ABSTRACT
PURPOSE: To report a case of iris melanocytoma mimicking the Cogan-Reese syndrome. METHODS: A 37-year-old woman presented with pigmentary glaucoma in her left eye. There was diffuse pigmentary dispersion in the anterior segment, pedunculated pigmented nodules on the anterior iris surface, mild iris atrophy, and ectropion iridis. Neither intrinsic vasculature nor a sector cataract was found. The angle was open with marked trabecular pigmentation and no anterior synechiae. The intraocular pressure was 30 mmHg with maximum medical treatment and there was glaucomatous optic atrophy. The differential diagnosis included iris pigmented tumor and iridocorneal endothelial syndrome (Cogan-Reese syndrome). An iris biopsy was performed for diagnostic purposes. RESULTS: Histologic diagnosis after evaluation of the specimen was iris melanocytoma. CONCLUSIONS: This case presents signs considered quasi-pathognomonic of iridocorneal endothelial syndrome (Cogan-Reese syndrome): glaucoma, mild iris atrophy associated with pedunculated iris nodules, and ectropion iridis. Therefore, iris melanocytoma can present with features that mimic the Cogan-Reese syndrome.
Subject(s)
Corneal Diseases/diagnosis , Exfoliation Syndrome/diagnosis , Iris Diseases/diagnosis , Iris Neoplasms/diagnosis , Nevus, Pigmented/diagnosis , Pigment Epithelium of Eye/pathology , Adult , Atrophy , Diagnosis, Differential , Endothelium, Corneal/pathology , Female , Glaucoma, Open-Angle/diagnosis , Humans , Iris/pathology , Melanocytes/pathology , Trabecular Meshwork/pathologyABSTRACT
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Subject(s)
Female , Middle Aged , Humans , Teratoma/complications , Glioma/pathology , Ovarian Neoplasms/complications , Peritoneal Neoplasms/pathology , Biomarkers, Tumor/analysis , Neoplasm Metastasis/pathologyABSTRACT
We describe a 60-year-old man with idiopathic portal hypertension and hepatic angiosarcoma. The patient had taken an arsenical preparation for the treatment of psoriasis for 10 years. Five cases of this association have been reported previously; in one only, exposure to arsenical salts was present.
Subject(s)
Arsenicals/adverse effects , Hemangiosarcoma/chemically induced , Hypertension, Portal/chemically induced , Liver Neoplasms/chemically induced , Arsenicals/therapeutic use , Humans , Male , Middle Aged , Psoriasis/drug therapyABSTRACT
A 28 year-old female patient was operated for acute abdominal pain. At the surgical intervention the mesenteric nodes turned out to be enlarged and the appendix was apparently normal. Microscopically, the changes observed were of the Rosai-Dorfman disease type in the appendix as well as in the nodes. A salmonella D was cultivated in the mesenteric nodes. This association, which has not been described in the literature, permits us to comment clinicopathological aspects, poorly defined, with special reference to the possibility that some instances of Rosai-Dorfman disease could be secondary to an infectious process.
