All-Soft-Tissue Meniscus Allograft Transplantation With Circumferential Suture Tape Augmentation to Mitigate Hoop Stress and Promote Centralization.

Meniscus allograft transplantation (MAT) is a technically challenging procedure. Bone plugs, slot techniques, and all-soft-tissue fixation techniques have been described in the past. Each technique comes with advantages and disadvantages. Native menisci have circumferential collagen fibers to help resist hoop stress during loading cycles. Although hoop stress resistance is a known function of the menisci, its recreation in MAT has only been targeted indirectly through anatomic root placement. The authors describe the use of a high-tensile suture tape (i.e. InternalBrace) to promote centralization by directly mitigating hoop stresses through recreation of peripheral meniscus tensioning in MAT.

Editorial Commentary: Proper Anterior Cruciate Ligament Graft Choice Mitigates Against the Need for Anterolateral Ligament Reconstruction.

It is not coincidence that fervor surrounding anterolateral ligament (ALL) reconstruction increased as double-bundle anterior cruciate ligament reconstruction (ACLR) enthusiasm cooled. But perhaps we shifted our focus too soon, or perhaps we shifted our focus too much. But we must remember that the ACL is primary. Increases in ACL graft diameter by 1 or 2 mm can significantly increase graft strength and decrease revision rate. Biomechanical and clinical evidence suggests that quadriceps tendon ACLR and patellar tendon ACLR demonstrates less pivot shift phenomena than hamstring ACLR. In addition, As biologically active suture tapes become more mainstream, augmented allografts are an increasingly attractive option. Proper ACL graft choice mitigates against the need for ALL reconstruction. Risk factors for anterolateral rotatory instability may include low body mass index and lateral meniscal pathology, in addition to the well-known risks such as age, gender, activity level, and revision cases. Perhaps lateral extra-articular tenodesis should be reserved for high-risk cases.

Trunk and lower extremity long-axis rotation exercise improves forward single leg jump landing neuromuscular control.

BACKGROUND: Anterior cruciate ligament (ACL) injuries often involve sudden single leg loading with directional changes. Trunk and lower extremity (LE) load transfer and muscle power are directly coupled during these movements. The effect of trunk and LE long-axis rotation training on forward single leg drop jump landing and stabilization (FSLDJLS) was studied. METHODS: Using block randomization (gender), 36 (18 men, 18 women) subjects were assigned to experimental (nine, 20 min exercise sessions) and control groups with equal subject number. Ground reaction force (1000 Hz), kinematic (60 Hz) and LE EMG (1000 Hz) data were synchronously collected. Statistical analysis compared pre- and post-test neuromuscular control mean change differences (MCD), and hip flexion-LE peak EMG % maximum volitional isometric contraction (%MVIC) (expressed as decimal equivalents), mean change difference (MCD) relationships. RESULTS: The experimental group had greater landing knee flexion (3.5 ± 3.6° vs. -0.4 ± 3.3°, p = .002) MCD, greater dynamic LE stiffness after landing (0.09 ± 0.14 vs. -0.11 ± 0.14, p = .001) MCD, and increased gluteus maximus (GMAX) (0.20 ± 0.39%MVIC vs. -0.23 ± 0.46%MVIC, p = .006) and gluteus medius (GMED) EMG amplitude (0.22 ± 0.31 vs. -0.07 ± 0.36%MVIC, p = .018) MCD. This group also had decreased GMAX (-166.5 ± 403.6 ms vs. 89.3 ± 196 ms, p = .025), GMED (-75.9 ± 126.8 ms vs. 131.2 ± 207.1 ms, p = .002) and vastus lateralis (-109.1 ± 365 ms vs. 205.5 vs. 510 ms, p = .04) activation duration MCD. More experimental group subjects had increased landing knee flexion MCD (15/18 vs. 8/18, p = .015), increased dynamic LE stiffness MCD (15/18 vs. 2/18, p < .0001) and increased GMAX (15/18 vs. 7/18, p = .006) and GMED (17/18 vs. 10/18, p = .007) EMG amplitude MCD, and reduced GMAX (12/18 vs. 6/18, p = .046), GMED (11/18 vs. 5/18, p = .044), rectus femoris (12/18 vs. 6/18, p = .046), and vastus lateralis (13/18 vs. 7/18, p = .044) EMG activation duration MCD. Only the experimental group displayed significant relationships between landing and peak hip flexion and peak LE EMG amplitude MCD. CONCLUSION: Increased dynamic LE stiffness, increased hip muscle EMG amplitude and decreased hip and knee muscle activation duration MCD in the experimental group suggests improved LE neuromuscular control.

