1.
Org Lett
; 18(24): 6448-6451, 2016 12 16.
Article
in English
| MEDLINE
| ID: mdl-27978674
ABSTRACT
A transition-metal-free methodology for the construction of pharmaceutically relevant tertiary aminocyclopropanes is reported. Hydrazonamides, safe and stable carbene precursors, undergo smooth cyclopropanation with vinyl arenes in the presence of a base. The reaction proceeds with stereoselectivity to favor the Z isomer and provides facile access to a variety of substitution patterns through variation of the coupling partners.