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1.
Knee Surg Sports Traumatol Arthrosc ; 23(1): 90-6, 2015 Jan.
Article in English | MEDLINE | ID: mdl-24146050

ABSTRACT

PURPOSE: Healing rate of meniscus repair is higher when the suture is associated with anterior cruciate ligament reconstruction. A possible explanation can be a different pattern of release of growth factors between anterior cruciate ligament reconstruction and isolated meniscus surgery. Hypothesis of this study is that the concentrations of bFGF, TGF-ß and platelet-derived growth factor (PDGF) in joint fluid, immediately after single-bundle anterior cruciate ligament reconstruction and arthroscopic partial meniscectomy, can be different. METHODS: Twenty consecutive patients underwent partial medial meniscectomy and twenty consecutive patients underwent single-bundle anterior cruciate ligament reconstruction with hamstring grafts were enrolled in the study. Thirty minutes after the end of the surgical procedure, a sample of joint fluid, as well of venous blood, was collected from all the patients. Concentrations of growth factors were determined by enzyme-linked immunosorbent assay. RESULTS: The peripheral blood concentration of TGF-ß, bFGF and PDGF was comparable between partial meniscectomy and anterior cruciate ligament reconstruction groups. No differences between the two surgical techniques were also found in term of TGF-ß and bFGF joint fluid concentration, whereas joint PDGF concentration of anterior cruciate ligament reconstruction patients was significantly higher than the one found in partial meniscectomy patients. CONCLUSIONS: A significant growth factors release was detected in the knee joint during arthroscopic surgery. PDGF concentration was significantly higher in anterior cruciate ligament reconstructed knee than in the meniscectomy group. PDGF can play an important role enhancing the healing response of meniscus suture and can be one of the biological reasons of the higher meniscal healing rate in anterior cruciate ligament reconstructed knee.


Subject(s)
Anterior Cruciate Ligament Reconstruction , Arthroscopy , Intercellular Signaling Peptides and Proteins/metabolism , Menisci, Tibial/surgery , Synovial Fluid/metabolism , Adult , Enzyme-Linked Immunosorbent Assay , Female , Fibroblast Growth Factor 2/blood , Fibroblast Growth Factor 2/metabolism , Humans , Intercellular Signaling Peptides and Proteins/blood , Male , Middle Aged , Platelet-Derived Growth Factor/metabolism , Transforming Growth Factor beta/blood , Transforming Growth Factor beta/metabolism
2.
Musculoskelet Surg ; 98 Suppl 1: 15-8, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24659201

ABSTRACT

PURPOSE: The purpose of this study is to demonstrate that inferior inclination of the glenosphere is a protecting factor from joint dislocation in reverse total shoulder replacement. The hypothesis is that an average of 10° of inferior inclination of the glenoid component would determine a significant inferior rate of dislocation as compared to neutral inclination. METHODS: A retrospective case (dislocation)-control (stability of the implant) study was performed. Inclusion criteria were the homogeneity of the prosthetic model and availability of pre- and postoperative imaging of the shoulder, including antero-posterior and axillary X-ray views. Glenoid and glenosphere inclination were calculated according to standardized methods. Difference in between the angles determined the inferior tilt. RESULTS: Thirty-three cases fit the inclusion criteria. Glenoid and glenosphere inclination measured, respectively, 74.1° and 83.5°. The average tilt of the glenosphere measured 9.4°. The average tilt in stable patients was 10.2°. Tilt in patients with atraumatic dislocation measured, respectively, -6.9° (superior tilt) and 2.4°, while it was 8.3° for the patient with traumatic instability. The association between the tilt of glenosphere and atraumatic dislocation was significant. CONCLUSIONS: A 10° inferior tilt of the glenoid component in reverse shoulder arthroplasty is associated with a reduced risk of dislocation when compared to neutral tilt.