Isolated Patellofemoral Joint Arthroplasty: Can Preoperative Bone Scans Predict Survivorship?

BACKGROUND: Isolated patellofemoral joint arthritis has been identified in 10% of the population presenting with symptomatic knee osteoarthritis. Patient selection is important in order to improve survivorship following PF arthroplasty. The purpose of this study is to compare the use of a preoperative bone scan vs a magnetic resonance imaging (MRI) to identify the patient with isolated PF arthritis. METHODS: This is a retrospective review of 32 patients undergoing isolated PF arthroplasty for PF arthritis using the same implant design. Sixteen consecutive patients received a preoperative bone scan to confirm isolated PF arthritis. These patients were matched by age and gender to patients where an MRI was used to determine isolated PF arthritis. The bone scan cohort contained 13 females and three males with an average age of 48 years and average follow-up of 52 months. There was no significant difference in age, body mass index, follow-up, or preoperative range of motion between the groups. The MRI and bone scan results were reported by a radiologist specializing in orthopedic radiology. RESULTS: Survivorship was 100% in the PF arthroplasty group selected using a preoperative bone scan. Revision surgery with conversion to TKA was required in 5 of 16 patients (31%) when an MRI was used to identify isolated PF arthritis. Revision in all patients in the MRI group was due to progression of knee arthritis in the tibial-femoral joint. There were no cases of implant-related failures. CONCLUSION: Patellofemoral arthroplasty using a modern design implant demonstrated 100% survivorship when a preoperative bone scan was used for patient selection to confirm isolated PF arthritis. In the group where only an MRI was used, there was a 31% failure due to progression of the disease. Based on this study, we would recommend the use of a bone scan as a tool in the selection criteria for patients undergoing PF arthroplasty.

Quadriceps tendon autograft ACL reconstruction has less pivot shift laxity and lower failure rates than hamstring tendon autografts.

PURPOSE: Quadriceps tendon (QT) autograft ACL reconstruction was hypothesized to possess less anterior knee laxity, pivot shift laxity, and lower failure rates than hamstring tendon (HT) autografts. METHODS: Terms "hamstring tendon autograft" and "ACL reconstruction" or "quadriceps tendon autograft" and "ACL reconstruction" were searched in Embase and PubMed. Inclusion criteria required that studies included patients treated for primary ACL injury with reconstruction using either a QT autograft (Group 1) or a HT autograft (Group 2) and instrumented anterior knee laxity assessment. Extracted information included surgical fixation method, graft type, graft thickness or diameter, single vs. double bundle surgical method, publication year, time between the index knee injury and surgery, % women, initial and final subject number, subject age, follow-up length, side-to-side anterior knee laxity difference, Lysholm Score, Subjective IKDC score, anterior knee laxity side-to-side difference grade, ipsilateral pivot shift laxity grade, and failure rate. The Methodological Index for Nonrandomized Studies was used to evaluate study methodological quality. RESULTS: The QT group (Group 1) had 17 studies and the HT group (Group 2) had 61 studies. Overall, Group 2 had greater pivot shift laxity (OR 1.29, 95% CI 1.05-1.59, p = 0.005). Group 2 suspensory femoral fixation had greater pivot shift laxity (OR 1.26, 95% CI 1.01-1.58, p = 0.02) than Group 1 compression femoral fixation. Group 2 compression femoral fixation also had more anterior knee laxity (OR 1.25, 95% CI 1.03-1.52, p = 0.01) than Group 1 compression femoral fixation and higher failure rates based on initial (OR 1.69, 95% CI 1.18-2.4, p = 0.002) and final (OR 1.89, 95% CI 1.32-2.71, p = 0.0003) subject number. Failure rate for HT compression femoral fixation was greater than suspensory femoral fixation based on initial (OR 2.08, 95% CI 1.52-2.84, p < 0.0001) and final (OR 2.26, 95% CI 1.63-3.16, p < 0.0001) subject number. CONCLUSIONS: Overall, QT autografts had less pivot shift laxity and lower failure rates based on final subject number than HT autografts. Compression QT autograft femoral fixation had lower pivot shift laxity than suspensory HT autograft femoral fixation. Compression QT autograft femoral fixation had less anterior knee laxity and lower failure rates than compression HT autograft femoral fixation. Suspensory HT autograft femoral fixation had lower failure rates than compression HT autograft femoral fixation. Greater knee laxity and failure rates may be related to a combination of HT autograft diameter and configuration (tissue quality and dimensions, strands, bundles, and suturing method) variability and fixation mode. LEVEL OF EVIDENCE: Level IV.

