[The use of Smecta for the treatment of the basic digestive tract diseases]. / Primenenie smekty dlia lecheniia osnovnykh zabolevanii pishchevaritel'nogo kanala.

The indices for the gastric contents aggression and protection ratio returned to normal in patients with peptic ulcer and preulcerous condition during the treatment with smekta due to a decrease in proteolytic activity and increase in the synthesis of the mucus protective proteins. Monitoring of intragastric pH in the body of the stomach throughout 24 hours in patients with peptic ulcer of duodenal location revealed significant acid-neutralizing effect of smekta. Patients with nonspecific ulcerous colitis enjoyed freedom of side effects as a result of the use of salofalk and derived full therapeutic benefit from this treatment. Under the effect of smekta there occurred suppression of the growth of pathogenic proteolytic flora, improvement of qualitative properties of coli flora and growth of sugar-lytic flora in patients with intestinal dysbiosis. According to the data available, smekta strengthens the mucous barrier by improving the conformation of the mucus structural elements.

[An analysis of the mechanism of the effect of intragastric calcium and magnesium on the release of gastrin and insulin in dogs]. / Analiz mekhanizmu vplyvu intrahastral'noho kal'tsiiu i mahniiu na vyvil'nennia hastrynu ta insulinu u sobak.

The experiments have been carried out on four intact awake dogs to study the influence of intragastric introduction of deionized water, 5 mmol/l of calcium and magnesium chloride solutions in a dose of 3 ml/kg on release of gastrin and insulin into blood. It is stated that during the first 4 min after infusion of deionized water the release of gastrin decreases by 89 +/- 32 conventional units (c.u.), CaCl2 exerts a more pronounced inhibitory effect (168 +/- 36 c.u.), while MgCl2, on the contrary, increases the gastrin release by 398 +/- 92 c.u. Atropin (0.03 mg/kg, subcutaneous injection, 10 min before infusion) absolutely takes away the gastrin-stimulating effect of magnesium, but it has almost no influence on the gastrin-inhibitory effect of calcium. The latter can be taken away by 62% by ornid (5 mg/kg subcutaneously, 20 min before infusion). Preliminary anaesthesia of the stomach mucosa by trymecain or novocain absolutely remove the effect of both calcium and magnesium. Insulin release remained significantly unchanged in any series of experiments.

[The osmotic regulation of gastrin secretion by the isolated rat duodenum]. / Osmoticheskaia reguliatsiia sekretsii gastrina izolirovannoi dvenadtsatiperstnoi kishki krysy.

Activating effect of osmotic irritant agent was suppressed by N- and M-cholinoblocking agents, benzohexonium and pyrenzepine in the rat isolated duodenum. The same was true for phentolamine and not for obsidan. The data obtained suggest that the osmotic regulation of the gastrin secretion is performed through the mechanism of a local intramural reflex with participation of N- and M-cholinoreactive and alpha-adrenoreactive agents.

[Features of gastrin reaction in rats with different susceptibilities to gastric mucosa lesions in immobilization-cold stress]. / Osobennosti reaktsii gastrina u krys s razlichnoi podverzhennost'iu povrezhdeniiam slizistoi zheludka pri immobilizatsionno-kholodovom stresse.

The connection between the character of gastrin and acid reactions and visible morphological changes of gastric mucosa in immobilising-cold stress was studied in the experiments on mongrel rats. It is established that in the rats the fundal gastric mucosa is resistant to the disturbing action of the immobilising-cold stress. The post-stress gastrin contents in the antrum and duodenum mucosa is higher and in the serum lower than in rats with ulceration. The rats with the stress erosions have the intermediate position. The acid factor didn't play the significant role in the ulcerogenesis because its value didn't overstep the limits established in the extradigestive period.

[The gastrin-secreting effects of the salt components of naftusia water]. / Gastrininkretornye éffekty solevykh komponentov vody naftusi.

Intragastric administration of certain salt components of mineral water naftusia in minimal concentrations (1-5 mmol/l) changes intensity and direction of hypergastrinemic reaction in the rats. The effect is determined by the anionic composition of salts rather than by the cationic one and depends on the initial concentration of gastrin in blood.

[Gastroprotective effect of luminal gastrin]. / Gastroprotektivnoe deistvie liuminal'nogo gastrina.

Experiments on mongrel rats have revealed that ulceration of mucous membrane of the stomach achieved by vinculum of pylorus is formed only in 47% of animals. In this case luminal secretion of gastrin in the rats with unaffected mucous membrane was higher, while the serum secretion--lower than in the rats with injured one. A conclusion is made on the gastroprotective effect of serum gastrin.

[The effect of a course of naftusia water intake on the gastroenteropancreatic endocrine system]. / Vliianie kursovogo priema vody naftusiia na gastroénteropankreaticheskuiu éndokrinnuiu sistemu.

Intake of naftusia mineral water influences insulin, glucagon and gastrin secretion measured in patients with chronic acalculous cholecystitis in the following manner: initial low insulin and glucagon, normal gastrin levels rise; initial elevated gastrin and normal glucagon lower at the start of the treatment. The course of naftusia crenotherapy resulted in adaptation to water intake as evidenced by normalization of high gastrin, low glucagon levels in minimal rise of insulin.

[Effect of noradrenaline on ion and water transport through frog gall bladder epithelium]. / Vliianie noradrenalina na perenos ionov i vody cherez épitelii zhelchnogo puzyria liagushki.

In experiments on isolated gallbladders (GB) of frogs it was established that noradrenaline in concentration of 6.10(-9)--3.10(-4) M acting on the organ from the serosalsurface causes firstly a short increase and then -- a prolonged inhibition of the absorption rate of NaCl -- isotonic fluid from the gall bladder cavity. While the concentration of the mediator increases in the inculation medium, its inhibiting effect increases too. Depression, and at high concentration in the medium, full inhibition of the process of fluid absorption is accompanied with distinct decrease of Na--, K--ATPase activity of gall bladder epithelial cells. Mediator in concentration of 3.10(-8) M caused an increase of membrane potential of the epithelial cells, while its increasing in the inculation medium to 3.10(-6) M caused a decrease of the transmembrane potential difference. Under the noradrenaline influence the increase of the osmotic permeability of the gall bladder's wall for the water flow directed from the mucosa to the serosalsurface of the organ took place, and also the decrease of the wall's permeability for the water flow in the opposite direction was seen. It was concluded that the noradrenaline inhibitory action on the process of absorption of NaCl--isotonic fluid from the gall bladder cavity was observed because of the decrease of the Na--K--ATPase activity, and also because of the change of the permeability of epithelium for the passive ion and water transport.