ABSTRACT
The aim of the study was to investigate changes in the oral cavity and the gastroesophageal zone of the patients receiving rabeprazol, a proton pump inhibitor (PPI). The subjects were 88 patients with gastroesophageal reflux disease (GERD), who had changes in the oral cavity typical of this disease. The patients were divided into four groups. Group I included patients with non-erosive reflux disease; the other three groups were formed according to the degree of the severity of reflux esophagitis in accordance with Los Angeles classification of GERD: A, B, and C. The patients were administered rabeprazol as a PPI. The study found that oral cavity changes are associated with the degree of the gastroesophageal reflux. The study demonstrated high efficacy of rabeprazol in GERD patients with oral cavity changes.
Subject(s)
Gastroesophageal Reflux/complications , Stomatitis/etiology , 2-Pyridinylmethylsulfinylbenzimidazoles , Benzimidazoles/therapeutic use , Enzyme Inhibitors/therapeutic use , Esophagus/metabolism , Female , Follow-Up Studies , Gastroesophageal Reflux/drug therapy , Gastroesophageal Reflux/metabolism , Humans , Hydrogen-Ion Concentration , Male , Mouth/drug effects , Mouth/metabolism , Mouth/pathology , Omeprazole/analogs & derivatives , Omeprazole/therapeutic use , Proton-Translocating ATPases/antagonists & inhibitors , Rabeprazole , Saliva/metabolism , Severity of Illness Index , Stomatitis/pathology , Stomatitis/prevention & control , Treatment OutcomeABSTRACT
Gastroesophageal reflux disease (GERD) is a wide spread disease characterized by distinct clinical polymorphism manifesting with various symptoms and/or inflammatory changes of a distal portion of the esophagus. Current first-line therapy in GERD consists in administration of proton pump inhibitors (PPI) which promote faster relief of the symptoms and healing of erosive-ulcerous lesions of esophageal mucosa in GERD patients. Clinical efficacy of standard and novel PPI is compared. Wide use of PPI and their long-term courses require further study of PPI side effects which now lack attention from the clinical researchers.
Subject(s)
Gastroesophageal Reflux/drug therapy , Omeprazole/analogs & derivatives , Proton Pump Inhibitors , 2-Pyridinylmethylsulfinylbenzimidazoles , Benzimidazoles/therapeutic use , Enzyme Inhibitors/therapeutic use , Humans , Lansoprazole , Omeprazole/therapeutic use , Pantoprazole , Rabeprazole , Sulfoxides/therapeutic use , Treatment OutcomeSubject(s)
AIDS-Related Opportunistic Infections , Antiviral Agents/therapeutic use , Esophagitis , Herpes Simplex , Herpesvirus 1, Human/drug effects , AIDS-Related Opportunistic Infections/drug therapy , AIDS-Related Opportunistic Infections/virology , Antiviral Agents/adverse effects , Esophagitis/drug therapy , Esophagitis/virology , Herpes Simplex/drug therapy , Herpes Simplex/virology , Herpesvirus 1, Human/isolation & purification , HumansABSTRACT
AIM: To investigate the prevalence of gastroesophageal reflux disease (GERD) among patients with bronchial asthma (BA) and to determine the effects of omeprazole therapy on the outcome of asthma in patients with GERD. MATERIAL AND METHODS: 117 BA patients were examined. Those who had a concomitant GERD were divided into two groups to receive outpatiently omeprazole 40 mg/day or placebo for 8 weeks. Spirometry was performed before and after the treatment. Clinical indices were calculated by daily summarizing of pulmonary (CIEI I) and gastric (CIEI II) symptoms improvement. RESULTS: The trial showed a significant correlation between CIEI I and CIEI II (r = 0.574, p < 0.001) during 8-week omeprazole therapy. The analysis of PEV and FEV1 dynamics showed a significant improvement (p < 0.05) of bronchial conduction in BA patients receiving omeprazole vs placebo. CONCLUSION: A significant correlation exists between the severity of gastroesophageal refluxes and bronchoobstructive syndrome in BA and GERD patients. Omeprazole treatment of such patients relieves BA and GERD symptoms.
