Pronóstico de los ancianos ventilados mecánicamente en la UCI / Prognosis of elderly patients subjected to mechanical ventilation in the ICU

Objetivo Analizar el pronóstico de los pacientes ancianos ventilados mecánicamente en la Unidad de Cuidados Intensivos (UCI).Diseño y ámbito Análisis secundario de un estudio observacional prospectivo y multicéntrico llevado a cabo durante un periodo de 2 años en 13 UCI españolas. Pacientes Pacientes adultos que precisaron ventilación mecánica (VM) invasiva durante más de 24 horas. Intervencione Ninguna. Variables de interés Datos demográficos, APACHE II, SOFA, motivo de VM, comorbilidad, situación funcional, reintubación, duración de la VM, traqueotomía, mortalidad en la UCI, mortalidad hospitalaria. Resultados Se incluyeron 1.661 pacientes. De ellos 1.127 (67,9%) eran hombres. Edad: 62,1±16,2 años. APACHE II: 20,3±7,5. SOFA total: 8,4±3,5. Cuatrocientos veintitrés pacientes (25,4%) tenían 75 años o más. Los índices de comorbilidad y capacidad funcional fueron peor en este grupo de pacientes (p<0,001 para ambas variables). La mortalidad en la UCI fue superior en este grupo (33,6%) que en los más jóvenes (25,9%) (p=0,002), al igual que la mortalidad hospitalaria (41,8 vs 31,8%; p<0,0001). No hubo diferencias en cuanto a tiempo de VM, incidencia de traqueotomías o índice de reintubaciones. Por causas de VM solo los pacientes ≥ 75 años ventilados por neumonía, sepsis o trauma presentaron una mortalidad en UCI más alta que los menores de esa edad (46,3 vs 33,1% p=0,006; 55 vs 25,8% p=0,002; 63,6 vs 4,5% p<0,001 respectivamente).Conclusiones Los ancianos (≥ 75 años) tienen una mayor mortalidad en UCI y hospitalaria que los más jóvenes sin diferencias en la duración de la VM. Las diferencias son a expensas de patologías como neumonía, sepsis y trauma (AU)

Objective To analyze the prognosis of mechanically ventilated elderly patients in the Intensive Care Unit (ICU).Design and scope Sub-analysis of a prospective multicenter observational cohort study conducted over a period of two years in 13 medical-surgical ICUs in Spain. Patients Adult patients who required mechanical ventilation (MV) for longer than 24hours.InterventionsNone.Study variables Demographic data, APACHE II, SOFA, reason for MV, comorbidity, functional condition, reintubation, duration of MV, tracheotomy, ICU mortality, in-hospital mortality. Results A total of 1661 patients were recruited. Males accounted for 67.9% (n=1127), with a mean age of 62.1±16.2 years. APACHE II: 20.3±7.5. Total SOFA: 8.4±3.5. Four hundred and twenty-three patients (25.4%) were ≥ 75 years of age. Comorbidity and functional condition rates were poorer in these patients (p<0.001 for both variables). Mortality in the ICU was higher in the elderly patients (33.6%) than in the younger subjects (25.9%) (p=0.002). Also, in-hospital mortality was higher in those ≥ 75 years of age. No differences in duration of MV, prevalence of tracheostomy or reintubation incidence were found. Regarding the indication for MV, only the patient ≥ 75 years of age with pneumonia, sepsis or trauma had a higher in-ICU mortality than the younger patients (46.3% vs 33.1%, p=0.006; 55% vs 25.8%, p=0.002; 63.6% vs 4.5%, p<0,001, respectively). No differences were found referred to other reasons for MV. Conclusion Older patients (≥ 75 years) have significantly higher in-ICU and in-hospital mortality than younger patients without differences in the duration of mechanical ventilation. Differences in mortality were at the expense of pneumonia, sepsis and trauma (AU)

Prognosis of elderly patients subjected to mechanical ventilation in the ICU.

