Analysis of suspensions and recoveries of official foot and mouth disease free status of WOAH Members between 1996 and 2020.

Foot and mouth disease was the first disease for which, in 1996, the World Organisation for Animal Health (WOAH; founded as OIE) established an official list of disease-free territories, which has helped to facilitate the trade of animals and animal products from those territories. Since that year, there have been a number of suspensions of FMD-free status which have impacted the livestock industry of the territories affected. The objective of this study is to identify factors associated with the time taken to recover FMD-free status after suspension. Historical applications submitted (between 1996 and the first semester of 2020) by WOAH Members for recognition and recovery of FMD-free status were used as the main source of data. Only FMD-free status suspensions caused by outbreaks were considered. Data on the Member's socio-economic characteristics, livestock production systems, FMD outbreak characteristics, and control strategies were targeted for the analysis. The period of time taken to recover FMD-free status was estimated using Kaplan-Meier survival curves. A Cox proportional hazard model was used to identify factors associated with the time taken to recover FMD-free status after suspension. A total of 163 territories were granted official FMD-free status during the study period. The study sample consisted of 45 FMD-free status suspensions. Africa and the Americas accounted for over 50% of FMD-free status suspensions, while over 70% of these occurred in formerly FMD-free territories where vaccination was not practiced. The study noted that implementing a stamping-out or vaccination and remove policy shortened the time to recover FMD-free status, compared with a vaccination and retain policy. Other variables associated with the outcome were the income level of the Member, Veterinary Service capacity, time taken to implement control measures, time taken until the disposal of the last FMD case, whether the territory bordered FMD-infected territories, and time elapsed since FMD freedom. This analysis will contribute toward the understanding of the main determinants affecting the time to recover the FMD free status of WOAH Members and policy processes for FMD control and elimination.

Modeling Intervention Scenarios During Potential Foot-and-Mouth Disease Outbreaks Within U.S. Beef Feedlots.

Foot-and-mouth disease (FMD) is a highly contagious disease of livestock and has severely affected livestock industries during the past two decades in previously FMD-free countries. The disease was eliminated in North America in 1953 but remains a threat for re-introduction. Approximately 44% of the on-feed beef cattle in the U.S. are concentrated in feedlots <32,000 heads, but little information is available on dynamics of FMD in large feedlots. Therefore, there is a need to explore possible management and intervention strategies that might be implemented during potential FMD outbreaks on feedlots. We used a within home-pen stochastic susceptible-latent-infectious-recovered (SLIR) FMD dynamics model nested in a meta-population model of home-pens in a feedlot. The combinatory model was previously developed to simulate foot-and-mouth disease virus (FMDv) transmission within U.S. beef feedlots. We evaluated three intervention strategies initiated on the day of FMD detection: stopping movements of cattle between home-pens and hospital-pen(s) (NH), barrier depopulation combined with NH (NH-BD), and targeted depopulation of at-risk home-pens combined with NH (NH-TD). Depopulation rates investigated ranged from 500 to 4,000 cattle per day. We evaluated the projected effectiveness of interventions by comparing them with the no-intervention FMD dynamics in the feedlot. We modeled a small-size (4,000 cattle), medium-size (12,000 cattle), and large-size (24,000 cattle) feedlots. Implementation of NH delayed the outbreak progression, but it did not prevent infection of the entire feedlot. Implementation of NH-BD resulted in depopulation of 50% of cattle in small- and medium-size feedlots, and 25% in large-size feedlots, but the intervention prevented infection of the entire feedlot in 40% of simulated outbreaks in medium-size feedlots, and in 8% in large-size feedlots. Implementation of NH-TD resulted in depopulation of up to 50% of cattle in small-size feedlots, 75% in medium-size feedlots, and 25% in large-size feedlots, but rarely prevented infection of the entire feedlot. Number of hospital-pens in the feedlot was shown to weakly impact the success of NH-TD. Overall, the results suggest that stopping cattle movements between the home-pens and hospital-pens, without or with barrier or targeted cattle depopulation, would not be highly effective to interrupt FMDv transmission within a feedlot.

A Meta-Population Model of Potential Foot-and-Mouth Disease Transmission, Clinical Manifestation, and Detection Within U.S. Beef Feedlots.

