Does patient load affect clinical outcome of burn patients in specialized centers? An analysis of the German Burn Registry.

Hospital volume has been identified as an independent outcome parameter for a number of medical fields and surgical procedures, and there is a tendency to increase required patient numbers for center verification. However, the existing literature does not support a clear correlation between patient load and clinical outcome in adult burn care and recent data from Germany does not exist. We therefore evaluated the effect of patient volume in German burn centers on clinical outcome. Patient data was extracted from the German Burn Registry from 2015 to 2018. For better inter-center comparability, solely burn patients with a TBSA ≥ 10% were included. Mortality, number of surgeries and length of stay (LOS) were evaluated with respect to burn center patient volume. Burn center volume was divided into two and three groups. A total of 2718 patients with a TBSA ≥ 10% were admitted to the participating 17 burn centers. Independent from the division of patient data into either 2 or 3 groups, the TBSA and ABSI score-related severity of burn injuries were comparable between groups. There was no significant difference in mortality due to center size. Nevertheless, patients treated in large volume burn centers showed a significantly increased LOS (+4.5 days, [1.9-7.2] CI, p = 0.001) and required significantly more surgeries (+0.5 surgeries [0.2-0.8] CI, p = 0.002) when compared to the small volume centers. A similar phenomenon regarding mortality and LOS (p 0.001) was observed after dividing the centers into two groups. Interestingly a division into three groups showed significant differences with the best outcome for patients in medium-volume centers. Nevertheless, mortality did not differ significantly. Therefore, our data demonstrates that in contrast to many other medical fields, outcome and mortality are not automatically improved in burn care by simply increasing the patient load, at least in centers treating 20-100 BICU patients/year.

Is UV radiation beneficial in postburn wound healing?

Currently strict ultraviolet (UV) light avoidance strategies and utilizing sunblock containing products are generally advocated during the reepithelialization process as well as after wound closure. These recommendations are guided by a common appreciation of UV radiation as a predominant cause of skin cancer development. It is possible however that the currently accepted practice of near continuous UV protection abrogates the normal cutaneous response to injury, with melanocyte redistribution and pigmentation creating hypopigmented scars. We hypothesize that judicious UV exposure might in fact be beneficial for wound healing and skin homeostasis. UV light should be investigated as a potential modulator of keratinocyte-melanocyte cross-talk in wound healing. In vitro studies will have to prove whether UV radiation induced melanocyte activation might have a stimulatory paracrine effect on keratinocyte proliferation which could beneficially affect wound healing. We further hypothesize that UV exposure to wounds might stimulate and restore normal melanocyte distribution and melanin content in reepithelialized wounds preventing hypopigmentation. Furthermore, exposure of reepithelialized wounds to UV light might exert a photo protective effect in the skin by the production of melanin. This in turn may protect the epidermis from UV-induced damage and carcinogenesis. It is therefore proposed that moderate UV exposure should be commenced early in the healing process of cutaneous wounds. At present, current practice and literature do not support the notion that UV-sun block is necessary in postburn scar management. Burn scars do not seem to exert an enhanced risk for melanomagenesis, the occurrence of which has only very rarely been reported in burn scars. Different mutations in susceptibility genes or in genes involved in the control of the cell cycle or maintenance of cellular integrity which are UV radiation independent are involved in the initiation and promotion steps of skin cancer.

[The use of mamma MRI volumetry to evaluate the rate of fat survival after autologous lipotransfer]. / MRT-Volumetrie der Mamma zur Kontrolle der Fettresorptionsrate nach autologem Lipotransfer.

INTRODUCTION: Autologous lipotransfer is becoming more and more popular in plastic surgery. Until now the rate of fat survival was merely estimated by the surgeon and no proven data exist. To assess this surgical method a reproducible and exact tool for volume analysis is necessary. PATIENTS AND METHODS: The volume of silicone implants was calculated in six healthy patients with silicone breast augmentation using the BrainLab(c) I Plan Software. In the same technique volumetry was performed in 10 patients before and six months after autologous lipotransfer using the water-jet assisted liposuction (BEAULI) to harvest the fat tissue. RESULTS: Comparison of the implant volumes calculated with MRI volumetry with the official volumes given by the manufacturer showed a very low mean deviation of 2.1+/-1.5%. Preoperative and postoperative MRI volumetry in patients after autologous lipotransfer revealed a mean volume augmentation of 147+/-18 mL. In these patients 72+/-11% of the transplanted fat tissue persisted in the area of injection six month after surgery. CONCLUSION: MRI volumetry is a useful tool for the fast, exact and reproducible volume analysis of breast tissue. Especially after autologous lipotransfer, where MRI examinations are performed on a regular basis to exclude possible complications, the use of these data to evaluate the rate of fat tissue survival is appealing and due to the high exactness of the method also reasonable.