OBJECTIVE: To analyze the prognosis of mechanically ventilated elderly patients in the Intensive Care Unit (ICU). DESIGN AND SCOPE: Sub-analysis of a prospective multicenter observational cohort study conducted over a period of two years in 13 medical-surgical ICUs in Spain. PATIENTS: Adult patients who required mechanical ventilation (MV) for longer than 24 hours. INTERVENTIONS: None. STUDY VARIABLES: Demographic data, APACHE II, SOFA, reason for MV, comorbidity, functional condition, reintubation, duration of MV, tracheotomy, ICU mortality, in-hospital mortality. RESULTS: A total of 1661 patients were recruited. Males accounted for 67.9% (n=1127), with a mean age of 62.1 ± 16.2 years. APACHE II: 20.3 ± 7.5. Total SOFA: 8.4 ± 3.5. Four hundred and twenty-three patients (25.4%) were ≥ 75 years of age. Comorbidity and functional condition rates were poorer in these patients (p<0.001 for both variables). Mortality in the ICU was higher in the elderly patients (33.6%) than in the younger subjects (25.9%) (p=0.002). Also, in-hospital mortality was higher in those ≥ 75 years of age. No differences in duration of MV, prevalence of tracheostomy or reintubation incidence were found. Regarding the indication for MV, only the patient ≥ 75 years of age with pneumonia, sepsis or trauma had a higher in-ICU mortality than the younger patients (46.3% vs 33.1%, p=0.006; 55% vs 25.8%, p=0.002; 63.6% vs 4.5%, p<0,001, respectively). No differences were found referred to other reasons for MV. CONCLUSION: Older patients (≥ 75 years) have significantly higher in-ICU and in-hospital mortality than younger patients without differences in the duration of mechanical ventilation. Differences in mortality were at the expense of pneumonia, sepsis and trauma.

Modelo de probabilidad de ventilación mecánica prolongada / Prolonged mechanical ventilation probability model

Objetivo: Diseñar un modelo de probabilidad de ventilación mecánica prolongada (VMP) con variables clínicas obtenidas durante las primeras 24 horas de su instauración. Diseño: Estudio de cohorte, observacional, prospectivo, multicéntrico. Ámbito: Trece UCI españolas polivalentes. Pacientes: Adultos ventilados durante más de 24 horas. Intervenciones: Ninguna. Variables de interés: APACHE II, SOFA, variables clínicas y demográficas, motivo de VM, comorbilidad y estado funcional. Se construyó un modelo de riesgo multivariante en el que la variable dependiente tenía tres posibles estados: 1.- Muerte precoz. 2.- Retirada precoz de la VM. 3.- VMP. Resultados: Se incluyeron 1.661 pacientes. El 67,9% (n=1.127) fueron hombres. Edad: 62,1±16,2 años. APACHE II: 20,3±7,5. SOFA: 8,4±3,5. Las puntuaciones APACHE II y SOFA fueron mayores en pacientes ventilados > 7 días (p=0,04 y p=0,0001 respectivamente). El fracaso de la ventilación no invasiva (VNI) se asoció a VMP (p=0,005). Se generó un modelo de riesgo multivariante con las siguientes variables: APACHE II, SOFA, fracaso de VNI, ubicación hospitalaria antes del ingreso en UCI y motivo de ventilación mecánica. La exactitud del modelo global (..) (AU)

Objective: To design a probability model for prolonged mechanical ventilation (PMV) using variables obtained during the first 24hours of the start of MV. Design: An observational, prospective, multicenter cohort study. Scope: Thirteen Spanish medical-surgical intensive care units. Patients: Adult patients requiring mechanical ventilation for more than 24hours. Interventions: None. Study variables: APACHE II, SOFA, demographic data, clinical data, reason for mechanical ventilation, comorbidity, and functional condition. A multivariate risk model was constructed. The model contemplated a dependent variable with three possible conditions: 1. Early mortality; 2. Early extubation; and 3. PMV. Results: Of the 1661 included patients, 67.9% (n=1127) were men. Age: 62.1±16.2 years. APACHE II: 20.3±7.5. Total SOFA: 8.4±3.5. The APACHE II and SOFA scores were higher in patients ventilated for 7 or more days (p=0.04 and p=0.0001, respectively). Noninvasive ventilation failure was related to PMV (p=0.005). A multivariate model for the three above exposed outcomes was generated. The overall accuracy of the model in the training and validation sample was 0.763 (95%IC: 0.729-0.804) and 0.751 (95%IC: 0.672-0.816), respectively. The likelihood ratios (LRs) for early extubation, involving a cutoff point of 0.65, in the training sample were LR (+): 2.37 (95%CI: 1.77-3.19) and LR (-): 0.47 (95%CI: 0.41-0.55). The LRs for the early mortality model, for a cutoff point of 0.73, in the training sample, were LR (+): 2.64 (95%CI: 2.01-3.4) and LR (-): 0.39 (95%CI: 0.30-0.51). Conclusions: The proposed model could be a helpful tool in decision making. However, because of its moderate accuracy, it should be considered as a first approach, and the results should be corroborated by further studies involving larger samples and the use of standardized criteria (AU)

[Prolonged mechanical ventilation probability model]. / Modelo de probabilidad de ventilación mecánica prolongada.