Foot-and-mouth disease (FMD) has not been reported in the U.S. since 1929. Recent outbreaks in previously FMD-free countries raise concerns about potential FMD introductions in the U.S. Mathematical modeling is the only tool for simulating infectious disease outbreaks in non-endemic territories. In the majority of prior studies, FMD virus (FMDv) transmission on-farm was modeled assuming homogenous animal mixing. This assumption is implausible for U.S. beef feedlots which are divided into multiple home-pens without contact between home-pens except fence line with contiguous home-pens and limited mixing in hospital pens. To project FMDv transmission and clinical manifestation in a feedlot, we developed a meta-population stochastic model reflecting the contact structure. Within a home-pen, the dynamics were represented assuming homogenous animal mixing by a modified SLIR (susceptible-latent-infectious-recovered) model with four additional compartments tracing cattle with subclinical or clinical FMD and infectious status. Virus transmission among home-pens occurred via cattle mixing in hospital-pen(s), cowboy pen rider movements between home-pens, airborne, and for contiguous home-pens fence-line and via shared water-troughs. We modeled feedlots with a one-time capacity of 4,000 (small), 12,000 (medium), and 24,000 (large) cattle. Common cattle demographics, feedlot layout, endemic infectious and non-infectious disease occurrence, and production management were reflected. Projected FMD-outbreak duration on a feedlot ranged from 49 to 82 days. Outbreak peak day (with maximum number of FMD clinical cattle) ranged from 24 (small) to 49 (large feedlot). Detection day was 4-12 post-FMD-introduction with projected 28, 9, or 4% of cattle already infected in a small, medium, or large feedlot, respectively. Depletion of susceptible cattle in a feedlot occurred by day 23-51 post-FMD-introduction. Parameter-value sensitivity analyses were performed for model outputs. Detection occurred sooner if there was a higher initial proportion of latent animals in the index home-pen. Shorter outbreaks were associated with a shorter latent period and higher bovine respiratory disease morbidity (impacting the in-hospital-pen cattle mixing occurrence). This first model of potential FMD dynamics on U.S. beef feedlots shows the importance of capturing within-feedlot cattle contact structure for projecting infectious disease dynamics. Our model provides a tool for evaluating FMD outbreak control strategies.

Clinical and infection dynamics of foot-and-mouth disease in beef feedlot cattle: An expert survey.

Parameterizing mathematical models of foot-and-mouth disease virus (FMDv) transmission is challenging due to knowledge gaps on the variable dynamics in susceptible populations. Expert opinion surveys are an approach to gather data on topics where no data have been reported. The objective of this study was to collect-via an expert-opinion survey-key parameter values of the potential FMD natural history and transmissibility in beef feedlot cattle in the U.S. Experts with experience working with FMD in endemic and non-endemic settings were targeted. Parameters surveyed were: duration of infection and disease stages, proportions of animals with specific clinical manifestations, duration and extent of the reduction in feed consumption, and probabilities of severe clinical disease and FMDv transmission. We surveyed the parameter values for infections by strains of different virulence, different infection doses, and routes of transmission. Twenty-seven experts from around the world agreed to participate and 16 (59%) completed the survey. The expert responses to individual questions were resampled via Monte Carlo simulations; to the resulting distributions, candidate theoretical distributions were fitted using the maximum likelihood method and the sought parameter values estimated based on the best-fit distributions. Of the infection stages, the estimates of the expected FMD latent period in beef feedlot ranged from 1.7 to 5.3 days and the infectious period from 5.6 to 10.9 days. Of the disease stages, the estimated incubation period ranged from 2.9 to 6.1 days, subclinical period from 1.2 to 2.8 days, and clinical period from 4.2 to 7.5 days. Probability of developing clinical disease after infection varied from 82% (IQ range 90-70%) with high-virulent to 63% (IQ range 89-60%) with low-virulent strains. Reduction in feed consumption was estimated to last 5 (SD ± 2) days in cattle infected by a low-virulent FMDv strain and 7 (SD ± 2) days for high virulent strains. The study results can be used in combination with experimental and outbreak investigation data to parameterize FMDv-transmission models to evaluate intervention responses during hypothetical FMD epidemics in beef feedlot populations in the U.S.