Cruciate ligament healing and injury prevention in the age of regenerative medicine and technostress: homeostasis revisited.

PURPOSE: This clinical concepts paper discusses the essential elements of cruciate ligament recuperation, micro-trauma repair, and remodeling. METHODS: Cruciate ligament mechanobiology and tissue heterogeneity, anatomy and vascularity, and synovial membrane and fluid functions are discussed in relationship to deficiency-induced inflammatory responses, nervous and immune system function, recuperation, repair and remodeling, and modern threats to homeostasis. RESULTS: Cruciate ligament surgical procedures do not appreciate the vital linked functions of the central, peripheral, and autonomic nervous systems and immune system function on knee ligament injury recuperation, micro-trauma repair, and remodeling. Enhanced knowledge of these systems could provide innovative ways to decrease primary non-contact knee injury rates and improve outcomes following reconstruction or primary repair. CONCLUSIONS: Restoration of knee joint homeostasis is essential to cruciate ligament recuperation, micro-trauma repair, and remodeling. The nervous and immune systems are intricately involved in this process. Varying combinations of high-intensity training, under-recovery, technostress, and environmental pollutants (including noise) regularly expose many athletically active individuals to factors that abrogate the environment needed for cruciate ligament recuperation, micro-trauma repair, and remodeling. Current sports training practice, lifestyle psychobehaviors, and environmental factors combine to increase both primary non-contact knee injury risk and the nervous and immune system dysregulation that lead to poor sleep, increased anxiety, and poorly regulated hormone and cytokine levels. These factors may create a worst-case scenario leading to poor ligament recuperation, micro-trauma repair, and remodeling. Early recognition and modification of these factors may decrease knee ligament injury rates and improve cruciate ligament repair or reconstruction outcomes. LEVEL OF EVIDENCE: V.

Tissue healing following segmental meniscal allograft transplantation: a pilot study.

PURPOSE: This in vivo histological study using an ovine model evaluated the 90-day healing of unilateral segmental meniscal allograft transplantation. METHODS: Fresh-frozen medial menisci were transplanted to replace the right medial meniscus of six female sheep. Tissue healing was evaluated using semi-quantitative, descriptive methods. Formalin-fixed meniscal, distal femur and proximal tibia tissues were evaluated using Rodeo (cellularity/collagen), Ishida (reparative bonding), Collagen I IHC (collagen I), and Mankin (cartilage organization) scores at the medial femoral condyle (MFC) and medial tibial plateau (MTP). Meniscocapsular evaluations were performed at the: (a) peripheral junction; (b) posterior sector-native meniscus junction; (c) anterior sector-native meniscus junction; (d) posterior horn internal control; and (e) anterior horn internal control. RESULTS: Three animals were euthanized at 39 ± 2.6 days post-surgery because of their knee condition. These animals had moderate Rodeo scores, low Ishida scores, and high Collagen I staining scores indicating moderately high fibrocartilaginous changes, mild or minimal healing and high collagen I content. Cartilage scores were low in the MFC and moderately high in the MTP, indicating mild MFC cartilage changes and moderately high MTP cartilage changes. Full-term (90 day) euthanized animals (n = 3) displayed improving Rodeo scores with mean scores of 3.3 and 3.6 at junctions (B) and (C), respectively. Ishida scores displayed similar improvements at all sectors. Collagen I staining revealed strong (grade 5) levels in all sections, with mean collagen I scores of 5, 5 and 4 for the peripheral (A), posterior (B) and anterior (C) junctions, respectively. Improved healing was observed at each segmental meniscus sector in terminally euthanized animals. CONCLUSIONS: Segmental meniscal allograft transplantation displayed partial healing to remnant meniscal tissue. Further study is needed to better delineate the time needed for complete healing and the joint-loading progression that may enhance it.

