1.
Bioorg Med Chem
; 19(1): 663-76, 2011 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-21093273
ABSTRACT
The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activity. The detailed synthesis and in vitro activity and ADME profile of compounds is described, which represent a previously undisclosed triple reuptake inhibitor chemotype.
Subject(s)
Naphthalenes/chemical synthesis , Naphthalenes/pharmacology , Neurotransmitter Uptake Inhibitors/chemical synthesis , Neurotransmitter Uptake Inhibitors/pharmacology , Animals , Antidepressive Agents/chemical synthesis , Antidepressive Agents/pharmacology , Disease Models, Animal , Dopamine/metabolism , Drug Evaluation, Preclinical , Mice , Norepinephrine/metabolism , Serotonin/metabolism
2.
Methods Mol Med
; 93: 175-219, 2004.
Article
in English
| MEDLINE
| ID: mdl-14733334