[Factors, determining the activity of a new antimicrobial substance from fish oils from various species]. / Faktory, opredeliaiushchie aktivnost' novogo antimikrobnogo preparata iz rybnykh zhirov razlichnoi prirody.

The induction of antimicrobial activity of a new preparation, an aqueous fraction of water-oil emulsion oxidized by air oxygen, was studied. The effect of various factors (the degree of unsaturation of the initial oil and the content of oil oxidation products in obtained preparation) on the antimicrobial activity was determined. The antimicrobial activity of the preparation was induced by oil oxidation. The preparation produced from sardine Sardinops melanostica oil (33.95% of polyunsaturated fatty acids) displayed the highest antimicrobial activity. The antimicrobial activity was shown in water-soluble oil oxidation products.

[(2E)-4-hydroxy-2-nonenal--an active component of a new natural antimicrobial substance]. / (2E)-4-gidroksi-2-nonenal'--aktivnyi komponent novogo prirodnogo antimikrobnogo preparata.

A mixture of water-soluble oxidation products of Sardinops melanosticta sardine oil was found to contain (2E)-4-hydroxy-2-nonenal. This was isolated by column chromatography on silica gel and reversed-phase HPLC. Its structure was elucidated by physicochemical methods. The activity of (2E)-4-hydroxy-2-nonenal against test cultures of Escherichia coli, Staphylococcus aureus, and Bacillus subtilis was about 20% of the total antimicrobial activity of the preparation.