Subject(s)
Arthroplasty, Replacement , Joint Prosthesis , Shoulder Joint/surgery , Aged , Aged, 80 and over , Arthroplasty, Replacement/methods , Case-Control Studies , Female , Humans , Joint Instability , Male , Middle Aged , Prosthesis Design , Range of Motion, Articular , Retrospective Studies , Shoulder Joint/diagnostic imaging , Treatment Outcome
3.
Knee Surg Sports Traumatol Arthrosc ; 20(11): 2129-38, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22836228

ABSTRACT

PURPOSE: Arthroscopic Bankart repair of anterior shoulder instability is a common practice in orthopedics. The aim of this study was to evaluate pre-operative risks factors associated with recurrent instability and to delineate possible indications for revision surgery. METHODS: A systematic review was performed including the following keywords: arthroscopy, Bankart repair, anterior shoulder instability, recurrence of instability, suture anchors and treatment outcome. Studies eligible for inclusion in the review were clinical trials published in the last 10 years investigating patients with anterior shoulder instability managed by an arthroscopic repair technique with suture anchors. The studies had to report data about recurrence of instability and investigational parameters (risk factors) that influenced the results referred to the rate of recurrence. Twenty-four articles were identified that met the inclusion criteria and underwent further review. Data from these studies were collected, and the risk of treatment failure was statistically recalculated. An estimate of the overall recurrence rate was obtained by pooling data about failure from the trials. RESULTS: The rate of recurrent instability at 10 years of follow-up ranged from 3.4 to 35 %. Epidemiological parameters significantly associated with the recurrence of instability were age below 22 years old, male gender, the number of preoperative dislocations and participation in competitive sports. Surgical parameters significantly associated with recurrence of instability were repair with fewer than three anchors and the use of knotless anchors. The patho-anatomical factors significantly associated with recurrences were substantial associated glenoid or humeral head bone loss and the presence of anterior labroligamentous periosteal sleeve avulsion. CONCLUSIONS: Knowledge of risk factors for post-operative outcomes allows surgeons to provide appropriate preoperative counselling to patients and support more realistic expectations. An accurate analysis of causes of failure should enable the correct revision strategy to be adopted. LEVEL OF EVIDENCE: II.


Subject(s)
Arthroscopy/methods , Joint Instability/surgery , Shoulder Joint/surgery , Age Factors , Humans , Ligaments, Articular/physiopathology , Osteolysis , Recurrence , Risk Factors , Sex Factors , Shoulder Dislocation/complications , Sports , Suture Anchors
4.
Musculoskelet Surg ; 96(1): 9-16, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22205384

ABSTRACT

The aim of this literature review was to report complications associated with arthroscopic rotator cuff repair (RCR). A computerized search of articles published between 200 and 2009 was performed using MEDLINE and PubMed. We included clinical studies (Level 1-4): (a) investigating patients with rotator cuff tears, managed by a completely arthroscopic RCR technique; (b) reported data about complications. Data about arthroscopic-assisted techniques were excluded. Articles that meet criteria inclusion were analytically examined. Complications were classified into general complications and specific complications related to arthroscopic RCR. We found 414 complications in 2,890 patients; most of them were specific complications related to arthroscopic RCR. Re-rupture was the most frequently encountered complication: re-tear rate ranged between 11.4 and 94%. Stiffness and hardware-related complications were observed in 74 and 12 patients, respectively. Eleven less common complications were also reported: 5 neurovascular, 3 septic, 2 thromboembolic events, and 1 anesthesiological complication. This review stated that arthroscopic RCR is a low-risk surgical procedure. Anatomical failure of the repair is the most common complication encountered in the literature.


Subject(s)
Arthroscopy , Intraoperative Complications/etiology , Postoperative Complications/etiology , Rotator Cuff/surgery , Arthroscopy/adverse effects , Arthroscopy/methods , Equipment Failure , Facial Nerve Injuries/etiology , Humans , Intraoperative Complications/epidemiology , Postoperative Complications/epidemiology , Prospective Studies , Recovery of Function , Recurrence , Reflex Sympathetic Dystrophy/epidemiology , Reflex Sympathetic Dystrophy/etiology , Retrospective Studies , Rotator Cuff Injuries , Surgical Wound Infection/epidemiology , Surgical Wound Infection/etiology , Suture Anchors/adverse effects , Thromboembolism/epidemiology , Thromboembolism/etiology
5.
Knee Surg Sports Traumatol Arthrosc ; 20(5): 803-15, 2012 May.
Article in English | MEDLINE | ID: mdl-21964496

