Opportunity abandonment: Why are entrepreneurs vulnerable to type I and II errors?

Opportunity actualization is a critical competency attributed to entrepreneurs, which has received widespread attention in the entrepreneurship literature. However, the knowledge of Entrepreneurial Opportunity Abandonment (EOA) decisions is limited. We, therefore, explore the relatively under-studied EOA, analyzing why entrepreneurs commit decision errors, abandon potentially viable opportunities (type I error) or pursue non-opportunity spaces (type II error), and ultimately forsake them later. Through a scoping literature review, we highlight more profound psychological variables that shape entrepreneurial opportunity behavior triggering EOA decisions. We discuss entrepreneurial cognitive limitations in articulating, concretizing, and communicating the opportunity. We argue that varying construal mindsets cause reification fallacies and create perceptual blocks in enunciating an opportunity idea. Further, subjective stakeholder feedback and biased information exchange largely shape EOA decisions, which are mediated through the information processing capacity of entrepreneurs. Finally, we propose four entrepreneurial decision-limiting hypotheses which require an empirical investigation.

Use of Endpoints in Phase III Randomized Controlled Trials for Hematopoietic Stem Cell Transplantation Over the Last 15 Years: A Systematic Review.

This systematic review aimed to evaluate the proportion of primary and secondary endpoints in hematopoietic stem cell transplant (HSCT) phase III randomized clinical trials (RCTs) and analyze their trends in time and study sponsorship status. The Chi-square test and logistic regression analyses were performed using SPSS version 28. A total of 147 HSCT phase III RCTs from 2006 to 2021 reported 197 primary and 600 secondary endpoints. Overall survival (OS, 17 %), progression-free survival (PFS, 15 %), graft versus host disease (GVHD, 8 %), event-free survival (EFS, 8 %), and organ function (8 %) were the most common primary endpoints. GVHD (12.3 %, n = 74), safety/toxicity/adverse events (11.8 %, n = 71), OS (11.5 %, n = 69), PFS (9.3 %, n = 56), and relapse rate (RR; 7.5 %, n = 45) were the most common secondary endpoints during 2006-2021. After 2013, an increase was noted in the use of PFS as a primary endpoint (12 %-18 %, p = 0.196), while the use of OS as a primary endpoint declined (20 %-13 %, p = 0.170). An increase was observed in using the secondary endpoints RR (5 %-10 %, p = 0.047) and NRM (3 %-6 %, p = 0.047). EFS was used more (14 % vs. 4 %, p = 0.012) than ORR (11 % vs. 2 %, p = 0.003) as a primary endpoint in pharmaceutical-compared to non-pharmaceutical-sponsored studies. As secondary endpoints, the use of EFS (4 % vs. 1 %, p = 0.013) and ORR (4 % vs. 1 %, p = 0.028) was higher, whereas that of organ systems/functions (1.5 % vs. 5.5 %, p = 0.022) and GVHD (6.5 % vs. 15 %, p = 0.002) was lower in pharmaceutical-compared to non-pharmaceutical sponsored studies. GVHD-free relapse-free survival was reported as a primary endpoint in 2 % of studies, while only 5 % reported quality of life as a secondary endpoint. We described commonly used endpoints in HSCT phase III RCTs and patterns in their use over time by funding source and study intervention category.

A study on work-family life imbalance among women administrators in UAE higher education institutions.

The study explored the factors causing work-family imbalance among women administrators in higher education institutions in the UAE and how it affects their personal and organizational well-being. The research found that the existing literature doesn't give enough attention to the mismatch between women administrators' work and family goals. Furthermore, it provides little insight into the integration of work-family support systems. The study applied the Spillover theory to explain that women administrators face significant work-family imbalances that adversely impact their personal well-being and organizational effectiveness. The research also used Facilitation theory to examine how work-family support systems could reduce the adverse effects of work-family imbalances. The study surveyed 271 female administrators working in higher education institutions in the UAE. The findings, presented through structural equation modeling, showed that the demanding nature of research, teaching, and administrative work in higher education and women administrators' professional aspirations in socially demanding societies create work-life imbalance and work stress. The study proposed work-family support systems that could moderate the effect of work-family imbalances on work stress.

Outcomes with allogeneic hematopoietic stem cell transplantation in TP53-mutated myelodysplastic syndrome: A systematic review and meta-analysis.

We conducted a systematic review and meta-analysis to evaluate outcomes after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in TP53-mutated myelodysplastic syndromes (MDS). A literature search was performed on PubMed, Cochrane, Embase, and Clinicaltrials.gov. After screening 626 articles, eight studies were included. Data were extracted following the PRISMA guidelines and analyzed using the meta-package by Schwarzer et al. We analyzed 540 patients. The pooled median 3 (1-5) year overall survival was 21% (95% CI 0.08-0.37, I2=91%, n=540). The pooled relapse rate was 58.9% (95% CI 0.38-0.77, I2=93%, n=487) at a median of 1.75 (1-3) years. The pooled 4-year progression- free survival was 34.8% (95% CI 0.15-0.57, I2=72%, n=105). Outcomes of Allo-HSCT for TP53-mutated MDS patients remain poor, with 21% OS at three years; however, Allo-HSCT confers a survival advantage as compared to non-transplant palliative therapies. Our findings suggest the need to explore novel therapeutic agents in prospective clinical trials.

COVID-19 and distribution centres operations: The impacts and countermeasures.