[The Biobrane glove in burn wounds of the hand. Evaluation of the functional and aesthetic outcome and comparison of costs with those of conventional wound management]. / Der Biobrane-Handschuh bei Verbrennungen der Hand. Bewertung des funktionellen und kosmetischen Ergebnisses und Kostenvergleich zur konventionellen Therapie.

BACKGROUND: While use of biocomposite temporary dressings in burn wounds is common practice, the complex anatomic structures of the hand make this treatment option challenging. For this reason, the Biobrane ((R)) Glove (Smith&Nephew) has been developed. However, limited information regarding burn treatment with Biobrane ((R)) Gloves can be found in the literature. PATIENTS AND METHODS: Functional and cosmetic outcomes of 13 second degree burn wounds of the hand in 10 patients treated with Biobrane ((R)) Gloves were evaluated using the Vancouver scar scale (VSS) and the DASH-score (disabilities of the arm, shoulder and hand). We evaluated wound healing times and questioned patients about pain related to Biobrane ((R)) Glove treatment in comparison to conventionally managed second degree burn wounds in other parts of the body and about acceptance of Biobrane ((R)) Glove treatment. In addition, we estimated the costs for use and wound management time for both Biobrane ((R)) Glove treatment and conventional wound management for 14 days. RESULTS: Burn wounds treated with Biobrane ((R)) Gloves had excellent functional and cosmetic outcomes [DASH score median of 0 (min. 0; max. 3.33) and VSS median of 3 (min. 0; max. 5)]. Wound healing times were lower (mean 9 days). According to patients' response to overall acceptance, 90% responded as being "very satisfied" with Biobrane ((R)) Glove treatment and 75% responded that Biobrane ((R)) Glove treatment was "much less painful" compared to conventional burn management. The material costs of the Biobrane ((R)) Glove treatment, over 14 days, were approx. double compared to conventional wound management costs. In contrast, the time required for conventional wound management over 14 days was four times longer than for treatment with Biobrane ((R)) Gloves. Thus, taking personnel expenses into consideration, total costs of Biobrane ((R)) Glove treatment are comparable to those of conventional wound management. CONCLUSION: Biobrane ((R)) Glove treatment of hand burns resulted in excellent functional and cosmetic outcomes, reduced pain compared to conventional wound management and high overall patient satisfaction. In conjunction with a significant reduction in wound management time, the Biobrane ((R)) Glove is an important and cost neutral tool in the treatment of second degree burn wounds of the hand.

Mannose-binding lectin plays a critical role in myocardial ischaemia and reperfusion injury in a mouse model of diabetes.

AIMS/HYPOTHESIS: Diabetic patients are at increased risk of cardiomyopathy, acute myocardial infarction and loss of cardiac progenitor cells (CPCs), but the aetiology is poorly understood. We hypothesised a significant role for mannose-binding lectin (MBL) in cardiomyopathies associated with hyperglycaemia. METHODS: The role of MBL in myocardial ischaemia and reperfusion (MI/R) injury was investigated in wild-type (WT) and MBL-null mice following 2 weeks of streptozotocin-induced hyperglycaemia. RESULTS: Hyperglycaemic WT mice presented with significantly decreased left ventricular ejection fractions and increased serum troponin I levels and myocardial inflammation compared with non-diabetic WT mice following MI/R. Hyperglycaemic MBL-null mice or insulin-treated diabetic WT mice were significantly protected from MI/R injury compared with diabetic WT mice. In an additional study using diabetic WT mice, echocardiographic measurements demonstrated signs of dilative cardiomyopathy, whereas heart:body weight ratios suggested hypertrophic cardiac remodelling after 2 weeks of hyperglycaemia. Immunohistochemical analysis of CPCs showed significantly lower numbers in diabetic WT hearts compared with non-diabetic hearts. Insulin-treated diabetic WT or untreated diabetic MBL-null mice were protected from dilative cardiomyopathy, hypertrophic remodelling and loss of CPCs. CONCLUSIONS/INTERPRETATION: These data demonstrate that MBL may play a critical role in diabetic MI/R injury. Further, the absence of MBL appears to inhibit hypertrophic remodelling and hyperglycaemia-induced loss of CPCs after just 2 weeks of hyperglycaemia in mice.