ABSTRACT

PURPOSE: The aim of this study was to report orthopedic surgeons' management of choice for difficult clinical scenarios of shoulder pathologies. METHODS: A web questionnaire was developed including four clinical scenarios of shoulder pathologies. Subsequently, opinions were solicited from more than 1,000 members of an international association of surgeons specialized in sports traumatology and knee surgery (ESSKA). RESULTS: The response rate was 40% (412 questionnaires). For scenario 1, first anterior dislocation of the shoulder, the most indicated treatment for 71% of respondents was an arthroscopic Bankart repair (P < 0.001). For scenario 2, shoulder arthritis with concentric erosion and cuff tear, 38% chose a shoulder replacement, while 37% preferred a supraspinatus tendon repair in combination with long head of biceps (LHB) tenodesis or tenotomy. For scenario 3, large tendon tears with 70% fatty infiltration of the infraspinatus tendon and lateral LHB instability, 70% of surgeons considered that, among conservative treatments, hyaluronic acid injection was not an appropriate management. Arthroscopic rotator cuff repair, arthroscopic acromioplasty, and LHB tenotomy gained larger consensus (81, 80, and 79% of respondents, respectively). A double-row technique for rotator cuff repair was preferred to a single-row technique (P = 0.02). Scenario 4, adhesive capsulitis, split the respondents equally, with 51% in favor of a surgical approach and 49% in favor of a conservative approach (N.S.). CONCLUSIONS: On-line questionnaires have the potential to improve knowledge about current trends in clinical practice and can help orthopedic surgeons to develop guidelines. LEVEL OF EVIDENCE: Cross-sectional; Level V (expert opinion).


Subject(s)
Arthritis/complications , Bursitis/surgery , Muscle, Skeletal/injuries , Rotator Cuff Injuries , Shoulder Dislocation/surgery , Shoulder Injuries , Tendon Injuries/surgery , Aged , Arthritis/surgery , Arthroscopy , Female , Health Surveys , Humans , Internet , Male , Middle Aged , Muscle, Skeletal/surgery , Orthopedic Procedures , Orthopedics , Rotator Cuff/surgery , Shoulder Joint/surgery , Surveys and Questionnaires , Young Adult
6.
Minerva Pediatr ; 63(5): 355-61, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21946446

ABSTRACT

AIM: The aim of this paper was to compare the results of treatment of developmental dysplasia of the hip (DDH) with two different devices. METHODS: In 118 DDH, authors employed, in a blinded randomized study, Teuffel-Mignon (TF) and Coxa-Flex (CF) devices. In this study checked 51 hips type IIC; 43 type IID; 15 type IIIA; 9 type IIIB, by Graf classification. RESULTS: Hips Graf's type C were recovered in median 60.09 days, with TM in 50, with CF in 63,45; hips type D in 100 days, with TM in 58,50, with CF in 89.00; hips type IIIA in 103.60 days, with TM in 122, with CF in 94.50; hips type IIIB in 108.66 days, with TM in 121, with CF in 102.50. CONCLUSION: The linear multiple regression model shows a statistically significant associations between outcome and pathological type (P value<0.001), age at diagnosis (P<0.001) and device (P<0.02). The statistical model shows that on average for each day of delay in the diagnosis is needed more than half a day for the patient to recover. The model confirmed that patients with more serious pathologies need more time to recover. Authors think that importance of the treatment of DDH isn't only the type of device employed, but a precise and correct sonographic diagnosis. Very important is starting the treatment as soon as possible, when the infant's bone of hip is more plastic and easy to treat. The authors' opinion is that employing a device instead of another isn't important, fundamental is the choice of the right device derived to a long time clinical experience.


Subject(s)
Hip Dislocation, Congenital/therapy , Splints , Double-Blind Method , Equipment Design , Female , Humans , Infant , Male
7.
Musculoskelet Surg ; 95 Suppl 1: S7-11, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21484442

ABSTRACT

Lateral epicondylitis requires a challenging therapeutic management even for expert surgeons. With the failure of conservative treatment, the physician should consider a surgical choice. The purpose of the surgical procedure is to excise the degenerated tissue of extensor carpi radialis brevis tendon. This article describes the arthroscopic release, performed under direct visualization with a 70° scope; the aim is to encourage the use of this type of lens, versus the traditional 30° one. The patient is positioned in a modified lateral decubitus. After joint distension, a diagnostic arthroscopy of the posterior compartment is performed as first step. Then, an anterior compartment arthroscopic evaluation, a subsequent antero-lateral capsulectomy, and extensor carpi radialis brevis tendon exposition are performed with a 30° view. At this point, the 70° lens is switched and the tendon release is performed under direct control. The 70° lens allows a safer procedure, but requires a dedicated learning curve.