COVID-19 has wreaked havoc on supply chains. This is particularly true for distribution centres as they struggle to bounce back amid the COVID-19 outbreak. While much literature has recently emerged on supply chain disruption, studies pertaining to the impacts of COVID-19 on distribution centres and the countermeasures taken to mitigate such impacts are elusive and mute. Our study fills this important gap in the supply chain literature. This study employs a multiple-case methodology and conducts 40 semi-structured interviews with senior managers/executives from eight distribution centres in the United Arab Emirates. Our results exhibit that COVID-19 is adversely affecting the distribution centres in at least six distinct ways. For instance, distribution centres are encountering limited staff availability, inventory shortage, destabilized supply chains, excessive inventory, limited capacity and surge in demand. Results also demonstrate six corresponding strategies employed by distribution centres to mitigate the impact. For example, distribution centres enhance warehouse automation, increase hands-on inventory, reshoring manufacturing, use scalable processes and an automation retrieval system, and finally employ a picking strategy. Distribution centres can use the findings provided in this study. Particularly, they can learn how COVID-19 affects them and what corresponding strategies they should adopt to stay strong during this pandemic. This study demystifies its contribution to theory and practice alongside limitations and future research directions.

Can entrepreneurial marketing compensate for late market entry? A moderated mediation analysis.

The study tested whether entrepreneurial marketing (EM) can create unique resource advantages for startups and small firms and compensate for late market entry. The authors collected the responses from 509 fast-food restaurants in Kuwait and analyzed the data through structural equation modeling. The evidence supports a direct effect of time-in-market on market share. However, customer-focused market penetration strategies (MPS) mediated the relationship between time-in-market and market share. Further, innovative, culturally influenced customer relationship management (CRM) moderated the impact of time-in-market and MPS on market share, compensating for late market entry. The authors utilize the Resource Advantage (R-A) Theory to inform market entry literature and provide novel solutions to resource-constrained late entrants who can offset the advantages of early market entrants and gain market share through an entrepreneurial marketing approach. It offers a practical approach for implementing entrepreneurial marketing in assisting small firms in seeking market advantages despite late entry and resource limitations. The study's findings have implications for small firms and marketing managers of late-entrant firms, who can leverage innovative MPS and CRM incorporating cultural artifacts to generate behavioral, emotional, and psychological engagement leading to higher market share.

Outcomes with chimeric antigen receptor t-cell therapy in relapsed or refractory acute myeloid leukemia: a systematic review and meta-analysis.

Background: We conducted a systematic review and meta-analysis to evaluate outcomes following chimeric antigen receptor T cell (CAR-T) therapy in relapsed/refractory acute myeloid leukemia (RR-AML). Methods: We performed a literature search on PubMed, Cochrane Library, and Clinicaltrials.gov. After screening 677 manuscripts, 13 studies were included. Data was extracted following PRISMA guidelines. Pooled analysis was done using the meta-package by Schwarzer et al. Proportions with 95% confidence intervals (CI) were computed. Results: We analyzed 57 patients from 10 clinical trials and 3 case reports. The pooled complete and overall response rates were 49.5% (95% CI 0.18-0.81, I2 =65%) and 65.2% (95% CI 0.36-0.91, I2 =57%). The pooled incidence of cytokine release syndrome, immune-effector cell associated neurotoxicity syndrome, and graft-versus-host disease was estimated as 54.4% (95% CI 0.17-0.90, I2 =77%), 3.9% (95% CI 0.00-0.19, I2 =22%), and 1.6% (95%CI 0.00-0.21, I2 =33%), respectively. Conclusion: CAR-T therapy has demonstrated modest efficacy in RR-AML. Major challenges include heterogeneous disease biology, lack of a unique targetable antigen, and immune exhaustion.

Twitter Research Synthesis for Health Promotion: A Bibliometric Analysis.

BACKGROUND: This study enriched our understanding by systematically reviewing knowledge management twitter health (KMTH) articles extracted from Web of Science (WoS) using cartography analysis through VOSviewer-for the last 11 years. METHODS: A total of 798 KMTH articles were found from 2009 to 2019, analyzed based on the most cooccurrence keywords of KMTH articles. RESULTS: Three clusters emerged through cartography analysis; Cluster 1: Twitter as health education and health promotion platform; Cluster 2: Twitter as public health promotion platform and Cluster 3: Twitter as health sentiment platform through big data and machine learning. CONCLUSION: This study opened new avenues for all health care providers to utilize Twitter as a KM platform to promote health care. This is the first bibliometric analysis of KMTH publications according to our best knowledge.

Consequences of top-down knowledge hiding in firms: A pilot study.

While knowledge hiding has been the subject of some research in the management discipline, extant literature is scant on the consequences of top-down knowledge hiding in firms. Therefore, the purpose of this paper is to explore the individual-level consequences of top-down knowledge hiding in firms. Based on an initial pilot study, the preliminary findings unveil three types of individual-level consequences of top-down knowledge such as loss of personal reputation of knowledge seeker, lack of creativity and lack of productivity. This paper discusses its initial contribution to knowledge hiding literature and concludes by discussing its limitations and scope for future research.

Absence of personal relationship in a buyer-supplier relationship: case of buyers and suppliers of logistics services provider in Australia.

While the importance of personal relationships (e.g. friendship) within supply chain relationships is well established, a gap remains on negative aspects associated with an absence of a personal relationship in the buyer-supplier relationship in the supply chain context. Because there is very limited research in this area, a case study method is employed via semi-structured interviews with 24 senior managers from 10 different companies based in Australia engaged in the process of buying and selling logistics services. Results reveal that an absence of a personal relationship between managers of buying and supplying firms in the supply chain leads to reduced trust, non-sharing of important business ideas and sensitive business information, no peer mentoring, delay in resolving conflicts and low employee engagement. The paper concludes by discussing the contribution to practice, research limitations, and future research directions.