ABSTRACT
Los aspectos relacionados con el embarazo y el parto resultan de gran importancia, no solo para los especialistas que atienden a estas mujeres, sino también para las propias gestantes. El día del parto, además del dolor, los calambres y las contracciones, existe un síntoma que no todas identifican. Me refiero al "aro de fuego", una sensación inigualable y sólo se presenta en esa ocasión. Se trata de una sensación de quemazón, de ardor en toda la circunferencia del periné, al dilatarse con la salida de la cabeza del bebé.
Aspects related to pregnancy and childbirth are of great importance, not only for the specialists who care for these women, but also for pregnant women themselves. At delivery, in addition to pain, cramps and contractions, another symptom is present which not all can identify. I refer to "the ring of fire", a unique sensation and only appears on that occasion. It is a burning or stinging sensation throughout the perineum circumference, when dilating with the baby's head crowning.
ABSTRACT
Huntington's disease (HD) is an inherited, neurodegenerative disorder that results from the degeneration of striatal neurons, mainly GABAergic neurons. The study of neurochemical activity has provided reliable markers to explain motor disorders. To treat neurodegenerative diseases, stem cell transplants with bone marrow (BM) have been performed for several decades. In this work we determine the effect of mononuclear bone marrow cell (mBMC) transplantation on the rotational behavior and neurochemical activity in a model of Huntington's disease in rats. Four experimental groups were organized: Group I: Control animals (n = 5); Group II: Lesion with quinolinic acid (QA) in the striatum (n = 5); Group III: Lesion with QA and transplant with mBMC (n = 5); Group IV: Lesion with QA and transplant with culture medium (Dulbecco's modified Eagle's medium (DMEM) injection) (n = 5). The rotational activity induced by D-amphetamine was evaluated and the concentration of the neurotransmitter amino acids (glutamate and GABA) was studied. The striatal cell transplantation decreases the rotations induced by D-amphetamine (p < 0.04, Wilcoxon matched pairs test) and improves the changes produced in the levels of neurotransmitters studied. This work suggests that the loss of GABAergic neurons in the brain of rats lesioned with AQ produces behavioral and neurochemical alterations that can be reversed with the use of bone marrow mononuclear cell transplants.