Subject(s)
Arthroscopes , Arthroscopy/methods , Tendinopathy/surgery , Tennis Elbow/surgery , Equipment Design , Humans
8.
J Biol Regul Homeost Agents ; 25(1): 85-91, 2011.
Article in English | MEDLINE | ID: mdl-21382277

ABSTRACT

Various factors may account for the positive association between meniscal repair and anterior cruciate ligament reconstruction, one being the modulation of healing response of meniscal fibrochondrocytes by growth factors released with intra-articular bleeding and fibrin clot formation. Analysis of vascular endothelial growth factor (VEGF) and its receptors, VEGFR1 and VEGFR2, may be useful in the clinical assessment of bone and soft-tissue remodeling. We measured systemic and local levels of VEGF (VEGF165), VEGFR1 and VEGFR2 after either arthroscopic partial meniscectomy (APM) or single-bundle anterior cruciate ligament reconstruction (ACLR) in order to determine the local effect of bone tunnelling and notchplasty on the release of these growth factors. The study population included 40 patients: 20 consecutive patients had undergone ACLR with hamstring grafts and 20 had undergone APM. Thirty minutes after the end of the operation, knee joint fluid samples were collected via the drainage tube and at the same time venous blood samples were drawn. In both sets of samples, VEGF, VEGFR1 and VEGFR2 concentrations were determined by enzyme-linked immunosorbent assay (ELISA). No significant differences in VEGF, VEGFR1 or VEGFR2 concentrations in the venous blood were observed between the two treatment groups. In contrast, VEGF and VEGFR2 levels were significantly higher in the knee joint fluid of the ACLR group; furthermore, VEGF and VEGFR1 were significantly higher in the knee joint fluid than in the venous blood, whereas VEGFR2 was lower in the knee joint fluid than in the venous blood. Local release of VEGF and its angiogenetic receptor VEGFR2, but not the negative regulator VEGFR1, was significantly higher after ACLR than after APM, indicating a better vasculogenic potential for enhanced bone-graft and meniscus healing. These results could suggest that VEGF and VEGFRs could be considered as good biomarkers of tissue healing after knee joint surgery.


Subject(s)
Cartilage, Articular/metabolism , Longitudinal Ligaments/surgery , Synovial Fluid/metabolism , Vascular Endothelial Growth Factor A/metabolism , Vascular Endothelial Growth Factor Receptor-2/metabolism , Adult , Biomarkers/metabolism , Enzyme-Linked Immunosorbent Assay , Female , Humans , Male , Middle Aged , Plastic Surgery Procedures , Vascular Endothelial Growth Factor Receptor-1/metabolism
9.
Injury ; 41(11): 1204-7, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20950805

ABSTRACT

Arthroscopic acromioplasty, one of the most frequent procedures in shoulder surgery, can promote tissue healing process by the release of growth/angiogenic factors from the acromion. Matrix metalloproteinases MMP-2 and MMP-9 are involved in such process. The purpose of this study was to measure MMP-2 and MMP-9 levels in the articular fluid and in the peripheral blood of patients undergoing arthroscopic acromioplasty in order to better understand the local involvement of such factors in the healing process after surgical procedures. Concentrations of MMP-2 and MMP-9 in the subacromial space and peripheral blood collected shortly after surgery were determined by ELISA. MMP-2 and MMP-9 concentrations were measured in the subacromial fluid of 23 patients. In subacromial fluid, the levels between MMP-2 and MMP-9 did not reach statistical significance (127.15±45.56 vs 149.41±53.61 pg/ml, respectively, p>0.05). Peripheral blood levels of MMP-2 (130.75±47.48 pg/ml) were comparable to the subacromial fluid ones (127.15±45.56 pg/ml) whereas MMP-9 level was higher in the subacromial space (149.41±53.61 pg/ml) than in the peripheral blood (67.61±12.62 pg/ml, p<0.001). This work suggests that the measurement of bone specific MMPs (MMP-2 and MMP-9) can be an useful tool to be monitored in parallel with growth factor levels and other bone turnover markers in order to evaluate the bone remodelling and tissue healing processes. This study suggests that the measurement of bone specific MMPs levels, in particular MMP-9, may evaluate the bone remodelling and healing after arthroscopic shoulder acromioplasty.


