ABSTRACT
Nongenetic information implies all the forms of biological information not related to genes and DNA in general. Despite the deep scientific relevance of the concept, we currently lack reliable knowledge about its carriers and origins; hence, we still do not understand its true nature. Given that genes are the targets of nongenetic information, it appears that a parsimonious approach to find the ultimate source of that information is to trace back the sequential steps of the causal chain upstream of the target genes up to the ultimate link as the source of the nongenetic information. From this perspective, I examine seven nongenetically determined phenomena: placement of locus-specific epigenetic marks on DNA and histones, changes in snRNA expression patterns, neural induction of gene expression, site-specific alternative gene splicing, predator-induced morphological changes, and cultural inheritance. Based on the available evidence, I propose a general model of the common neural origin of all these forms of nongenetic information in eumetazoans.
Subject(s)
DNA , Epigenesis, Genetic , HumansABSTRACT
Observational and experimental evidence for the inheritance of acquired traits in animals is slowly, but steadily accumulating. The onset and transmission of acquired traits implies the acquisition and transmission from parents to progeny of new information, which is different from the genetic information contained in DNA. The new non-genetic information most commonly is passed on from parents to the offspring via gamete(s), but how it is precisely transmitted to the successive generations is still unknown. Based on adequate empirical evidence presented herein, a hypothesis is proposed of the inheritance of acquired traits in animals and the flow of the relevant parental information to the offspring.
Subject(s)
Heredity/physiology , Inheritance Patterns/physiology , Animals , Biological Evolution , DNA/genetics , DNA Methylation/physiology , Epigenesis, Genetic/physiology , Gene Expression/physiology , Gene Expression Regulation/physiology , Germ Cells , PhenotypeABSTRACT
Spatially restricted expression of genes by global circulating inducers (hormones, secreted proteins, growth factors, neuromodulators, etc.) was a prerequisite for the evolution of animals. Far from a random occurrence, it is a systematically occurring, certain event, implying that specific information is invested for it to happen. In this minireview, we show for the first time that the expression and regionalization takes place at the level of receptors via a neural mechanism and make an attempt to reconstruct the causal chain from neural signaling to expression of nuclear receptors.
Subject(s)
Receptors, Cytoplasmic and Nuclear/biosynthesis , Alternative Splicing , Animals , Brain/metabolism , Butterflies , Cell Membrane/metabolism , Cell Nucleus/metabolism , Gene Expression Regulation , Gene Expression Regulation, Developmental , Glucocorticoids/metabolism , Humans , Manduca , Mice , Nervous System , Neurons/metabolism , Protein Isoforms , Signal TransductionABSTRACT
Epigenetic inheritance implies the existence of epigenetic information. Great progress has been made in recent years in understanding the role of the changes in epigenetic structures (methylated DNA, histone acetylation/deacetylation and chromatin remodelling) as well as the role of miRNA (MIR) expression patterns in epigenetic processes. However, as of yet, we do not have a satisfactory understanding of the origin of epigenetic information stored in, and conveyed by, these structures. We do not know whether these structures are the ultimate source of the information or whether they are simply media for storing and transmitting epigenetic information for gene expression from upstream sources to the phenotype. Herein an attempt is made to ascertain the ultimate sources of the epigenetic information they contain and transmit by tracing back the causal chain leading to the changes in epigenetic structures.
Subject(s)
Epigenesis, Genetic , MicroRNAs/metabolism , Acetylation , Animals , Cell Proliferation , Chromatin/metabolism , Chromatin Assembly and Disassembly , DNA Methylation , Female , Histones/metabolism , Humans , Male , Mice , Neoplasms/metabolism , Neurons/metabolism , Ovary/metabolism , Phenotype , RatsABSTRACT
Gene recruitment played a critical role in metazoan evolution. Yet, there is no consensus on whether it is an accidental event or a result of an inherent "gene recruiting" mechanism. The prevailing opinion among biologists is that gene recruitment results from random changes in genes or their regulatory regions, but the supporting evidence is poor and controversial. Herein, I present a mechanism in which gene recruitment is a neurally determined event, an adaptive response to changes in environmental conditions. In support of the hypothesis, I present evidence on the manipulative expression of genes in the central nervous system, as well as neurally determined examples of gene recruitment in transgenerational developmental plasticity and in evolution of metazoans.
