[Efficacy of the immunomodulating therapy in complex treatment of gastric cancer complicated by acute hemorrhage using radical operations].

The results of radical operative treatment of 10 patients, suffering gastric cancer, complicated by an acute hemorrhage, using immunomodulating therapy, were presented. The immunomodulator application have promoted the natural cells-killers cytological activity raising, the tumoral antigens (AG) elimination, as well as to enhance the neutrophils bactericidal and phagocytic activity, the circulating immune complexes (AG+IgG), (AG+IgM) formation and their deducing from an organism.

[Effect of additional enteral feeding based on soy suspension on burn wound healing].

Early involvement in complex therapy of burn disease an additional enteral feeding based on soy suspension has enhanced host defenses, improved cell and humoral immunity indices, decreased a number of complications (mainly infectious), stimulated regenerative processes taking place in burn wounds thus speeding patients' recovering.

[Role of enteral feeding mixture based on soy in correction of immune status of patients with burn wounds].

The authors have studied the immune status of patients with burn wounds, which had early received to their complex therapy of burn disease an additional enteral feeding based on soy suspension. All populations of immunocompetent cells have been revealed to be activated, especially T-helper lymphocytes taking part in reparative processes, antibody production, synthesis of anti-inflammatory cytokines, thus contributing to regenerative processes taking place in burn wounds, speeding patients' recovering.

[Seasonal fluctuations in the immunological reactivity of frequently ill children]. / Sezonnye kolebaniia immunologicheskoi reaktivnosti u chasto boleiushchikh detei.

We undertook the present study to gain insights into the state of immunologic and biologic reactivity in an inter-relapse period in those children often falling ill with reference to a particular season of the year. As many as 59 children aged 1-7 who were often taken ill were kept under medical supervision. The assessment of the immunological status was performed by I and II level tests, as per the WHO N 3 memorandum (1980) in an inter-relapse period. Both relative and absolute parameters associated with cellular and humoral immunity were studied. The studies made revealed significant fluctuations in the immunity indices with a season of the year in those children often falling ill, the greatest changes recordable in spring, which fact is to be considered in instituting rehabilitative measures.

[The clinico-immunological efficacy of the new drug preparation Erbisol in patients with chronic hepatitis]. / Kliniko-immunologicheskaia éffektivnost' novogo lekarstvennogo preparata "Erbisol" u bol'nykh khronicheskim gepatitom.

This report presents results of clinicoimmunological evaluation of 52 patients with chronic hepatites, receiving treatment with <>. The data obtained suggest high effectiveness of the preparation in the chronic hepatitis patients not only as a hepatoprotective agent but also as an immunomodulating one exerting effect on both the specific and unspecific links of immunity.

[An evaluation of the efficacy of the new Ukrainian preparation Erbisol in patients with chronic hepatitis]. / Otsenka éffektivnosti novogo otechestvennogo preparata "Erbisol" u bol'nykh khronicheskim gepatitom.

A new drug preparation "Erbisol" was studied for its effect in the treatment of chronic hepatitis. There were 52 patients; of these, chronic active hepatitis was diagnosed in ten, persistent hepatitis in 38, cholangiolytic hepatitis in 4 patients. The preparation has a beneficial effect on the clinical course of the disease and makes for the normalization of biochemical and immunological indicators in patients with persistent hepatitis and in those with chronic active hepatitis with mild degree of activity. In patients with cholangiolytic hepatitis "Erbisol" should be used with caution. The studies made allowed for the conclusion to be drawn to the effect that the preparation "Erbisol" is a highly effective hepatoprotective and immunomodulating drug.

[The assessment of the local immune reaction of the mucosa of the large intestine in patients with nonspecific ulcerative colitis]. / Otsenka sostoianiia mestnoi immunnoi reaktsii slizistoi obolochki tolstoi kishki u bol'nykh nespetsificheskim iazvennym kolitom.

The article presents data on the features of local immune reaction in lamina propria of colonic mucosa in patients with severe unspecific ulcerous colitis. Identification of immunocompetent cells with monoclonal antibodies, considered the most effective method to date, was used in the study. Number of immunocompetent cells in lamina propria of colonic mucosa was established to be significantly higher in patients with severe UUC as compared to that of the control group, subpopulations of B-lymphocytes prevailing. Production of all immunoglobulins, especially of IgG, was increased. This evidences sharp activation of local immune reaction and attempt of the body to strengthen both first and second lines of immune protection in colonic mucosa.

[The immunological aspects of the antibacterial therapy of peptic ulcer patients]. / Immunologicheskie aspekty antibakterial'noi terapii bol'nykh iazvennoi bolezn'iu.