Subject(s)
Acromioclavicular Joint/surgery , Arthroscopy/methods , Bone Remodeling/physiology , Matrix Metalloproteinase 2/metabolism , Matrix Metalloproteinase 9/metabolism , Wound Healing/physiology , Acromioclavicular Joint/injuries , Acromioclavicular Joint/metabolism , Biomarkers/analysis , Biomarkers/metabolism , Enzyme-Linked Immunosorbent Assay , Female , Humans , Male , Matrix Metalloproteinase 2/analysis , Matrix Metalloproteinase 9/analysis , Middle Aged
10.
Injury ; 41(11): 1117-9, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20934694

ABSTRACT

Adequate restoration of the mechanical alignment, anatomic reduction of the articular surface, and stable fixation allowing early motion of the elbow joint are the primary goals in the treatment of distal humeral fractures. The purpose of our study is the comparison of the effectiveness between distal humeral locking compression plates (LCP) and conventional reconstruction and one third tubular plates. Between January 2008 and January 2009, 11 consecutive patients (4 men and 7 women) with distal humeral fractures were treated with plates in our hospital; eight patients were treated with LCP distal humeral plates and three cases were fixed with a combination of 1/3 tubular plates and reconstruction plates. They were all followed up for 12 months using the functional score of Cassebaum and radiologically with standard X-rays. Good to excellent results were obtained in 6/11 patients with a mean range of motion of 115°. At this small cohort of patients no significant differences between the two fixation methods was identified regarding clinical outcome, complications and function of the affected limb.


Subject(s)
Fracture Fixation, Internal/methods , Humeral Fractures/surgery , Adult , Aged , Bone Plates , Female , Humans , Humeral Fractures/diagnostic imaging , Humeral Fractures/physiopathology , Male , Middle Aged , Preoperative Care , Radiography , Range of Motion, Articular/physiology , Recovery of Function/physiology , Treatment Outcome
11.
J Biol Regul Homeost Agents ; 24(2): 107-14, 2010.
Article in English | MEDLINE | ID: mdl-20487623

ABSTRACT

COX-2 specific inhibitors (coxibs) have become a popular treatment for musculoskeletal disorders given that the incidence of gastrointestinal side effects is lower with these drugs than with traditional non-steroidal anti-inflammatory drugs. The aim of this review is to discuss the results of animal studies investigating the role of coxibs in the healing of soft tissues. MEDLINE was searched (years 2001-2009) for studies analyzing the effect of coxibs on the healing of soft tissues. There are relatively few data in the literature suggesting that coxibs can impair soft tissue healing and the data existing have the limitation of having been generated in animal studies. In fact, the method of administration and the doses used make it difficult to translate these results to the clinical setting. Short-term use of coxibs following lesions to ligaments or tendons remains a prudent choice. Traditional anti-inflammatory drugs are a safer treatment for patients with a high cardiovascular risk. These drugs should, however, be evaluated carefully with regards to gastrointestinal events and their still poorly defined effect on tissue healing.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Anti-Inflammatory Agents/pharmacology , Cyclooxygenase 2 Inhibitors/pharmacology , Wound Healing/drug effects , Animals , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Celecoxib , Cyclooxygenase 2 Inhibitors/adverse effects , Cyclooxygenase 2 Inhibitors/therapeutic use , Humans , Pyrazoles/therapeutic use , Safety , Sulfonamides/therapeutic use , Tendinopathy/drug therapy
12.
Radiol Med ; 114(2): 301-11, 2009 Mar.
Article in English, Italian | MEDLINE | ID: mdl-19194775