Medial meniscus grafting restores normal tibiofemoral contact pressures.

BACKGROUND: Tissue excision in the setting of a meniscal tear has been shown to dramatically increase peak contact stresses in the affected tibiofemoral joint compartment, leading to the development of degenerative changes and osteoarthritis. PURPOSE/HYPOTHESIS: The current in vitro study utilized a porcine model to evaluate the effectiveness of segmental medial meniscal grafting following partial meniscectomy. The study hypothesis was that the procedure would normalize medial tibofemoral joint compartment pressure magnitudes, areas, and locations relative to an intact meniscus. STUDY DESIGN: Controlled laboratory study. METHODS: Using pressure film, medial tibiofemoral joint compartment peak, and mean pressure magnitudes, peak pressure location and peak pressure area were determined using 12 potted, fresh frozen, porcine knee specimens. Data were collected at three different knee flexion angles (90°, 45°, and 0°) for three conditions: intact medial meniscus, following resection of the central third of the medial meniscus, and following segmental medial meniscal grafting. For each condition, the potted femur was positioned horizontally in a bench vise clamp, while a 20 pound (88.96 N) axial compression force was manually applied for a 60 s duration by the primary investigator through the base of the potted tibia using a digital force gauge. RESULTS: Loss of the central 1/3 of the medial meniscus resulted in significant increases in the mean and peak pressures of the medial tibiofemoral joint compartment and decreased peak pressure area. Segmental meniscal grafting of the central third defect closely recreated the contact pressures and loading areas of the native, intact medial meniscus. CONCLUSION: From a static, time zero biomechanical perspective, segmental medial meniscus grafting of a partially meniscectomized knee restored mean pressure, peak pressure, and mean peak contact pressure areas of the medial tibiofemoral joint compartment back to levels observed in the intact medial meniscus at different knee flexion angles. In-vivo analysis under dynamic conditions is necessary to verify the healing efficacy and ability of the healed segmental medial meniscal allograft to provide long-term knee joint homeostasis when confronted with dynamic shear, rotatory, and combined, higher magnitude physiologic loading forces.

Permanent knee sensorimotor system changes following ACL injury and surgery.

The cruciate ligaments are components of the knee capsuloligamentous system providing vital neurosensory and biomechanical function. Since most historical primary ACL repair attempts were unsuccessful, reconstruction has become the preferred surgery. However, an increased understanding of the efficacy of lesion-site scaffolding, innovative suturing methods and materials, and evolving use of biological healing mediators such as platelet-rich plasma and stem cells has prompted reconsideration of what was once believed to be impossible. A growing number of in vivo animal studies and prospective clinical studies are providing increasing support for this intervention. The significance of ACL repair rather than reconstruction is that it more likely preserves the native neurosensory system, entheses, and ACL footprints. Tissue preservation combined with restored biomechanical function increases the likelihood for premorbid neuromuscular control system and dynamic knee stability recovery. This recovery should increase the potential for more patients to safely return to sports at their desired intensity and frequency. This current concepts paper revisits cruciate ligament neurosensory and neurovascular anatomy from the perspective of knee capsuloligamentous system function. Peripheral and central nerve pathways and central cortical representation mapping are also discussed. Surgical restoration of a more physiologically sound knee joint may be essential to solving the osteoarthritis dilemma. Innovative rehabilitative strategies and outcome measurement methodologies using more holistic and clinically relevant measurements that closely link biomechanical and neurosensory characteristics of physiological ACL function are discussed. Greater consideration of task-specific patient physical function and psychobehavioral links should better delineate the true efficacy of all ACL surgical and non-surgical interventions. Level of evidence IV.

Anterior cruciate ligament reconstruction, rehabilitation, and return to play: 2015 update.

