[The use of liposomes for "depositing" neurotropic preparations]. / Nekotorye aspekty ispol'zovaniia liposom dlia "deponirovaniia" neirotropnykh preparatov.

The possibility of formation of some liposomal neurotropic drugs was studied by 1H-NMR method. Experiments in animals on catalepsy and epidural anaesthesia confirmed this hypothesis.

[Is fluidization of the phospholipid bilayer by general anesthetics a reason for general anesthesia?]. / Iavliaetsia li indutsirovannoe obshchimi anestetikami razzhizhenie fosfolipidnogo bisloia prichinoi obshchei anestezii?

It was found that chlorpromazine and pipolfene potentiating general anaesthesia increase viscosity of phospholipid membrane in the region of polar headgroups and in the hydrophobic area near glycerol sceleton. These results (independently of potentiating mechanism) confuse a mechanism of anaesthetics action as increased fluidity of membrane phospholipids.

[Interactions of neurotropic drugs with phosphatidylcholine bilayer. Effects on sorption of polyvalent cations]. / Vzaimodeistvie neirotropnykh preparatov s fosfatidilkholinovym bisloem. Vliianie na sorbtsiiu polivalentnykh kationov.

It is found that neurotropic drugs, whose molecules have positively-charged amino groups and a considerable hydrophobic region (in size), can be incorporated into the phospholipid bilayers. This results in a decrease of the lifetime of Pr3+ cations in the membrane-associated state. No correlation was found to exist between local anaesthesia activity of the study drugs and its capability of displacement polyvalent cations from the membrane surface.