ABSTRACT

PURPOSE: This study was done to test a series of magnetic resonance (MR) imaging sequences of the knee after medial unicompartmental arthroplasty. MATERIALS AND METHODS: Four patients who had undergone Oxford III medial unicompartmental arthroplasty underwent 1.5-T MR imaging of the operated knee using coronal sequences: T1-weighted spin-echo (SE), T1-weighted turbo SE (TSE), proton-density (PD)- and T2-weighted TSE, T1-weighted gradient echo (GE), short-tau inversion recovery (STIR), multi echo data image combination (MEDIC), T2*-weighted GE, volumetric interpolated breath-hold examination (VIBE), and dual-echo steady state (DESS). For each sequence, we evaluated the visibility of the anatomical structures of the central pivot, lateral compartment, and anterior compartment using a semiquantitative score (0=total masking; 1=insufficient visibility; 2=sufficient visibility; 3=optimal visibility). The sum of the scores given to each sequence was divided by the maximal sum, obtaining a percentage visibility index. Friedman and sign tests were used for statistical analysis. RESULTS: MR examination time was 30-32 min. No patients reported pain, heat or other local discomfort. The visibility index ranged between 83% and 89% for the first four sequences without significant differences among them, 58% for STIR and 11%-36% for the last five sequences. Significant differences were found between each of the four first sequences and the remaining sequences (p<0.004) and between STIR and the last five sequences (p<0.008). CONCLUSIONS: MR imaging of the knee after medial unicompartmental arthroplasty was not associated with adverse events. An imaging protocol including SE, TSE and STIR sequences could be used to study the knee with unicompartmental arthroplasty.


Subject(s)
Arthroplasty, Replacement, Knee/methods , Image Interpretation, Computer-Assisted/methods , Knee Injuries/surgery , Knee Joint/pathology , Magnetic Resonance Imaging , Aged , Arthroplasty, Replacement, Knee/instrumentation , Echo-Planar Imaging/methods , Female , Humans , Knee Injuries/diagnosis , Male , Middle Aged , Reproducibility of Results , Retrospective Studies , Sensitivity and Specificity , Treatment Outcome
13.
Eur Rev Med Pharmacol Sci ; 12(4): 229-35, 2008.
Article in English | MEDLINE | ID: mdl-18727454

ABSTRACT

Eperisone hydrochloride (4'-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. The aim of this research was to investigate the efficacy of eperisone in patients with acute low back pain and spasticity of spinal muscles. The study design was a randomized, double-blind (double-dummy) study in 160 patients with low back pain and no Rx finding of major spinal diseases, randomly assigned to a treatment with oral eperisone 100 mg three times daily (t.i.d.) or thiocolchicoside 8 mg twice daily (b.i.d.) for 12 consecutive days. Analgesic activity was evaluated by scoring "spontaneous pain" (VAS) and pain on movement and pression (4-digit scale), while muscle relaxant activity of the medication was evaluated by means of the "hand-to-floor" distance and the Lasegue's manoeuvre. All the measures were done at the inclusion day and after 3, 7 and 12 days of treatment. The two medications had comparable analgesic and muscle relaxant efficacy. Sponta-neous pain and pain on movement/pressure were significantly reduced by both treatments. Moreover, both eperisone- and thiocolchicoside-treated patients showed a clinically evident muscle relaxation as proved by a progressive reduction in the "hand-to-floor" distance and increase in the articular excursion (Lasegue's manoeuvre). Only 5% of eperisone-treated patients showed minor gastrointestinal side effects, while the incidence of side effects in the thiocolchicoside group was 21.25%. Moreover, in the thiocolchicoside-treated patients also diarrhoea was present, which reached a moderate intensity in some cases. In conclusions, eperisone represents a valuable and safer alternative to other muscle relaxant agents for treatment of low back pain.


Subject(s)
Low Back Pain/drug therapy , Muscle Relaxants, Central/therapeutic use , Parasympatholytics/therapeutic use , Propiophenones/therapeutic use , Administration, Oral , Adult , Colchicine/adverse effects , Colchicine/analogs & derivatives , Colchicine/therapeutic use , Double-Blind Method , Female , Gastrointestinal Diseases/chemically induced , Humans , Male , Middle Aged , Muscle Relaxants, Central/adverse effects , Pain Measurement , Parasympatholytics/adverse effects , Propiophenones/adverse effects
14.
Ultrasonics ; 42(1-9): 683-7, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15047367

