Subject(s)
Herpes Simplex/diagnosis , Molluscum Contagiosum/diagnosis , Adult , Diagnosis, Differential , Female , HumansABSTRACT
Women with recurrent vaginal candidosis were treated until the infection cleared and were then given one clotrimazole 500 mg vaginal tablet a month or an identical placebo as prophylaxis. Of 21 women who received placebo, 16 developed symptoms or signs within three months, compared with nine of 17 women given active treatment. Women who relapsed were treated and then given active prophylaxis once a month. Of 30 women given such treatment, 13 relapsed within three months. Women who relapsed were treated and then given two clotrimazole 500 mg vaginal tablets a month. Of 17 women given prophylaxis twice a month, four developed symptoms or signs within three months, but 10 remained clear for 12 months. No appreciable difference was seen in the incidence of mycological recurrence between the different regimens; within three months over half the women in all treatment groups had become recolonised.
Subject(s)
Candidiasis, Vulvovaginal/prevention & control , Adolescent , Adult , Candidiasis, Vulvovaginal/drug therapy , Clinical Trials as Topic , Clotrimazole/administration & dosage , Clotrimazole/therapeutic use , Female , Humans , Middle Aged , RecurrenceABSTRACT
Herpes simplex virus type 2 is demonstrated in routine cervical smears by immunocytochemistry. Optimum antibody dilution and suitable fixation were determined and immunostaining results were found to compare favourably with those obtained by screening Papanicolaou-stained smears or by virus culture methods (virus isolation). Results obtained for immunostaining of smears from 158 patients agreed with those of virus isolation in 47 of 50 cases where virus isolation was performed. It is suggested that this immunocytochemical technique is valuable in detection of Herpes simplex virus in cervical smears, offering an inexpensive and rapid laboratory diagnosis with advantage to both patient and clinician.
Subject(s)
Herpes Genitalis/diagnosis , Papanicolaou Test , Simplexvirus/isolation & purification , Vaginal Smears , Biopsy , Cervix Mucus/microbiology , Cervix Uteri/microbiology , Cervix Uteri/pathology , Female , Herpes Genitalis/pathology , Humans , Immunoenzyme Techniques , Male , Simplexvirus/immunology , Virus CultivationABSTRACT
Twenty-four episodes of genital herpes in 22 men, all confirmed by virus isolation, were studied in a double blind trial. They were treated either with 3% adenine arabinoside (Ara-A) in petrolatum ointment base or with the base alone applied four times daily for one week. The lesions were counted and sketeched on days 0, 2, and 7. There was no demonstrable advantage to be gained from the use of Ara-A ointment. The results of the Papanicolaou smears and virus isolation agreed in the diagnosis of 75% of cases. The presence of continuing lesions or fresh ones in some patients after the acute phase of the initial or recurrent attack of herpes necessitates the man taking precautions on resuming sexual intercourse.
