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1.
Front Oncol ; 9: 669, 2019.
Article in English | MEDLINE | ID: mdl-31404273

ABSTRACT

Cancer is a complex disease, and its study requires deep understanding of several biological processes and their regulation. It is an accepted fact that non-coding RNAs are vital components of the regulation and cross-talk among cancer-related signaling pathways that favor tumor aggressiveness and metastasis, such as neovascularization, angiogenesis, and vasculogenic mimicry. Both long non-coding RNAs (lncRNAs) and micro-RNAs (miRNAs) have been described as master regulators of cancer on their own; yet there is accumulating evidence that, besides regulating mRNA expression through independent mechanisms, these classes of non-coding RNAs interact with each other directly, fine-tuning the effects of their regulation. While still relatively scant, research on the lncRNA-miRNA-mRNA axis regulation is growing at a fast rate, it is only in the last 5 years, that lncRNA-miRNA interactions have been identified in tumor-related vascular processes. In this review, we summarize the current progress of research on the cross-talk between lncRNAs and miRNAs in the regulation of neovascularization, angiogenesis and vasculogenic mimicry.

2.
Int J Mol Sci ; 19(9)2018 Sep 11.
Article in English | MEDLINE | ID: mdl-30208633

ABSTRACT

Predicting response to systemic treatments in breast cancer (BC) patients is an urgent, yet still unattained health aim. Easily detectable molecules such as long non-coding RNAs (lncRNAs) are the ideal biomarkers when they act as master regulators of many resistance mechanisms, or of mechanisms that are common to more than one treatment. These kinds of markers are pivotal in quasi-personalized treatment selection, and consequently, in improvement of outcome prediction. In order to provide a better approach to understanding development of disease and resistance to treatments, we reviewed current literature searching for lncRNA-associated systemic BC treatments including endocrine therapies, aromatase inhibitors, selective estrogen receptor modulators (SERMs), trastuzumab, paclitaxel, docetaxel, 5-fluorouracil (5-FU), anthracyclines, and cisplatin. We found that the engagement of lncRNAs in resistance is well described, and that lncRNAs such as urotelial carcinoma-associated 1 (UCA1) and regulator of reprogramming (ROR) are indeed involved in multiple resistance mechanisms, which offers tantalizing perspectives for wide usage of lncRNAs as treatment resistance biomarkers. Thus, we propose this work as the foundation for a wide landscape of functions and mechanisms that link more lncRNAs to resistance to current and new treatments in years of research to come.


Subject(s)
Antineoplastic Agents/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/genetics , Drug Resistance, Neoplasm , Gene Expression Regulation, Neoplastic , RNA, Long Noncoding/genetics , Animals , Antineoplastic Agents/pharmacology , Breast/drug effects , Breast/metabolism , Breast/pathology , Breast Neoplasms/pathology , Female , Humans , Molecular Targeted Therapy/methods
3.
ScientificWorldJournal ; 2012: 570278, 2012.
Article in English | MEDLINE | ID: mdl-22919337

ABSTRACT

Tuberculosis (TB) is one of the oldest human diseases that still affects large population groups. According to the World Health Organization (WHO), there were approximately 9.4 million new cases worldwide in the year 2010. In Mexico, there were 18,848 new cases of TB of all clinical variants in 2010. The identification of clusters in space-time is of great interest in epidemiological studies. The objective of this research was to identify the spatial and temporal distribution of TB during the period 2006-2010 in the State of Mexico, using geographic information system (GIS) and SCAN statistics program. Nine significant clusters (P < 0.05) were identified using spatial and space-time analysis. The conclusion is that TB in the State of Mexico is not randomly distributed but is concentrated in areas close to Mexico City.


