[Carbohydrate metabolism upon disruption of monoaminergic regulatory mechanisms, developing in the early post-resuscitation period]. / Metabolizm uglevodov v usloviiakh narusheniia monoaminergicheskikh reguliatornykh mekhanizmov, razvivshegosiia v rannem postreanimatsionnom periode.

Within the early period after clinical death of various duration, hyperglycemia developed in dogs as a result of increased secretion of catecholamines; the rate of hyperglycemia depended on the severity of postresuscitation impairments of the central nervous system. Content of blood glucose was increased simultaneously with elevation of insulin production. Within 1-2 hrs after administration of dihydroxyphenylalanine the excessive secretion of catecholamines altered adrenoreceptor system sensitivity in Langerhans islands with the subsequent decrease in insulin production. Content of cAMP in brain of resuscitated dogs as compared with controls was increased less drastically.

[Autonomic-effector disorders in the restorative period after circulatory arrest of varying duration]. / Vegetativno-éffektornye narusheniia v vosstanovitel'nom periode posle ostanovki krovoobrashcheniia razlichnoi dlitel'nosti.

The reactivity of the autonomous nervous system (ANS) was analysed pharmacologically with phenylephrine hydrochloride and D-L-Dopa in experiments on dogs who experienced 1-, 5-, and 10-minute clinical death. In changes of the pronounced character of the postresuscitation damages to the central nervous system, the changes of the ANS differed not only in intensity but also in the trend. Reactivity from sympatho- and parasympathetic types changed in the direction of vegetative equilibrium and atypical reactions. The occurrence of the last named on the first day after 5- and 10-minute clinical death were an absolute prognostic criterion of unfavourable outcome of resuscitation. Disorders of the synthetic capacity of the sympathoadrenal system in increase of the period of circulatory arrest were very important in ANS dysfunction.