ABSTRACT
Changes in clinical and hemodynamic indices, hemostatic system during therapy with plasminogen tissue activator and streptokinase drugs were studied in 49 patients with massive and submassive forms of pulmonary thromboembolism. Conduction of fibrinolytic therapy with plasminogen tissue activator vs streptokinase produced more marked and rapid change in the main hemodynamic parameters which characterized blood recovery in pulmonary artery. A correlation was revealed between the change in hemostatic system after thrombolytic therapy and development of hemorrhagic complications. Preferable introduction of plasminogen tissue activator is shown when thromboemboli locate in the trunk or in both main pulmonary arteries and in the presence of an occlusive lesion in lobular arteries.
Subject(s)
Fibrinolytic Agents/therapeutic use , Pulmonary Embolism/drug therapy , Streptokinase/therapeutic use , Tissue Plasminogen Activator/therapeutic use , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle AgedSubject(s)
Angioplasty, Balloon, Coronary/methods , Myocardial Infarction/complications , Myocardial Infarction/therapy , Thrombolytic Therapy/methods , Ventricular Dysfunction, Left/complications , Ventricular Dysfunction, Left/therapy , Ventricular Dysfunction, Right/therapy , Electrocardiography , Humans , Male , Middle Aged , Myocardial Infarction/diagnosis , Ventricular Dysfunction, Right/complicationsSubject(s)
Heart Ventricles , Myocardial Infarction/diagnosis , Cardiac Catheterization , Cardiac Output, Low/etiology , Diagnosis, Differential , Echocardiography , Electrocardiography , Humans , Hypotension/etiology , Myocardial Infarction/complications , Myocardial Infarction/diagnostic imaging , Radiography, Thoracic , Radionuclide Ventriculography , Shock, Cardiogenic/etiologyABSTRACT
Six healthy volunteers (aged 19-24) were exposed to head-down tilt (at-10 degrees) for 7 days. The study revealed phasic changes of intracardiac circulation and the pump function which were not accompanied by contractility disorders. On the whole, the changes represented a manifestation of cardiovascular adaptation to hemodynamic shifts that are typical of this type of simulated weightlessness. The echocardiographic parameters varied similarly during the head-down tilt test and the joint Soviet-French experiment onboard Salyut-7.