ABSTRACT
In 62 children with gastroesophageal reflux disease (GERD) and 32 with gastroduodenitis (DG) aged 9-17 years, the peculiarities of metabolism of collagen were studied. High levels of fractions of sialic acids were set, that was associated with the protein fructose, fractions of hydroxyproline in children with GERD compared with the patients with DG, which testify to the process of degradation of collagen and may be one of the factors contributing to the local inflammation of the esophagus and gastroduodenal zone of the digestive tract. The prevalence of Helicobacter pylori, as well as violations of diet, play an important role in maintaining the inflammatory process.
Subject(s)
Collagen/metabolism , Gastroesophageal Reflux/etiology , Gastroesophageal Reflux/metabolism , Helicobacter Infections/etiology , Helicobacter Infections/metabolism , Adolescent , Antibodies, Bacterial/blood , Biopolymers/metabolism , Case-Control Studies , Child , Endoscopy, Digestive System , Feeding Behavior , Female , Gastric Juice/chemistry , Gastroesophageal Reflux/complications , Gastroesophageal Reflux/microbiology , Helicobacter Infections/complications , Helicobacter Infections/microbiology , Helicobacter pylori/immunology , Helicobacter pylori/isolation & purification , Humans , Male , Sialic Acids/metabolismABSTRACT
UNLABELLED: The aim of this work is to study the level of some hormones and their role in the pathogenesis of gastroesophagal reflux disease (GERD) in children. MATERIALS AND METHODS: 40 children with GERD at the age 9 till 17 years of them 17 boys (42.5%) and 23 girls (57.5%) were examined. Content of somatostatin, gastrin, insulin, cortisol in the blood was studied by immunofermental method. Motor function of the sthomach was studied using the apparatus EGC-4M. RESULTS: The investigations which were performed revealed the fact that children with GERD have different concentration of somatostatin and gastrin depending on their age. In disturbances of interrelations of somatostatin and gastrin impairment of the stomach motility occurs. High level of insulin and cortisol is found in children with GERD. High level of insulin indicates of stimulation of protective and adaptative mechanisms. High level of cortisol intensifies catabolic processes, leads to disturbances of dynamic equilibration of aggressive-protective factors in the gastroduodenal zone. CONCLUSION: The results of our study revealed vital role of hormonal factors in the pathogenesis of GERD in children.
Subject(s)
Gastric Emptying , Gastroesophageal Reflux/blood , Gastroesophageal Reflux/physiopathology , Hormones/blood , Stomach/physiopathology , Adolescent , Age Factors , Child , Female , Humans , MaleABSTRACT
We have studied the peculiarities of the heart lesions in 177 children with Gastroesophageal Reflux Disease (GERD), among them 73 children had accompanying residual organic lesion of the central nervous system (ROL CNS). While examining the patients general clinical findings, the results of the complex electrophysiological and endoscopic investigations were used. The disturbance of the heart rhythm and the conduction of the heart were revealed in most children with GERD and with accompanying ROL CNS. It was revealed that the role of disbalance of vegetative innervation is of great importance in the functional lesion of the heart.
