El estado metabólico y su asociación con la actividad ósea en la mujer posmenopáusica / Metabolic status and its association with bone activity in post-menopausal women

Antecedentes y objetivo: En la posmenopausia se presentan alteraciones en el metabolismo de los lípidos, sensibilidad a la insulina e incremento del tejido adiposo visceral, lo que se asocia a un aumento del riesgo cardiometabólico. La osteocalcina (OCN) es una proteína de remodelación ósea, que recientemente se ha observado que participa en la regulación del metabolismo de la glucosa, lípidos y del tejido adiposo. Son limitados los estudios de OCN en la etapa posmenopáusica. El objetivo de este trabajo fue investigar la relación de la concentración de OCN con la obesidad y el síndrome metabólico (SM) en mujeres pre y posmenopáusicas. Métodos: Estudio transversal que incluyó a 261 participantes de 45 a 60 años, quienes fueron evaluadas clínicamente y se les midió glucosa y perfil de lípidos. La OCN sérica y la insulina se determinaron por quimioluminiscencia. Resultados: De las participantes, 128 fueron premenopáusicas y 133 posmenopáusicas; el 33% de las participantes presentaban SM. En las mujeres posmenopáusicas, la concentración de OCN fue superior en comparación a las premenopáusicas (7,2±4,0 vs. 5,5±6,4 ng/mL, p<0,019). La concentración de OCN en la mujer posmenopáusica con SM fue más elevada en comparación al grupo control (8,4±5,1 vs. 6,3±2,8 ng/mL, p=0,003). Conclusión: En la posmenopausia, el déficit de estrógenos y la resistencia a la insulina se asocian a un incremento de la concentración de OCN

Introduction and objective: Changes in lipid metabolism, insulin sensitivity, and visceral adipose tissue increase cardio-metabolic risk. Recent evidence suggests that osteocalcin (OCN) may play a role in metabolism. However, little is known about the OCN in post-menopausal women. The aim of this study was to investigate the relationship between the concentration of OCN with obesity and metabolic syndrome (MS) in pre-and post-menopausal women. Methods: A cross-sectional study was conducted that included 261 participants who were reviewed clinically and underwent laboratory studies, including the determination of serum OCN and insulin by chemiluminescence. Results: Of the participants, 128 were pre-menopausal, 133 post-menopausal, and 33% had MS. OCN concentration was higher in post-menopausal women than in pre-menopausal (7.7±5.7 vs. 5.3 + 2.6 ng/mL, P<.001). OCN levels in post-menopausal women with MS were greater than those without MS (8.4±5.1 vs 6.3±2.8 ng/mL, P.003). Conclusion: Oestrogen deficiency and insulin resistance are associated with increased OCN during the stage of post-menopausal stage

[Evaluation of visceral adipose tissue and lipid level in premenopausal and postmenopausal women's]. / Evaluación del tejido adiposo visceral y de la concentración de lípidos en mujeres pre y posmenopáusicas.

BACKGROUND: Postmenopausal women present weight gain and intensification of obesity, especially visceral adipose tissue (VAT) increases in postmenopausal women. But it is still not clear whether abdominal fat increases during this stage independently of body weight. OBJECTIVE: compare the VAT and lipid profile between postmenopausal and premenopausal Mexican women. METHODS: A case control study in postmenopausal women matched for BMI with premenopausal women. Anthropometric and laboratory measurements as well as body composition analysis were performed. RESULTS: VAT was increased in postmenopausal women in contrast with premenopausal women (114.8 ± 39.5 vs 97.3 ± 29.0, p<0.05). Compared with premenopausal women, postmenopausal women showed higher total cholesterol (231 .6 ± 56.1 vs 206.8 ± 29.5 p <0.05), and LDL-cholesterol levels (145.9 ± 48.3 vs 121.7 ± 34.1, p < 0.05), whereas H DL-cholesterol remained unchanged. CONCLUSION: The results of the present study have demonstrated that Mexican postmenopausal women had a significant increment in visceral adipose tissue and in other metabolic risk factors, independent of the body mass index.