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Suitability of porous silicon microparticles for the long-term delivery of redox-active therapeutics.
Wu, Elizabeth C; Andrew, Jennifer S; Buyanin, Alex; Kinsella, Joseph M; Sailor, Michael J.
Chem Commun (Camb) ; 47(20): 5699-701, 2011 May 28.
Article in English | MEDLINE | ID: mdl-21503283

ABSTRACT

Thermal oxidation of porous Si microparticles provides an inert carrier for the long-term release of the anthracycline drug daunorubicin. Without prior oxidation, porous Si undergoes an undesirable side reaction with this redox active drug.


Subject(s)
Drug Carriers/chemistry , Silicon/chemistry , Antibiotics, Antineoplastic/administration & dosage , Antibiotics, Antineoplastic/toxicity , Cell Line , Daunorubicin/administration & dosage , Daunorubicin/toxicity , Humans , Microscopy, Fluorescence , Nanostructures/chemistry , Oxidation-Reduction , Porosity
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