ABSTRACT
Some 13--33,7% old people use non-steroid antiphlogistics. The authors mention undesirable effects, their incidence being higher in advanced age, as well as differences between effects of different non-steroid antiphlogistics.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Aged , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , HumansABSTRACT
BACKGROUND: Recurrent parotitis in children is a relatively frequent disease, the pathogenesis of which has not been cleared yet. OBJECTIVES: The possibility of autoimmune mechanisms participating in the disease development was evaluated. METHODS: 20 sera samples from patients with recurrent parotitis in children were examined. The presence of autoantibodies was tested on cryostat sections of the parotid gland tissue using direct immunofluorescence. RESULTS: In 17 sera the presence of autoantibodies reacting with the cytoplasm of acinar cells and in 8 antibodies reacting with the cytoplasm of ductal cells were found. Mostly they were of IgM class, less frequently the IgG type. Anti-nuclear antibodies were not identified. CONCLUSIONS: With regard to the clinical finding of isolated and mostly unilateral affliction of the parotid gland, the found autoantibodies cannot be considered pathognomic, causing an autoimmune disease. It is assumed that these autoantibodies are produced in response to the primary damage of the salivary gland, the cause of which has not been fully explained so far. (Tab. 1, Fig. 4, Ref. 14.).
Subject(s)
Autoantibodies/analysis , Parotitis/immunology , Adolescent , Child , Child, Preschool , Humans , Infant , Parotid Gland/immunology , RecurrenceABSTRACT
In a great proportion of children loss of hearing originates during the neonatal period. It is assumed that of 1000 neonates some 6 to 16 children suffer from impaired hearing. By early detection of hearing loss during neonatal and infant age by appropriate treatment, rehabilitation and training it is possible to achieve optimal speech development as well as development of mental and somatic abilities and to ensure to these children an adequate role in society. Early detection of impaired hearing based on screening of risk children already during the neonatal period is based on the use a risk registry. At the same time it is important to make parents and paediatricians of the first line of contact familiar with developmental stages of hearing and speech during the first year of life. Risk children must be dispensarized and they must be objected to orientative examination of hearing by reflex audiometry and other screening methods incl. the method of assessment of evoked otoacoustic emission. By systematic screening is is possible to detect suspected loss of hearing in as many as 60% of risk children. To verify the suspect impaired hearing it is necessary to make an objective examination of hearing by a child otolaryngologist.
