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Rheum Dis Clin North Am ; 49(2): 463-481, 2023 05.
Article in English | MEDLINE | ID: mdl-37028847

ABSTRACT

Systemic sclerosis (SSc) -related calcinosis can be a debilitating, constantly painful, poorly understood vascular complication of calcium hydroxyapatite deposition in soft tissue structures that affects approximately 40% of both limited and diffuse cutaneous SSc subtypes. This publication describes the iterative and multitiered international qualitative investigations that yielded remarkable insights into natural history, daily experience, and complications of SSc-calcinosis providing pivotal information for health management. Patient-driven question development and field testing, according to Food and Drug Administration guidance, propelled the development of a patient-reported outcome measure for SSc-calcinosis, the Mawdsley Calcinosis Questionnaire.


Subject(s)
Calcinosis , Scleroderma, Systemic , Humans , Scleroderma, Systemic/complications , Calcinosis/complications , Surveys and Questionnaires , Patient Outcome Assessment
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