Optomechanical nonlinearity in dual-nanoweb structure suspended inside capillary fiber.

A novel kind of nanostructured optical fiber, displaying an extremely high and optically broadband optomechanical nonlinearity, is presented. It comprises two closely spaced ultrathin glass membranes (webs) suspended in air and attached to the inner walls of a glass fiber capillary. Light guided in this dual-web structure can exert attractive or repulsive pressure on the webs, causing them to be pushed together or pulled apart. The elastic deflection of the webs is, in turn, coupled to the electromagnetic field distribution and results in a change in the effective refractive index within the fiber. Employing a pump-probe technique in an interferometric setup, optomechanically induced refractive index changes more than 10^{4} times larger than the Kerr effect are detected. Theoretical estimates of the optomechanical nonlinearity agree well with the experimental results. The dual-web fiber combines the sensitivity of a microoptomechanical device with the versatility of an optical fiber and could trigger new developments in the fields of nonlinear optics, optical metrology, and sensing.

Optomechanical self-channeling of light in a suspended planar dual-nanoweb waveguide.

It is shown that optomechanical forces can cause nonlinear self-channeling of light in a planar dual-slab waveguide. A system of two parallel silica nanowebs, spaced ~100 nm and supported inside a fiber capillary, is studied theoretically and an iterative scheme developed to analyze its nonlinear optomechanical properties. Steady-state field distributions and mechanical deformation profiles are obtained, demonstrating that self-channeling is possible in realistic structures at launched powers as low as a few mW. The differential optical nonlinearity of the self-channeled mode can be as much as 10×10(6) times higher than the corresponding electronic Kerr nonlinearity. It is also intrinsically broadband, does not utilize resonant effects, can be viewed as a consequence of the extreme nonlocality of the mechanical response, and in fact is a notable example of a so-called accessible soliton.

Validation of two in vitro test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts.

In order to establish alternatives to the frequently used uterotropic assay with mice, defined estrogen-sensitive cell lines (MCF-7 cells and LeC-9 cells) were used to determine the estrogenic activities of purified compounds of vegetable origin (myco- and phytoestrogens) and zearalenone-contaminated forage cereals (wheat, barley and oats). In MCF-7 cells, a human breast cancer cell line, the induction of an estrogen-specific exoprotein served as a parameter of estrogenic activities. LeC-9 cells represent a genetically transformed cell clone derived from mouse L-cells. Here, hormone-like activities were measured by the expression of the bacterial chloramphenicol acetyltransferase (CAT) gene under the control of an estrogen-responsive element. Toxic effects affecting cell viability were monitored in this system by the expression of a second reporter gene (the bacterial beta-galactosidase gene controlled by the constitutive human beta-actin promoter). Relative estrogenic activities of myco- and phytoestrogens determined with both systems are concomitant, but higher as compared to the uterotropic assay with mice.