ABSTRACT

GOAL OF THE STUDY: The purpose of this study is to compare the accuracy of sonographic to radiographic measurements of subacromial space, and verify its variations in relation to acromial morphology, age, sex and rotator cuff pathologies. MATERIALS AND METHODS: As a result, we have compared a radiographic examination to sonographic examination, each measuring the subacromial space in 200 random shoulders, with a personal method. The sonographic examination was performed by using a HDI 5000 ultrasound scanner Sono-CT with 7.5 MHz linear array transducer. No stand-off pad was utilized. RESULTS: The statistical analysis of the data derived from the two measurements was not sufficient to conclude that the two techniques are different (p>0.8). They also correspond with the radiographic morphology of the acromion. The size of subacromial space was related to the acromial morphology, female gender, and rotator cuff pathology, however, it was not related to age. DISCUSSION AND CONCLUSIONS: Our results clearly show that sonographic measurements are very close to those obtained by X-ray (p>0.8). The Bland-Altman analysis showed that for all groups, the were small enough to give us confidence that the sonographic technique may be used in place of the radiographic one for clinical purposes. One-way ANOVA showed that sonographic measurements were statistically different among the four groups (p<0.05). The sonography demonstrated precision, accuracy and carefulness in the measurement of the subacromial space.


Subject(s)
Acromion/diagnostic imaging , Shoulder Joint/diagnostic imaging , Adult , Aged , Aged, 80 and over , Analysis of Variance , Female , Humans , Image Processing, Computer-Assisted , Male , Middle Aged , Prospective Studies , Radiography , Ultrasonography
15.
Chir Organi Mov ; 89(2): 143-50, 2004.
Article in English, Spanish | MEDLINE | ID: mdl-15645791

ABSTRACT

PURPOSE: It was the purpose of the study to compare the accuracy of sonographic and radiographic measurement of the subacromial space width, and to verify its variations in relation to the morphology of the acromion, to age, to sex and to pathologies of the rotator cuff. MATERIALS AND METHODS: We compared the radiographic and sonographic examinations for 200 consecutive shoulders. The shoulders examined were divided into 4 groups based on age and pathology of the rotator cuff. RESULTS: We observed that the results obtained in the two different methods of measurement were comparable and statistically significant (p = 0.8). Furthermore, they are corresponded to the morphology of the acromion. Measurement of the subacromial space was in relation to acromial morphology, female sex and pathology of the cuff, but not in relation to age. CONCLUSIONS: Sonography proved to be safe, accurate and useful in measuring the subacromial space, and comparable to what is obtained when radiography is used. We believe that measurement may be the useful completion of the sonographic evaluation of the shoulder. Furthermore, we believe that it may also support the most diffused radiographic measurement and its completion and confirmation. Sonography is certainly useful because of its simplicity of execution, rapidity of use, and measurement of the subacromial space can easily be carried out during routine sonographic evaluation of the shoulder.


Subject(s)
Acromion/diagnostic imaging , Shoulder Pain/diagnostic imaging , Adult , Female , Humans , Male , Middle Aged , Radiography , Ultrasonography
16.
Minerva Pediatr ; 55(2): 143-8, 2003 Apr.
Article in Italian | MEDLINE | ID: mdl-12754458

ABSTRACT

BACKGROUND: The use of ultrasound scanning in the early diagnosis of congenital hip dysplasia in infants within the first six months of life has become part of the routine in preventive medicine examinations. Ultrasound scanning makes it possible to monitor the development of the neonatal dysplasic hip at any moment and it also tells us whether or not it is responding to treatment and, if it is not, to modify the treatment in order to achieve cure. METHODS: The present study considers pathological hips studied echographically over 12 years in order to assess to what extent ultrasound controls during treatment have influenced the choices and modifications of treatment. The study employed different echographic equipment always with 5 or 7.5 MHz linear probes; the evaluation technique employed was that proposed by Graf. Echography evaluation was always proceded by clinical assessment and followed at the end of treatment by X-ray control of the pelvis. RESULTS: Of 17,938 hip cases assessed echographically from 1 January 1989 to 31 December 2000 (59.5% female and 40.5% male, average age 3 months 17 days) 1534 hips were pathological (IIC, IID, IIIA, IIIB); the prevalence of the condition in females and on the left-hand side was confirmed. In 35 cases (2.19%) the orthopaedic treatment approach undertaken at the beginning was changed on the basis of periodic scans. The normalisation of the alpha angle was achieved on average in 51 days of treatment with the harness; with a minimum time of 30 days in IIC type hips in patients below the age of three months and a maximum time of 98 days in hips of type IIIA in patients aged more than 120 days. CONCLUSIONS: The simplicity and ease of use of ultrasound scanning, its cheapness, rapidity, harmlessness and validity not to mention its sensitivity and specificity make it a reliable, safe instrumental examination that is indispensable in planning the treatment of this pathology.


