ABSTRACT
Developmental neurotoxicity can be ascribed to in utero exposure to exogenous substances or to exposure of the fetus to endogenous compounds that accumulate because of genetic mutations. One of the best recognized human neuroteratogens is ethanol. The Fetal Alcohol Syndrome (FAS) is characterized by growth deficiency, particular facial features, and central nervous system (CNS) dysfunctions (mental retardation, microencephaly and brain malformations). Abuse of toluene by pregnant women can lead to an embryopathy (fetal solvent syndrome, (FSS)) whose characteristics are similar to FAS. Phenylketonuria (PKU) is a genetic defect in phenylalanine (Phe) metabolism. Offspring of phenylketonuric mothers not under strict dietary control are born with maternal PKU (mPKU), a syndrome with similar characteristics as FAS and FSS. While ethanol has been shown to cause neuronal death, no such evidence is available for toluene or Phe and/or its metabolites. On the other hand, alterations in astrocyte proliferation and maturation have been found, mostly in in vitro studies, which may represent a potential common mode of action for at least some of the CNS effects found in FAS, mPKU, and FSS. Further in vivo and in vitro studies should validate this hypothesis and elucidate possible molecular targets.
Subject(s)
Maternal Exposure/adverse effects , Nervous System Diseases/embryology , Xenobiotics/adverse effects , Alcohol-Induced Disorders, Nervous System/embryology , Alcohol-Induced Disorders, Nervous System/etiology , Animals , Ethanol/adverse effects , Ethanol/toxicity , Female , Fetal Alcohol Spectrum Disorders/etiology , Fetal Alcohol Spectrum Disorders/pathology , Humans , Nervous System Diseases/etiology , Nervous System Diseases/genetics , Neurotoxicity Syndromes , Phenotype , Phenylketonuria, Maternal/complications , Pregnancy , Toluene/adverse effects , Toluene/toxicity , Xenobiotics/toxicitySubject(s)
Anxiety Disorders/etiology , Cerebral Infarction/complications , Panic , Temporal Lobe/blood supply , Adult , Cerebral Infarction/diagnostic imaging , Female , Hippocampus/blood supply , Hippocampus/diagnostic imaging , Humans , Temporal Lobe/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
A simplified method has been developed for performing radionuclide venography. The method makes use of the scintillation camera and a synchronized whole-body scanning bed. This technique permits a more integrated presentation of the data and is performed in conjunction with a standard ventilation-perfusion lung study. The total amount of 99mTc tracer injected is 2 mCi.