OBJECTIVE: To design a probability model for prolonged mechanical ventilation (PMV) using variables obtained during the first 24 hours of the start of MV. DESIGN: An observational, prospective, multicenter cohort study. SCOPE: Thirteen Spanish medical-surgical intensive care units. PATIENTS: Adult patients requiring mechanical ventilation for more than 24 hours. INTERVENTIONS: None. STUDY VARIABLES: APACHE II, SOFA, demographic data, clinical data, reason for mechanical ventilation, comorbidity, and functional condition. A multivariate risk model was constructed. The model contemplated a dependent variable with three possible conditions: 1. Early mortality; 2. Early extubation; and 3. PMV. RESULTS: Of the 1661 included patients, 67.9% (n=1127) were men. Age: 62.1±16.2 years. APACHE II: 20.3±7.5. Total SOFA: 8.4±3.5. The APACHE II and SOFA scores were higher in patients ventilated for 7 or more days (p=0.04 and p=0.0001, respectively). Noninvasive ventilation failure was related to PMV (p=0.005). A multivariate model for the three above exposed outcomes was generated. The overall accuracy of the model in the training and validation sample was 0.763 (95%IC: 0.729-0.804) and 0.751 (95%IC: 0.672-0.816), respectively. The likelihood ratios (LRs) for early extubation, involving a cutoff point of 0.65, in the training sample were LR (+): 2.37 (95%CI: 1.77-3.19) and LR (-): 0.47 (95%CI: 0.41-0.55). The LRs for the early mortality model, for a cutoff point of 0.73, in the training sample, were LR (+): 2.64 (95%CI: 2.01-3.4) and LR (-): 0.39 (95%CI: 0.30-0.51). CONCLUSIONS: The proposed model could be a helpful tool in decision making. However, because of its moderate accuracy, it should be considered as a first approach, and the results should be corroborated by further studies involving larger samples and the use of standardized criteria.

[Prolonged clinical pattern of brain death in patients under barbiturate sedation: usefulness of transcranial Doppler]. / Patrón clínico de muerte cerebral prolongado en paciente bajo sedación barbitúrica: utilidad del Doppler transcraneal.

INTRODUCTION: Throughout the world, is fully accepted that a person is dead when brain death exists. In most situations, neurological criteria permit the diagnosis of brain death, but in some instances, as when high-dose barbiturate therapy has been used, confirmatory testing are required by law. CLINICAL CASE: We report the case of a 17 year-old women who suffered high-dose barbiturate therapy due to post traumatic intracranial hypertension. During the period of the barbiturate infusion and until six days after the suppression of this therapy, neurological exploration and EEG findings seem to confirm brain death, while transcranial Doppler (TCD) study remained normal. CONCLUSIONS: TCD is a fast, simple and accurate confirmatory testing in the determination of brain death and its findings are not affected by high-dose barbiturate therapy. We think that TCD must be present in all hospitals where mechanical ventilation and support of patients are carried out.

Patrón clínico de muerte cerebral prolongado en paciente bajo sedación barbitúrica: utilidad del Doppler transcraneal / Prolonged clinical pattern of brain death in patients under barbiturate sedation: usefulness of transcranial Doppler

INTRODUCCIÓN: La muerte cerebral se define como el cese irreversible de todas las funciones encefálicas, y equivale legal y biológicamente a la muerte del individuo. Aunque la exploración clínica permite establecer este diagnóstico la mayoría de las veces, en algunas situaciones, como cuando se han utilizado barbitúricos a altas dosis, puede ser necesario recurrir a técnicas complementarias. CASO CLÍNICO: Presentamos el caso de una paciente de 17 años en la que se instauró tratamiento barbitúrico a altas dosis como control de hipertensión endocraneal (HEC). Mientras la paciente recibía este tratamiento y también hasta varios días después de suspenderlo, la exploración clínica y el EEG eran compatibles con muerte encefálica, mientras que el estudio Doppler transcraneal descartaba esta posibilidad, pues demostraba que el flujo sanguíneo cerebral era normal. La paciente recuperó la función cerebral, clínica y eléctrica, 6 días después de la suspensión de los barbitúricos, y en la actualidad deambula de manera autónoma. CONCLUSIONES: El Doppler transcraneal es una prueba rápida, sencilla y muy específica en el diagnóstico de la muerte encefálica, y sus resultados no se modifican por la utilización de sustancias depresoras del sistema nervioso central. Por este motivo debería considerarse una técnica complementaria de adquisición obligada en todos los centros hospitalarios que participen en programas de donación de órganos. (AU)