[The use of immunomodulators, antioxidants and hepatoprotectors for the correction of the liver, erythrocites and the immune system disorders in chronic ethanol intoxication]. / Ispol'zovanie immunomoduliatorov, antioksidantov i gepatoprotektorov dlia korrektsii narushenii v pecheni, éritrotsitakh i immunnoi sisteme pri khronicheskoi intoksikatsii étanolom.

The effectiveness of three various combinations of an immunomodulator with an antioxidant and a membrane protector in the correction of metabolic and immune disorders has been studied in the experiment under 60-days ethanol intoxication. The development of such biochemical syndromes of the liver damage as cytolysis, intrahepatic, intracellular cholestasis, toxic liver damage by necrotic type, insufficiency of synthetic processes and inflammatory has been revealed. Oxidative stress development and the activation of lipid peroxidation on the systemic (blood plasma) and local level (erythrocytes) have been established. Suppression of adaptive immunity formation and phagocytic capabilities of neutrophils under the increase in their oxygen-dependent activity has been determined, which indicates the presence and possible progression of the inflammatory process at the systemic level. A disorder of erythrocytes metabolic activity, a decrease in stable metabolites of nitric oxide detected in blood plasma been revealed, indicating its uncompensated consumption, causing vasoconstriction and thrombosis, which can additionally arise due to the established increase in the prothrombin index. Combined use of "Longidasa", "Mexicor", "Essentiale forte N" or "Glutoxim", "Mexidol", "Heptral" was more effective in the correction of immune-metabolic disorders in chronic alcohol intoxication than "Hepon", "Hypoxen" and "Phosphogliv".

[STRUCTURAL AND FUNCTIONAL PROPERTIES OF ERYTHROCYTES WHEN USING VARIOUS METHODS OF MULTICOMPONENT GENERAL ANESTHESIA AT LAPAROSCOPIC HOLETSISTEKTOMY AT PATIENTS WITH CHOLELITHIASIS.]

At patients with the verfied diagnosis have a cholelithiasis, transferred a laparoscopic holetsistektomy against the combined general anesthesia with muscle relaxants and artificial lung ventilation with use ofvarious anesthetics, the intraerythrocyte intensifi- cation of processes of peroxidation of lipids is established, and in a membrane of erythrocytes essential change of the contents and a ratio of the proteins and lipids responsible for structure, stabilization of a membrane and function of erythrocytes is revealed. Application of a sevoflurane, in comparison with propofol and, especially, a halothane, to a lesser extent influences structurally functional properties of erythrocytes that demands profile development ofpharmacological correction of the revealed violations.

[Immunomodulating and antioxidant effects of vitamins A and E during air and immersion cooling]. / Immunomoduliruiushchee i antioksidantnoe deistvie vitaminov A i E pri vozdushnom i immersionnom okhlazhdenii.

An important factor in the immunosuppression development on cooling is the increase in lipid peroxidation rate in the cell membranes. It was found that vitamins A and E possess a high immunomodulating and antioxidant activity under the acute cold-induced stress conditions. Administration of these vitamins is expedient for patients suffered from cooling in air of by immersion.

[Immunomodulating effect of vitamin A and E preparations during deep local cooling]. / Immunomoduliruiushchee deistvie preparatov vitaminov A i E pri glubokom lokal'nom okhlazhdenii.

It was experimentally established for the first time that cell cytokines of lymphatic nodes play an important role in the immunosuppression development in cases of deep local cooling. Vitamins A and E can be used for correcting the cytokine secretion and the immunocyte sensitivity to their action.

[Immunomodulating effects of vitamin K preparations and its potentiation by riboxine in acute cold stress]. / Immunomoduliruiushchee deistvie preparatov vitamina K i ego usilenie riboksinom pri ostrom kholodovom stresse.

The vitamin K preparations phylloquinone, menadione, and vikasol produce an immunomodulant effect under acute cold-induced stress conditions. A combination of phylloquinone, menadione and riboxin provides an effective means of correcting the immunological reactivity and antioxidant state under the conditions of immersion cooling. The immunomodulant effect of naphthoquinones and riboxin is correlated with their antioxidant activty.

[Immunomodulating and antioxidant effects of magnetic and laser irradiation combined with administration of beta-carotene, essentiale, and riboxine during cold stress]. / Immunomoduliruiushchie antioksidantnye éffekty magnitolazernogo oblucheniia, sochetaiushchegosia s vvedeniem beta-karotina, éssentsiale i riboksina, pri kholodovom stresse.

We studied effects of beta-carotine, essentiale and riboxine on immunometabolic effects induced by laser or magnetic laser radiation in intact rats and rats exposed to immersion cold. We found that combination of laser or magnetic laser radiation with administration of beta-carotine or riboxine more effectively corrected antioxidant status and immunological reactivity than radiation alone or in combination with essentiale.

[Development of immunosuppression and its correction with cell membrane stabilizers in burn trauma]. / Razvitie immunosupressii i ee korrektsiia stabilizatorami kletochnykh membran pri ozhogovoi travme.

Degree IIIB burn suppresses the development of an immune response to T-dependent antigen. Following burn, substances having immunosuppressive active and inducing the emergence of suppressive properties in light erythrocytes occur in blood. Essentiale, alpha-tocopherol acetate and lidocaine enhance the development of an immune response to T-dependent antigen in burn injury. The administration of the drugs reduced the immunosuppressive activity of the sera from the burnt animals. Essentiale attenuated the immunosuppressive properties of red blood cells, while alpha-tocopherol acetate and lidocaine abolished them. Essentiale induced the occurrence of immunostimulating properties in heavy red blood cells from the burnt animals while alpha-tocopherol acetate and lidocaine enhanced the resistance of light erythrocytes to the burnt rat serum compounds that induced the emergence of immunosuppressive properties in the animals.

[The extracorporeal immunostimulating effect of terrilytin in staphylococcal infection]. / Ekstrakorporal'nyi immunostimuliruiushchii éffekt terrilitina pri stafilokokkovoi infektsii.

The intravenous injection of terrilytin-treated lymphocytes into rats infected with staphylococci enhances the formation of staphylococcal alpha antitoxin in the animals and the development of immune response to T-dependent antigen, such as sheep red blood cells (SRBC), but produces no effect on the development of immune response induced by T-independent antigen (lipopolysaccharide). Terrilytin-treated lymphocytes induce the release of the factor promoting the development of immune response to staphylococcal antigens and SRBC by spleen cells, incapable of adherence to plastic, but have no influence on the development of immune response to lipopolysaccharide in rats infected with staphylococci. At the same time in such rats spleen cells adhering to plastic take part in the transfer of signals from terrilytin-treated lymphocytes to nonadhering spleen cells of recipients.

[Development of secondary immunodeficiency in acute pancreatitis]. / Razvitie vtorichnogo immunodefitsita pri ostrom pankreatite.

Ligation of the pancreatic duct induces the development of the edematous form of acute pancreatitis (OFAP) which is characterized by sharp inhibition of the immune response to sheep erythrocytes. Contrykal injection intensifies development of the immune response in rats with OFAP and blocks the immunosuppressive activity of the serum protein high-molecular fraction. Injection of aminomethylbenzoic acid does not affect the development of the immune response in rats with OFAP and does not block the immunosuppressive activity of the high-molecular fraction of serum proteins. The difference in the immunomodulating effect of contykal and aminomethylbenzoic acid in OFAP correlates with the different effect of the agents on the activity of proteases and antiproteolytic proteins in blood serum.