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1.
Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots.
Butenko, I G; Gladtchenko, S V; Galushko, S V.
Agents Actions ; 39 Spec No: C49-51, 1993.
Article in English | MEDLINE | ID: mdl-8273583

ABSTRACT

Anti-inflammatory activity of baicalein (5,6,7-trioxyflavone-7-O-beta-D-glucuronide) was greater in the chronic inflammation model (rat adjuvant arthritis, ED50 = 120.6 mg/kg) than observed in the rat carrageenan-induced paw edema, ED50 > or = 200.0 mg/kg. A comparative study of the 5-lipoxygenase (5-LO) inhibitory activity of baicalein, BW 755 C, and hydroxamic acid arachidonate on leukotriene C4 (LTC4) biosynthesis by rat resident peritoneal macrophages stimulated with calcium ionophore (A 23186) showed that these drugs significantly inhibited LTC4 production, IC50: 9.5, 41.8, and 2.8 microM, respectively. This finding suggests that inhibition of the 5-LO pathway of arachidonic acid metabolism may be one of the mechanisms of baicalein's anti-inflammatory activity.


Subject(s)
Arthritis, Experimental/drug therapy , Flavanones , Flavonoids/pharmacology , Inflammation/drug therapy , Leukotriene C4/antagonists & inhibitors , Lipoxygenase Inhibitors , 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine/pharmacology , 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine/therapeutic use , Animals , Arachidonic Acids/pharmacology , Carrageenan/toxicity , Diclofenac/pharmacology , Edema/chemically induced , Edema/drug therapy , Flavonoids/therapeutic use , Hydroxamic Acids/pharmacology , Macrophages, Peritoneal/drug effects , Macrophages, Peritoneal/metabolism , Male , Rats , Rats, Wistar
2.
[Sources of calcium ions participating in the activation of the contraction of smooth muscles of the basilar artery under the action of serotonin]. / Issledovanie istochnikov ionov kal'tsiia, uchastvuiushchikh v aktivatsii sokrashcheniia gladkikh myschts osnovoi arterii pri deistvii serotonina.
Gokina, N I; Butenko, I G; Gurkovskaia, A V; Shuba, M F.
Fiziol Zh (1978) ; 34(5): 74-9, 1988.
Article in Russian | MEDLINE | ID: mdl-3203779

Subject(s)
Calcium/physiology , Cerebral Arteries/physiology , Muscle, Smooth, Vascular/physiology , Serotonin/physiology , Animals , Cattle , Muscle Contraction
3.
[Action of serotonin on the electrogenesis and contraction of the smooth muscles of the basilar artery]. / Deistvie serotonina na élektrogenez i sokrashchenie gladkikh myshts osnovni arterii.
Gokina, N I; Gurkovskaia, A V; Butenko, I G; Shuba, M F.
Fiziol Zh (1978) ; 33(4): 48-53, 1987.
Article in Russian | MEDLINE | ID: mdl-3622813

Subject(s)
Muscle Contraction/drug effects , Muscle, Smooth, Vascular/drug effects , Serotonin/pharmacology , Action Potentials/drug effects , Animals , Basilar Artery/drug effects , Basilar Artery/physiology , Cattle , Dose-Response Relationship, Drug , In Vitro Techniques , Membrane Potentials/drug effects , Muscle, Smooth, Vascular/physiology
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