Subject(s)
Asthma/complications , Gastroesophageal Reflux/drug therapy , Omeprazole/therapeutic use , Adult , Gastroesophageal Reflux/complications , Humans , Middle Aged , Placebos , Treatment OutcomeABSTRACT
Adaptive reactions were studied in 80 patients with acute pneumonia. In the hospital 94.1% patients showed reactions of stress and incomplete reactions of training and activation. With improvement of the clinical condition the number of stress reactions reduces, while the number of physiological reactions of training and activation increased. The stress reaction is an unfavourable factor as to transition of acute pneumonia into chronic unspecific pulmonary diseases. These studies may be of value for evaluation of the prognosis and care of acute pneumonia.
Subject(s)
Adaptation, Physiological , Pneumonia/physiopathology , Acute Disease , Humans , Leukocyte Count , Physical Therapy Modalities/methods , Pneumonia/blood , Pneumonia/rehabilitation , Prognosis , Stress, Physiological/blood , Stress, Physiological/physiopathology , Stress, Physiological/rehabilitationABSTRACT
The paper presents clinical and instrumental evidence on 47 patients with hepatic cirrhosis. The revealed ventilatory disorders and worse bronchial permeability closely correlated with the degree of pulmonary hypertension which in its turn depended on portal hypertension degree. Pulmonary hypertension decreased with a decline in the activity of the pathological process in the liver due to treatment. External respiration insufficiency observed in hepatic cirrhosis contributes to the onset of arterial hypoxemia and hypoxic impairment of the liver activating in it a pathological process. It is recommended that such patients should receive a combined treatment incorporating oxygen therapy, calcium antagonists, antioxidants.
Subject(s)
Hypertension, Pulmonary/diagnostic imaging , Liver Cirrhosis/physiopathology , Pulmonary Circulation/physiology , Respiration/physiology , Respiratory Insufficiency/diagnostic imaging , Ventricular Function, Right/physiology , Adult , Aged , Echocardiography, Doppler , Humans , Hypertension, Pulmonary/etiology , Liver Cirrhosis/complications , Liver Cirrhosis/diagnostic imaging , Middle Aged , Respiratory Insufficiency/etiologySubject(s)
Lung Diseases, Obstructive/complications , Respiratory Insufficiency/etiology , Adrenal Cortex/physiopathology , Adrenal Cortex Function Tests , Adrenal Cortex Hormones/therapeutic use , Adult , Female , Humans , Lung Diseases, Obstructive/physiopathology , Male , Middle Aged , Pulmonary Circulation , Pulmonary Heart Disease/drug therapy , Pulmonary Heart Disease/etiologySubject(s)
Pulmonary Emphysema/diagnosis , Humans , Lung/diagnostic imaging , Lung/physiopathology , Pleura/diagnostic imaging , Pneumothorax/etiology , Pulmonary Emphysema/complications , Pulmonary Emphysema/etiology , Pulmonary Emphysema/physiopathology , Pulmonary Emphysema/therapy , Radiography , Radionuclide Imaging , Respiratory Function TestsABSTRACT
The method of perfusion scanning of the lungs with albumin microaggregate 131I was used for studying the state of pulmonary blood flow in patients with acute pneumonia (AP). The outcome of the disease was chronic non-specific lung disease (CNLD). The results of study demonstrated the improvement of microcirculation by the time of discharge from a hospital, but in 54.2 per cent of the patients blood flow was reduced. It was proved that reduced blood flow, by the time of discharge, together with impaired external respiration function, X-ray changes and biochemical blood shifts are the unfavourable factors with respect to prognosis which contribute to the transition of AP into CNLD. Combined therapy of AP should include measures directed to the improvement of pulmonary microcirculation.