Anatomical discoveries and a growing appreciation of the knee as a complex organ are driving innovations in patient care decision-making following anterior cruciate ligament (ACL) injury. Surgeons are increasing their efforts to restore combined mechanical-neurosensory ACL function and placing more consideration on when to reconstruct versus repair native anatomical structures. Surgical options now include primary repair with or without reinforcing the injured ACL with suture-based internal bracing, and growing evidence supports biological augmentation using platelet-rich plasma and mesenchymal stem cells to enhance tissue healing. Physical therapists and athletic trainers are increasing their efforts to facilitate greater athlete cognitive engagement during therapeutic exercise performance to better restore nonimpaired neuromuscular control activation amplitude and timing. Knee brace design and use needs to evolve to better match these innovations and their influence on the rehabilitation plan timetable. There is a growing appreciation for the multifaceted characteristics of the rehabilitation process and how they influence neuromuscular, educational, and psychobehavioral treatment goal achievement. Multiple sources may influence the athlete during the return to sports process and clinical outcome measures need to be refined to better evaluate these influences. This update summarizes contemporary ACL surgical, medical, and rehabilitation interventions and future trends.

In situ comparison of varying composite tibial tunnel interference screws used for ACL soft tissue graft fixation.

PURPOSE: This mechanical study using an in vitro porcine model compared composite interference screw fixation of soft tissue ACL grafts in tibial tunnels. METHODS: Forty-eight porcine profundus tendons and tibiae were divided into four groups of 12 closely matched specimens. Equivalent diameter grafts were assigned to each group. Tibial bone tunnels were drilled to 0.5mm greater than graft diameter. Grafts were fixed in tunnels using one 10 × 35 mm composite interference screw designed by four different manufacturers. Maximal insertion torque and perceived within group mechanical testing outcome predictions were recorded. Constructs were potted and loaded into a six degrees of freedom clamp that placed the servohydraulic device tensile loading vector in direct tunnel alignment. Constructs were pre-loaded to 25 N, pre-conditioned between 0 and 50 N for 10 cycles (0.5 Hz), submaximally tested between 50 and 250 N for 500 cycles (one hertz) and load to failure tested at 20mm/min. RESULTS: Statistically significant differences were not observed between groups for displacement during submaximal cyclic loading, yield load, displacement at yield load, stiffness, ultimate load at failure and displacement at ultimate load. One composite screw group displayed a slightly greater proportion of specimens that required use of more than one screw during insertion. CONCLUSIONS: Under highly controlled conditions groups displayed comparable fixation.

Lower extremity neuromuscular compensations during instrumented single leg hop testing 2-10 years following ACL reconstruction.

BACKGROUND: This study compared lower extremity EMG activation and sagittal plane kinematics of subjects at a minimum of 2 years post-successful ACL reconstruction and rehabilitation during instrumented single leg hop testing. METHODS: Comparisons were made based on subject responses to the following question, "compared to prior to your knee injury how capable are you now in performing sports activities"? Group 1=very capable, Group 2=capable, and Group 3=not capable. In addition to EMG (1000 Hz) and kinematic (60 Hz) data, subjective knee function, internal health locus of control, sports activity characteristics (intensity, frequency) pre-knee injury, and at follow-up were also compared. RESULTS: Group 3 had lower perceived knee function, decreased perceived sports intensity, and more subjects with decreased sports activity intensity by two levels compared to pre-injury values. Perceived function scores, anterior laxity measurements and grades were similar between groups. During single leg hop propulsion and landing Group 1 (very capable) had greater involved lower extremity gluteus maximus and medial hamstring activation amplitudes than Group 3 (not capable). Perceived sports capability was related to better subjective knee function, and higher perceived sports activity intensity. CONCLUSION: Neuromuscular compensations suggesting a hip bias with increased gluteus maximus and medial hamstring activation were identified at the involved lower extremity among most subjects who perceived high perceived sports capability compared to pre-injury status. These compensations may be related to a permanent neurosensory deficit, and its influence on afferent pathway changes that influence CNS sensorimotor re-organization.

ACL double bundle linked cortical-aperture tibial fixation: a technical note.

