1.
Int J Lab Hematol
; 30(1): 68-70, 2008 Feb.
Article
in English
| MEDLINE
| ID: mdl-18190471
ABSTRACT
A case of Philadelphia chromosome positive chronic myeloid leukaemia (CML) with the longest survival ever reported in the medical literature is presented. The duration of the chronic phase was 29 years, the overall survival being 31 years. The clinical course, when challenged with imatinib in the later stages of the disease, was at variance with what is to be expected from the experience in similar situations. Lifelong myelosuppression resulted that interfered with further therapy and contributed to the demise of the patient from sepsis three years later. Caution is suggested with the use of imatinib in fibrotic CML with a low platelet count.
Subject(s)
Blast Crisis/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Piperazines/adverse effects , Primary Myelofibrosis/drug therapy , Protein Kinase Inhibitors/adverse effects , Pyrimidines/adverse effects , Adult , Antineoplastic Agents/therapeutic use , Benzamides , Busulfan/therapeutic use , Fatal Outcome , Humans , Imatinib Mesylate , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/physiopathology , Male , Primary Myelofibrosis/etiology , Survivors , Thrombocytopenia/chemically induced
2.
Am J Hematol
; 82(9): 860, 2007 Sep.
Article
in English
| MEDLINE
| ID: mdl-17616971
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Adult , Alopecia Areata/diagnosis , Fatal Outcome , Hematopoietic Stem Cell Transplantation , Humans , Male , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications
3.
Br J Haematol
; 111(2): 385, 2000 Nov.
Article
in English
| MEDLINE
| ID: mdl-11122075
4.
Br J Haematol
; 110(4): 1012-3, 2000 Sep.
Article
in English
| MEDLINE
| ID: mdl-11202910
Subject(s)
Chickenpox/complications , Herpesvirus 3, Human , IgA Vasculitis/therapy , IgA Vasculitis/virology , Plasma Exchange , Protein S Deficiency/virology , Anticoagulants/therapeutic use , Chickenpox/therapy , Child , Combined Modality Therapy , Cryoglobulins/therapeutic use , Factor V , Heparin/therapeutic use , Humans , IgA Vasculitis/genetics , Male , Prothrombin/genetics
5.
Postgrad Med J
; 73(861): 435-7, 1997 Jul.
Article
in English
| MEDLINE
| ID: mdl-9338035
6.
Lancet
; 348(9020): 129, 1996 Jul 13.
Article
in English
| MEDLINE
| ID: mdl-8676694