ABSTRACT
The ocular absorption, elimination and toxicity of 12.5 mg of methotrexate in 0.5 cc administered subconjunctivally was studied in the dog. The purpose of this study was to establish ocular pharmacokinetics for treatment of intraocular tumours in dogs. Drug levels were measured in ocular compartments, and serum at 1,2,4,6,8 and 12 hours respectively. Tumoricidal concentrations of the drug were attained in the anterior chambers of the injected eyes up to and including six hours postinjection. Consistent signs of toxicity were anorexia, vomiting, weight loss and leukopenia. Local ocular toxicity following subconjunctival injection was minimal conjunctival hyperemia lasting up to 48 hours.
ABSTRACT
An unusual clinical case of panophthalmitis in the dog is discussed. Failure of resolution led to enucleation. Histopathology study showed an intraocular foreign body, probably a grass awn, that had migrated into the eye and established a panophthalmitis.
Subject(s)
Dog Diseases/diagnosis , Eye Foreign Bodies/veterinary , Animals , Dogs , Eye Foreign Bodies/diagnosis , FemaleABSTRACT
Rabbits were given dicloxacillin subconjunctively. Very high levels of the drug were recovered from the aqueous humor. Soon after injection, corneal opacification, epithelial sloughing and conjunctival necrosis were noted clinically. The globes were studied histopathologically.