INTRODUCTION: The purpose of this technical note is to describe the tibial fixation characteristics for an all-inside anatomic anterior cruciate ligament (ACL) reconstruction method that links extra-cortical button suspensory and aperture fixation replicating double bundle soft tissue graft function in single femoral and tibial sockets. MATERIALS AND METHODS: A 55° drill guide aligned guidewires in the ACL footprint center of 8 porcine tibiae (mean apparent bone mineral density = 1.15 g/cm(2)). A Flipcutter created 27 mm sockets and 15 mm guidewire channels. Advancement sutures seated porcine soft tissue graft-PEEK implants to achieve both socket aperture and extra-cortical button suspensory fixation. Potted specimens were loaded into a 6º of freedom clamp with the servohydraulic loading vector in direct socket alignment. Constructs were pre-loaded to 25 N, underwent 10 pre-conditioning cycles (0-50 N, 0.5 Hz), and 500 submaximal loading cycles (50-250 N, 1 Hz) prior to load to failure testing (20 mm/min). Mode of failure was recorded. Descriptive statistical analysis was performed. RESULTS: All specimens survived the biomechanical test protocol. Displacement during cyclic loading was 2.8 ± 0.9 mm, yield load was 475.2 ± 36 N, ultimate load at failure was 671.4 ± 98 N, stiffness was 127.5 ± 15 N/mm. The most common failure mode was suture pulling through the soft tissue graft. CONCLUSIONS: This ACL reconstruction method combines the high ultimate load to failure and low graft slippage of extra-cortical button suspensory fixation with the high stiffness of aperture fixation. Biomechanical test findings were comparable or better to previous reports for displacement during submaximal loading, ultimate failure load, and construct stiffness. Based on current understanding of soft tissue graft ACL reconstruction biomechanics, this fixation method should enhance graft-bone socket integration during healing, facilitate long-term graft survival, and improve patient outcomes. Clinical studies are needed to confirm in vivo efficacy.

Progressive resistance, whole body long-axis rotational training improves kicking motion motor performance.

OBJECTIVES: To evaluate lower extremity muscle activation, peak resultant ground reaction force (GRF) production and quickness during performance of a kicking motion following progressive resistance, whole body long-axis rotational training. DESIGN: Randomized, controlled study. SETTING: Kinesiological research laboratory. PARTICIPANTS: Thirty-six healthy subjects were assigned to a training (Group 1) or to a control (Group 2) group. MAIN OUTCOME MEASURES: Time-synchronized EMG (1000 Hz), peak resultant GRF (1000 Hz) and two-dimensional kinematic (60 Hz) data were collected as subjects responded to an audio cue by kicking a cone. Group mean change differences (MCD) were compared using independent sample t-tests. Fisher's exact tests were used to determine group differences in the proportion of subjects that displayed earlier activation responses post-training. RESULTS: Group 1 MCD revealed earlier gluteus maximus, gluteus medius, rectus femoris, medial hamstrings, and biceps femoris activation timing than Group 2 (P ≤ 0.006) and more Group 1 subjects displayed earlier activation of these muscles post-training (P ≤ 0.041). Group 1 MCD also revealed earlier peak resultant GRF timing and improved "kick quickness" than Group 2 (P ≤ 0.014) and more Group 1 subjects displayed earlier response timing for these variables post-training (P = 0.035). CONCLUSION: Progressive resistance, whole body long-axis rotational training may improve performance during sports movements that require quick, integrated trunk-lower extremity function.

Outside-in continuous suturing is superior to interrupted suturing for repairing peripheral meniscus lesions: an in vitro biomechanical study using a porcine model.

PURPOSE: This in vitro biomechanical study using a porcine model compared peripheral longitudinal vertical meniscus lesion (PLVML) outside-in suture repair fixation strength using either interrupted or continuous "N" configuration No. 2-0 braided polyester sutures. METHODS: Porcine lateral menisci were randomly assigned to group 1 (continuous) or group 2 (interrupted). Standardized PLVMLs were created in each specimen. Repaired specimens were placed in a specially designed clamp and loaded into a servohydraulic device. Specimens underwent preconditioning for 10 cycles (0.1 Hz, 5 to 20 N) and 500 submaximal loading cycles (0.5 Hz, 5 to 20 N), before load-to-failure testing (12.5 mm/s). A 30-second pause after preconditioning and after 10, 100, and 500 submaximal loading cycles enabled standardized digital photographs to be taken for gapping measurement determination. The failure mode was documented. RESULTS: Displacement and gapping during preconditioning and submaximal loading cycles did not differ between groups. Group 1 withstood a greater failure load (mean, 118.3 N; 95% confidence interval [CI], 97.2 to 139.4 N) than group 2 (mean, 63.7 N; 95% CI, 51.2 to 76.2 N) (P < .0001) and displacement during load-to-failure testing (mean, 5.3 mm; 95% CI, 4.2 to 6.5 mm) than group 2 (mean, 3.2 mm; 95% CI, 2.1 to 4.3 mm) (P = .005). Group 1 failed by suture breakage or suture pulling through tissue, whereas group 2 primarily failed by knot slippage (P < .0001). CONCLUSIONS: Group displacement and gapping differences were not observed after 500 submaximal loading cycles. PLVMLs repaired with a continuous N configuration, however, withstood greater load at failure and greater displacement before failure than repairs that used interrupted sutures. CLINICAL RELEVANCE: Continuous suture in an N configuration may improve PLVML repair fixation strength.

