ABSTRACT
The absolute sensitivity signs of breast cancer to the drug have not yet been developed. Data from clinical trials on the study of experimental laboratory predictive markers of chemosensitivity: TOP2alpha (topoisomerase 2-alpha), beta-tubulin (subunit of dimeric protein tubulin), and BRCA1 (breast cancer 1) are contradictory and not numerous. Analysis of the results by the end of the clinical trial will allow examining the correlation between the effectiveness of preoperative taxane-chemotherapy and the level of experimental and standard molecular markets that is important for development of algorithm of treatment tactics for patients with locally advanced breast cancer.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biomarkers, Tumor/analysis , Breast Neoplasms/drug therapy , Breast Neoplasms/pathology , Adult , Aged , Antigens, Neoplasm/analysis , Breast Neoplasms/chemistry , Breast Neoplasms/surgery , DNA Topoisomerases, Type II/analysis , DNA-Binding Proteins/analysis , Drug Administration Schedule , Female , Humans , Immunohistochemistry , Middle Aged , Neoplasm Staging , Preoperative Period , Taxoids/administration & dosage , Treatment Outcome , Tubulin/analysisABSTRACT
The purpose of this study was to analyze the causes of false results in the ultrasound (US) and sonoelastography (SEG) examination of non-palpable and palpable lesions of the breast. The efficacy of diagnosis of non-palpable and palpable lesions by US and SEG was compared. 211 women with histologically confirmed focal breast lesions (146 non-palpable and 65 palpable) were included in the group. Women had a mean age of 52.0 +/- 13.6 years. The diameter of non-palpable lesions was less than 2 cm. Local mastopathy and medullar carcinoma were the reason of false results in most US. SEG allowed differentiating of these lesions. We found that SEG increased the specificity of diagnostics of non-palpable breast lesions by 19%.
Subject(s)
Breast Diseases/diagnosis , Breast/pathology , Elasticity Imaging Techniques , Ultrasonography, Mammary , Adult , Aged , Breast Diseases/diagnostic imaging , Breast Diseases/pathology , Breast Neoplasms/diagnosis , Female , Humans , Middle Aged , Predictive Value of Tests , Sensitivity and SpecificityABSTRACT
The study presents data on the treatment of lobular breast cancer. On the basis of the studied morphological and molecular-biological characteristics there were substantiated types of treatment that improved the survival of patients with invasive lobular carcinoma. It was showed the efficacy of systemic treatment for lobular breast cancer and also studied long-term outcomes of lobular breast cancer depending on the morphological and biological features.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biomarkers, Tumor/analysis , Breast Neoplasms/diagnosis , Breast Neoplasms/therapy , Carcinoma, Lobular/diagnosis , Carcinoma, Lobular/therapy , Adult , Aged , Breast Neoplasms/chemistry , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Carcinoma, Lobular/chemistry , Carcinoma, Lobular/mortality , Carcinoma, Lobular/pathology , Chemotherapy, Adjuvant , Disease Progression , Female , Humans , Lymphatic Metastasis , Middle Aged , Neoadjuvant Therapy/methods , Neoplasm Staging , Receptor, ErbB-2/analysis , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Survival Analysis , Treatment OutcomeABSTRACT
This is an analysis of the use of sonoelastography as part of complex instrumental diagnostic procedure (mammography, gray-scale and Doppler ultrasonography) for small breast tumors. A total of 126 patients with breast lesions below 20 mm in diameter were divided into two groups depending on lesion size. The first group consisted of women with 5-10 mm lesions (21 patients with carcinoma and 20 patients with benign tumors), the second group was characterized by 11-20 mm lesions (69 carcinoma patients and 16 patients with benign lesions). According to analysis results the diagnostic complex of gray-scale ultrasonography and sonoelastography is most sensitive, the sensitivity is higher in the second group (89.1% and 97.7% respectively). The complex ultrasonography procedure yielded better overall results than mammography in both patients' groups.