Subject(s)
Tuberculosis/epidemiology , Humans , Mexico/epidemiology , Prevalence
4.
Salud pública Méx ; 38(5): 323-331, sept.-oct. 1996. tab
Article in Spanish | LILACS | ID: lil-184215

ABSTRACT

Objetivo. Describir las características sociodemográficas y de atención médica de las personas que murieron por tuberculosis pulmonar en el estado de Veracruz, México, durante 1993, y comparar dichas características entre quienes fueron usuarios de servicios de salud públicos y privados. Material y métodos. Se seleccionaro 300 sujetos a través de su certificado de defunción y se realizó una entrevista a su familiares más cercanos utilizando la autopsia verbal. Resultados. La información obtenida señala que aproximadamente a la mitad de personas fallecidas se les diagnóstico tuberculosis por primera vez el mismo año en que murieron. Aproximadamente el 50 por ciento de los familiares informó que aquéllos habían abandonado el tratamiento al menos una vez y el 40 por ciento abusaba en el consumo de alcohol. Las características sociodemográficas muestran que las personas fallecidas pertenecieron a los grupos sociales más desprotegidos, dada la gran proporción de analfabetas o escolaridad nula (35 por ciento) y la carencia de trabajo remunerado (67 por ciento). No se encontraron diferencias importantes entre las que asistieron a los servicios de salud privados y las que acudieron a los oficiales. Conclusiones. Se destacan como hallazgos el alto porcentaje de pacientes que son diagnosticados en etapas muy avanzadas de su enfermedad; el alcoholismo; los efectos indeseables de los medicamentos como causa de abandono; y las enfermedades concomitantes al momento del diagnóstico


Objetivo. Describir las características sociodemográficas y de atención médica de las personas que murieron por tuberculosis pulmonar en el estado de Veracruz, México, durante 1993, y comparar dichas características entre quienes fueron usuarios de servicios de salud públicos y privados. Material y métodos. Se seleccionaron 300 sujetos a través de su certificado de defunción y se realizó una entrevista a sus familiares más cercanos utilizando la autopsia verbal. Resultados. La información obtenida señala que aproximadamente a la mitad de las personas fallecidas se les diagnosticó tuberculosis por primera vez el mismo año en que murieron. Aproximadamente el 50% de los familiares informó que aquéllos habían abandonado el tratamiento al menos una vez y el 40% abusaba en el consumo de alcohol. Las características sociodemográficas muestran que las personas fallecidas pertenecieron a los grupos sociales más des-protegidos, dada la gran proporción de analfabetas o escolaridad nula (35%) y la carencia de trabajo remunerado (67%). No se encontraron diferencias importantes entre las que asistieron a los servicios de salud privados y las que acudieron a los oficiales. Conclusiones. Se destacan como hallazgos el alto porcentaje de pacientes que son diagnosticados en etapas muy avanzadas de su enfermedad; el alcoholismo; los efectos indeseables de los medicamentos como causa de abandono; y las enfermedades concomitantes al momento del diagnóstico.


Subject(s)
Humans , Male , Female , Tuberculosis, Pulmonary/mortality , Mortality Registries/statistics & numerical data , Risk Factors , Cause of Death , Health Services , Mexico/epidemiology , Statistical Distributions , Socioeconomic Factors
5.
Rev. saúde pública ; 28(3): 198-203, jun. 1994. tab
Article in Spanish | LILACS | ID: lil-137828

ABSTRACT

Com a intençäo de apoiar a tomada de decisöes e melhorar o benefício, ao priorizar necessidades, discute o modelo de inversäo-produçäo-consumo (IPC), o qual tenta medir o impacto socioeconômico da mortalidade. Esse tipo de avaliaçäo toma em conta a idade ao morrer e a futura produtividade potencial, gerando perdas ou ganhos à sociedade, dependendo da etapa da vida quando ocorreu a morte. Ilustra para o México o impacto das diferentes causas de morte e compara com a importância relativa, partindo da ordenaçäo com as taxas da mortalidade e o indicador de anos de vida perdidos (IVAPP). Ao ordenar por taxas, observa que as doenças do coraçäo, acidentes e tumores säo as primeiras causas. Entretanto, o tradicional indicador de anos de vida potencialmente perdidos demonstra que estäo em primeiro lugar as causas de morte em idades menores. O IAVPPipc entretanto, dá maior importância às infecçöes, aos acidentes e aos homicídios, partindo do ponto de vista da produçäo e consumo


Subject(s)
Humans , Mortality , Cause of Death , Health Priorities , Value of Life , Quality of Life , Indicators of Morbidity and Mortality , Mexico , Life Expectancy , Decision Making
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