[The histophysiological characteristics of ovarian development with an altered level of thymic peptides at infancy in mice]. / Gistofiziologicheskie osobennosti razvitiia iaichnika v usloviiakh izmeneniia soderzhaniia timicheskikh peptidov v infantil'nom vozraste u myshei.

Thymic peptides effect on the female gonad development was studied: consequences of these substances dysbalance in infancy (T-activine administration of 0.1 microgram/g of body weight in dose since 8 to 21 postnatal day) was analysed. Morphofunctional diagnostics of the ovarian state is based on the spontaneous organism reaction to the drug administration (to 21-days-old animals) and on the distant consequences of its activity (in 1-, 2-, 3-months female animals). Thymic peptides dysbalance in infancy promotes only transitory disorders of the ovarian histophysiology, expressing in transitory inhibition of the follicle genesis with the simultaneous atretic process activation, which results in puberty delay with the following complete restoration of reproductive function. Taking into account that in the early neonatal period gonad reacts to T-activine administration with the development of strong ovarian pathology, the results obtain allow to conclude that the reactivity to thymic peptides content oscillations reduces so as the significance of the factors cited in the ovarian morphogenesis regulation in proportion with the animals' maturity.

[The role of thymic peptides in regulating ovarian morphogenesis]. / Rol' timicheskikh peptidov v reguliatsii ovarial'nogo morfogeneza.

Morphological analysis of the postnatal ovary development in mice treated with diverse T-activine doses during first 48 hours has shown that change of the thymic peptides content during neonatal period (single injection of the drug in doze 1,0-25,0 micrograms/l g body weight) results in negative ovariotropic effect, manifestations of which are doze-depending. In the case of administration of 5,0, 10,0, 25,0 micrograms/l kg of T-activine ovaritropic effect is limited with transitory disturbances of follicle genesis and therefore, with the delay of pubescence with the following (by the 10th month) reproductive function rehabilitation. After administration of T-activine 1 micrograms/l g in doze ovary dysgenesis with the regular reproductive disturbances was observed. Morphological and functional manifestations of the ovarian pathology in the case under discussion were similar with that of genetically non-thymus and neonatally thymus-ectomized animals, which, probably, may be considered to be the proof of the suggestion that thymic peptides dysbalanse on the early ontogenesis stages plays an important role in pathogenesis of the ovarian dysfunction in non-thymus animals.