Essence and potency of immunological effects produced by some anti-bacterial drugs used in the treatment of peptic ulcer were determined in the course of immunological survey of patients. Trichopol and--to the less extent--furazolidone were established to provide immunocorrective effect and prevent exacerbation better than amoxicillin. The latter, to the contrary, aggravates secondary immune deficiency.

[An evaluation of the efficacy of different methods for identifying peripheral blood T- and B-lymphocytes in patients with nonspecific ulcerative colitis]. / Otsenka éffektivnosti razlichnykh metodov identifikatsii T- i B-limfotsitov perifericheskoi krovi u bol'nykh nespetsificheskim iazvennym kolitom.

Rosette-forming with sheep's erythrocytes (EAC-RF) and monoclonal antibodies (MCA) were used for account of cell populations and subpopulations in patients with ulcerative colitis and Crohn's disease. It was established that MCA technique does increase accuracy of quantitative determination of immunocompetent cells in such patients but on the whole EAC-RF which is at present more accessible method can be considered quite acceptable for estimation of immune reactivity in nonspecific inflammatory diseases of the colon.

[The principles of administering drug and non-drug treatment methods in peptic ulcer]. / Printsipy naznacheniia medikamentoznykh i nemedikamentoznykh metodov lecheniia iazvennoi bolezni.

As the result of the study optimal schemes of the ulcer disease treatment were elaborated. They include microwave resonance therapy, immunomodulatory and antibacterial drugs with regard to localisation, depth and size of the ulcerous lesion, exacerbation rate, degree of secondary immune disorders and seeding of gastric mucosa with Helicobacter pylori. The treatment suggested allows to shorten the terms of ulcer cicatrization, reduces exacerbation rate and ensures clinico-endoscopic remission in most patients with ulcer disease.

[Drug and non-drug immunocorrection in peptic ulcer]. / Medikamentoznaia i nemedikamentoznaia immunokorrektsiia pri iazvennoi bolezni.

Drug immunocorrection and microwave resonance therapy allowed to normalize the immune status in 93% of patients with ulcer disease. This allowed to achieve clinico-endoscopic remission in 82%, reduce scarring time on the average by 6-7 days and to reduce markedly the recurrence frequency.

[Changes in the trace element content of the blood in chronic hepatitis]. / Izmenenie soderzhaniia mikroélementov v krovi pri khronicheskom gepatite.

Trace elements were examined spectrophotometrically in 45 patients with chronic hepatitis (persisting--31; chronic--14). Lead and cadmium showed a significant increase both in the healthy and hepatitis patients. A reduction of zinc and increase of copper was found in patients with chronic hepatitis. Changes in the content of microelements depended on the severity of the disease.

[Differentiated immunocorrective therapy in nonspecific ulcerative colitis]. / Differentsirovannaia immunokorrigiruiushchaia terapiia pri nespetsificheskom iazvennom kolite.

A comparative study of the clinico-immunological efficacy of steroid hormones and thymus drugs in 50 patients with unspecific ulcerative colitis of different activity grades revealed that their efficacy was not similar at different phases of the disease and depended on the activity of the inflammatory process. Corticosteroids were more effective in inflammatory-destructive changes in the mucosa of the large intestine while in mild inflammation with prevalence of ulcerative-reparative processes, immunomodulators (thymalin) are preferred.

[The T- and B-immunity systems in patients with digestive organ diseases and exposure to internal radiation]. / Sostoianie T- i B-sistem immuniteta u bol'nykh s zabolevaniiami organov pishchevareniia i vnutrennim oblucheniem.

Results are reported of an immunological examination of 534 patients with digestive diseases and 130 healthy persons. 282 patients subjected to radiation effects showed a marked and persistent T-lymphocytopenia, B-lymphocytosis, reduction of the content of T-helpers, T-suppressors, dysimmunoglobulinemia characterized by reduction of IgG content and excessive IgA secretion. These changes were observed during the period of exacerbation and remission requiring the use of immunocorrective agents.

[The characteristics of the clinical course of digestive organ diseases in persons subjected to ionizing radiation exposure resulting from the accident at the Chernobyl Atomic Electric Power Station]. / Osobennosti klinicheskogo techeniia zabolevanii organov pishchevareniia u lits, podvergshikhsia vozdeistviiu ioniziruiushchego izlucheniia v rezul'tate avarii na ChAES.

Results of a study of 1905 persons are reported. Of them 1775 showed diseases of the digestive organs. Among them were were 275 who were subjected to the effect of ionizing radiation. In these 275 patients the most frequent pathology were erosive lesions of the gastric and duodenal mucosa, gastroesophageal reflux, esophagitis. There was a dependence of the onset of the disease and stay in the disaster Zone. The disease was accompanied by a stable T-cellular immunodeficiency that exacerbated the course of the disease. It is recommended to include immunocorrectors in the complex therapy of these diseases.