Subject(s)
Hip Dislocation, Congenital/diagnostic imaging , Female , Follow-Up Studies , Hip Dislocation, Congenital/therapy , Humans , Infant , Infant, Newborn , Male , Orthopedic Procedures , Orthotic Devices , Retrospective Studies , Treatment Outcome , Ultrasonography
17.
Arch Orthop Trauma Surg ; 120(5-6): 355-7, 2000.
Article in English | MEDLINE | ID: mdl-10853914

ABSTRACT

We describe two cases of spontaneous fracture at the tibial metaphysis not diagnosed by standard X-ray. In both cases, only magnetic resonance imaging supplied a precise diagnosis and allowed us to follow the evolution of the pathology. Scintigraphy is equally sensitive but unspecific. Osteoporosis was noted in all cases. Hypothetically, similar pathological situations could be present without being diagnosed since they are not always detected by standard X-rays.


Subject(s)
Fractures, Spontaneous/diagnosis , Knee Injuries/diagnosis , Magnetic Resonance Imaging , Tibial Fractures/diagnosis , Aged , Aged, 80 and over , Femoral Fractures/diagnosis , Femoral Fractures/therapy , Follow-Up Studies , Fracture Healing/physiology , Fractures, Spontaneous/therapy , Humans , Male , Recurrence , Sensitivity and Specificity , Tibial Fractures/therapy
19.
Clin Ter ; 141(9): 199-204, 1992 Sep.
Article in Italian | MEDLINE | ID: mdl-1458806

ABSTRACT

In this study the authors evaluated the efficacy and tolerability of a foam of 15% ketoprofen lysine salt versus placebo in patients with articular traumas, pains and strains, distortions etc. All parameters considered were statistically significantly decreased after 7 days of active treatment as compared to placebo. Pain score decreased significantly at pressure (p < 0.001), pain on active movement (p < 0.005), pain on passive movement and pain at rest. Efficacy of the active foam was graded as satisfactory in 81.7% and its tolerability in 92.7% versus 44% and 29% with placebo respectively. Patients reported high acceptability (89%) of the new foam formulation. No systemic or local side effects were observed or reported. The 15% ketoprofen lysine salt foam for topical use can be considered an effective antiinflammatory and analgesic drug for the treatment of minor orthopedic and traumatic disorders, and was found to be perfectly tolerated.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Joints/injuries , Ketoprofen/analogs & derivatives , Lysine/analogs & derivatives , Wounds and Injuries/drug therapy , Administration, Topical , Adolescent , Adult , Drug Tolerance , Female , Humans , Ketoprofen/administration & dosage , Lysine/administration & dosage , Male , Middle Aged , Time Factors
20.
Ital J Orthop Traumatol ; 12(1): 77-83, 1986 Mar.
Article in English | MEDLINE | ID: mdl-3525463

ABSTRACT

Twenty-two patients with severe pain in the hip on weight-bearing after prosthetic replacement were investigated by radiography, arthrography, scintigraphy and ultrasonography to determine the accuracy of these diagnostic methods in detecting loosening of infective or mechanical origin. In two cases, ultrasonography revealed superficial infections that were resolved with antibiotic therapy. Of the remaining 20 cases, 12 involved a deep infection and in 8 the loosening was of mechanical origin. In the deep infections, standard radiography provided a diagnosis in 66% of cases, arthrography in 75% and scintigraphy in 83%, while ultrasonography detected the deep infection in all 12 cases. In the patients with mechanical mobilization, arthrography and ultrasonography were 100% accurate. Since ultrasonography is able to detect discrete or diffuse lesion of the soft tissues around a prosthesis it should be included among the methods used to screen patients with painful hips after prosthetic replacement.


Subject(s)
Hip Prosthesis , Ultrasonography , Aged , Female , Hip Joint/diagnostic imaging , Humans , Male , Prosthesis Failure , Radiography , Radionuclide Imaging , Surgical Wound Infection/diagnosis
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