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[Nonsteroidal antiinflammatory agents, IX: Racemic and optically active aryl(biphenylyl)hydroxypropionic acids (author's transl)]. / Nichtsteroidale Entzündungshemmer, 9. Mitt. Racem. und optisch aktive Aryl-biphenylyl-hydroxypropionsäuren.

Guarnieri, A; Burnelli, S; Varoli, L; Busacchi, I; Barbaro, A M; Gaiardi, M; Biagi, G L.

Arch Pharm (Weinheim) ; 314(8): 703-8, 1981 Aug.

Article in German | MEDLINE | ID: mdl-7294980

Subject(s)

Anti-Inflammatory Agents/chemical synthesis , Propionates/chemical synthesis , Animals , Male , Propionates/pharmacology , Rats , Rats, Inbred Strains , Stereoisomerism

[Non-steroidal anti-inflammatory agents. VIII. 3-(4-biphenyly)-2-hydroxybutyric acid]. / Antiinfiammatori non steroidei. Nota VIII - Acido 3-(4-bifenilil)-2-ossibutirrico.

Guarnieri, A; Scapini, G; Burnelli, S; Busacchi, I; Varoli, L.

Farmaco Sci ; 34(8): 704-8, 1979 Aug.

Article in Italian | MEDLINE | ID: mdl-467635

Subject(s)

Anti-Inflammatory Agents/chemical synthesis , Hydroxybutyrates/chemical synthesis , Animals , Anti-Inflammatory Agents/administration & dosage , Biphenyl Compounds/administration & dosage , Biphenyl Compounds/chemical synthesis , Crystallization , Hydroxybutyrates/administration & dosage , Injections, Subcutaneous , Lethal Dose 50 , Magnetic Resonance Spectroscopy , Rats

[Non-steroid anti-inflammatory agents. VII. Optically active homologues of 3-(4-biphenylyl)-3-hydroxypropionic acid]. / Antiinfiammatori non steroidei. Nota VII - Omologhi otticamente attivi dell'acido 3-(4-bifenilil)-3-ossipropionico.

Guarnieri, A; Burnelli, S; Busacchi, I; Varoli, L.

Boll Chim Farm ; 118(2): 88-93, 1979 Feb.

Article in Italian | MEDLINE | ID: mdl-454537

Subject(s)

Anti-Inflammatory Agents/chemical synthesis , Biphenyl Compounds/chemical synthesis , Propionates/chemical synthesis , Animals , Mice , Optical Rotation , Rats

[Non-steroidal anti-inflammatory agents. V. Optically active 4-biphenylyloxybutyric and 4-biphenylylglycolic acids]. / Antiinfiammatori non steroidei. Nota V - Acidi 4-bifenililossibutirrici e 4-bifenililglicolici otticamente attivi.

Guarnieri, A; Burnelli, S; Andreani, A; Busacchi, I; Barbaro, A M; Gaiardi, M.

Farmaco Sci ; 33(10): 761-9, 1978 Oct.

Article in Italian | MEDLINE | ID: mdl-744235

ABSTRACT

The synthesis and the resolution of the enantiomers of (+/-)2-(4-biphenylyl)-4-oxybutyric and (+/-)4-(4-biphenylyl)-2-oxybutyric acids and the resolution of the enantiomers of (+/-)2-(4-biphenylyl)-2-oxybutyric and (+/-)4-biphenylylglycolic acids are described. The potassium salts of each enantiomer were submitted to preliminary assays of antiphlogistic activity.

Subject(s)

Anti-Inflammatory Agents/chemical synthesis , Butyrates/chemical synthesis , Glycolates/chemical synthesis , Animals , Butyrates/pharmacology , Edema/physiopathology , Glycolates/pharmacology , Male , Rats , Stereoisomerism

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