Repair of peripheral vertical meniscus lesions in porcine menisci: in vitro biomechanical testing of 3 different meniscus repair devices.

BACKGROUND: All-inside meniscus repair eliminates the need for an extra incision and decreases neurovascular injury risk. Biomechanical testing can help delineate the efficacy of all-inside device use. HYPOTHESIS: There would be no group differences between 4 peripheral meniscus repair techniques and 3 different devices tested. STUDY DESIGN: Controlled laboratory study. METHODS: Equivalent-sized menisci with attached tibiae were randomly assigned to 1 of 4 test groups (8 specimens each), as follows: group 1, Fast-Fix using No. 0 braided polyester suture; group 2, inside-out repair using 2-0 braided polyester suture; group 3, Sequent using No. 0 ultra-high molecular weight polyethylene (UHMWPE) suture in a continuous "N" configuration; and group 4, Sequent using No. 0 UHMWPE suture in an interrupted configuration. After placement in a clamp, specimens underwent preconditioning from 5 to 20 N for 10 cycles (0.1 Hz), 500 submaximal loading cycles from 5 to 20 N (0.5 Hz), and load-to-failure testing at 12.5 mm/s. A 30-second pause after 10 preconditioning cycles and after 10, 100, and 500 submaximal loading cycles enabled digital photographs to be taken for gapping measurements. Failure mode was recorded. RESULTS: Specimens in group 3 withstood greater failure loads than did those in groups 1 and 4 (P ≤ .027), and group 3 specimens were stiffer than those in groups 2 and 4 (P ≤ .048). Displacement during submaximal loading and load-to-failure testing did not differ between groups. Groups 1, 3, and 4 each gapped less than group 2 during submaximal cyclic loading (P ≤ .05). Groups 1 and 2 failed primarily by suture breakage (P < .0001), while groups 3 and 4 failed primarily by the suture pulling free from an implant (P < .0001). CONCLUSION: Sequent using No. 0 UHMWPE suture in a continuous "N" configuration displayed superior load at failure compared with repairs using Fast-Fix with No. 0 braided polyester suture and displayed greater stiffness and less gapping than inside-out repair using 2-0 braided polyester suture. The suture pulling free from an implant was the primary failure mode for Sequent using No. 0 UHMWPE suture regardless of whether a continuous "N" or an interrupted configuration was used. Study groups that used No. 0 UHMWPE sutures (groups 3 and 4) had more specimens fail by the suture pulling free from an implant. Compared with the weaker braided polyester suture in the inside-out and Fast-Fix groups, the No. 0 UHMWPE suture used in the Sequent groups likely influenced study results, as this suture has stronger material properties. However, the continuous "N" configuration likely also improved the performance of the Sequent with No. 0 UHMWPE suture, as failure load was significantly less with an interrupted configuration. CLINICAL RELEVANCE: All-inside meniscus repair with continuous suture function may translate into improved patient outcomes.

Viscosupplementation with hyaluronic acid in the treatment for cartilage lesions: a review of current evidence and future directions.

Diseases involving the articular cartilage are one of the leading causes of physical impairment among the adult population. While surgical technique and advancement have allowed us effective means at treating these diseases, this is not without significant risk and morbidity. With a very solid safety profile, viscosupplementation with hyaluronic acid (HA) derivatives has become an excellent modality for treating diseased articular cartilage. Recent literature supports the use of HA not only in the management of the pain associated with osteoarthritis but also as a disease-modifying agent as well. Further studies have started to define exciting new roles for viscosupplementation in the treatment for acute injuries to the joint microenvironment.