Subject(s)
Bile Duct Neoplasms/diagnostic imaging , Bile Ducts, Intrahepatic/diagnostic imaging , Cholangiocarcinoma/diagnostic imaging , Common Bile Duct Neoplasms/diagnostic imaging , Endosonography , Adult , Aged , Aged, 80 and over , Common Bile Duct , Endosonography/methods , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Sensitivity and SpecificityABSTRACT
AIM: The aim of this study was to evaluate hemodynamic and anatomic alterations of the splanchnic venous system and the efficiency and safety of color Doppler radial endosonography in the assessment of cirrhotic patients by comparing Child A cirrhotic patients without portal hypertension findings versus a non-cirrhotic group. METHODS: The study was carried out between January 2009 and February 2010; the study population was 38 cirrhotic patients without portal hypertension and 140 control patients. RESULTS: Hepatopedal flow was monophasic in all the control patients; the flow pattern was chaotic and irregular in 8% of the cirrhotic patients; in the cirrhotic patients the portal vein diameter was increased and the flow velocity reduced; no differences in flow volume were observed between the two groups. Splenic vein diameter and flow velocity were normal. In the majority of the Child A cirrhotic patients without portal hypertension, no changes were seen in portal vein diameter or flow volume; in some patients no significant increase portal vein diameter was observed and showed the flow volumes were unchanged. CONCLUSION: Radial Doppler endosonography may be efficient and safe for assessing the splanchnic system.
Subject(s)
Endosonography , Liver Cirrhosis/diagnostic imaging , Portal Vein/diagnostic imaging , Splanchnic Circulation , Ultrasonography, Doppler, Color , Aged , Algorithms , Case-Control Studies , Endosonography/methods , Female , Follow-Up Studies , Hemodynamics , Humans , Hypertension, Portal , Liver Cirrhosis/physiopathology , Male , Middle Aged , Portal Vein/physiopathology , Predictive Value of Tests , Prospective Studies , Reproducibility of Results , Sensitivity and Specificity , Ultrasonography, Doppler, Color/methodsABSTRACT
Hepatotoxicity is a rare complication of paroxetine, a selective serotonin reuptake inhibitor. Regarded as safe in therapeutic use, there have been reports of cases of severe hepatic dysfunction with gross elevations of transaminase levels that may be related to this drug. We report here severe adverse cholestatic and hepatocellular injury in a patient taking paroxetine probably due to an immune-mediated hypersensitivity reaction.
