ABSTRACT
A colloidal solution of iron oxide nanoparticles has been obtained that ensures an increase in the accuracy of diagnostic information from magnetic resonance tomography (MRT) due to the acceleration of proton relaxation in tissues, which improves the contrast of T1- and T2-weighed images. Improved visualization of small vessels in rat brain has been observed after intravenous injection of 0.1 ml solution containing 5.0 mg of contrasting iron nanoparticles. The paramagnetic properties of iron oxide nanoparticles were studied by the method of proton relaxation, and their size was determined by the method of transmission electron microscopy. The toxic properties ofnanoparticles were determined by their effect on cultured HeLa cells (MTT test). It is recommended to use a colloidal solution of superparamagnetic nanoparticles (size, 8.2 nm) for obtaining a pharmaceutical form of the new magnetic-resonance contrast medium Ferotrast.
Subject(s)
Brain/diagnostic imaging , Contrast Media/pharmacokinetics , Ferric Compounds/pharmacokinetics , Magnetic Resonance Imaging/methods , Nanoparticles , Animals , Contrast Media/chemical synthesis , Contrast Media/pharmacology , Ferric Compounds/chemical synthesis , Ferric Compounds/pharmacology , HeLa Cells , Humans , Radiography , RatsABSTRACT
In 250 young and 24 adult albino rats, the organism resistance to a number of negative factors increased from the 14th to 30th day of life whereas the blood cell resistance decreased. Adaptation to moderate physical loads aided to a more intensive increase of the resistance, the effect being more obvious in elder animals in which the blood cell resistance increased as well. The findings revealed a close interrelationship between the organism's functional systems and its resistance.
