform the cross-cultural adaptation of the "Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items" (MG-QOL15). METHOD: The original English version of the questionnaire was translated into Portuguese. This version was revised and translated back into English. Later, both English versions were compared and the divergences were corrected in the Portuguese text. At a second stage, ten patients with MG followed at the Neuromuscular Diseases Clinic from the University Hospital, Universidade Federal de Minas Gerais answered the questionnaire. The authors analyzed the difficulties and misunderstandings in the application of the questionnaire. RESULTS: The questions 8, 13 and 15 were considered difficult to understand and were modified in the final Portuguese version. Most patients (70%) had a total score above 25, and the statements 3, 8 and 9 showed the highest scores. CONCLUSION: The Brazilian version of the questionnaire MG-QOL15 seems to be a promising tool for the assessment of Brazilian patients with MG.
Subject(s)
Myasthenia Gravis/psychology , Quality of Life/psychology , Surveys and Questionnaires , Adolescent , Adult , Brazil , Cultural Characteristics , Female , Humans , Male , Middle Aged , Reproducibility of Results , Translations , Young AdultABSTRACT
Objective To translate and to perform the cross-cultural adaptation of the “Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items” (MG-QOL15). Method The original English version of the questionnaire was translated into Portuguese. This version was revised and translated back into English. Later, both English versions were compared and the divergences were corrected in the Portuguese text. At a second stage, ten patients with MG followed at the Neuromuscular Diseases Clinic from the University Hospital, Universidade Federal de Minas Gerais answered the questionnaire. The authors analyzed the difficulties and misunderstandings in the application of the questionnaire. Results The questions 8, 13 and 15 were considered difficult to understand and were modified in the final Portuguese version. Most patients (70%) had a total score above 25, and the statements 3, 8 and 9 showed the highest scores. Conclusion The Brazilian version of the questionnaire MG-QOL15 seems to be a promising tool for the assessment of Brazilian patients with MG. .
Objetivo Realizar a tradução e a adaptação transcultural do “Questionário de Qualidade de Vida Específico para Miastenia Gravis – 15 itens” (MG-QOL15). Método Inicialmente, foi realizada a tradução do instrumento original em inglês para o português. Esta versão foi revisada e retrotraduzida para o inglês. A versão retrotraduzida foi comparada à versão original em inglês, sendo corrigidas as divergências no texto em português. Em um segundo momento, dez pacientes com MG acompanhados na Clínica de Doenças Neuromusculares do Hospital das Clínicas da Universidade Federal de Minas Gerais responderam ao questionário. Na aplicação do questionário, os itens mal compreendidos foram analisados pelos autores. Resultados Os itens 8, 13 e 15 foram considerados de difícil compreensão e modificados na versão final em português. A maioria dos pacientes (70%) apresentou uma pontuação total superior a 25, sendo que os itens 3, 8 e 9 apresentaram os escores mais elevados. Conclusão A versão brasileira do MG-QOL15 é um instrumento promissor para a avaliação de pacientes brasileiros com MG. .